1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	H	G	S	T	A	H	E	V	L	A	V	V	F	Q	V	R	G	V	G	M	S	R	G	A	A	K	P	Q	L	N	V	L	L	W	Q	R	A	K	E	P	Q	R	G	A	W	S	L	P	G	G	R	L	R	N	D	E	D	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	S	S	V	R	R	Q	L	A	E	K	V	D	L	R	E	L	A	H	L	E	Q	L	A	V	F	S	D	P	H	R	L	P	G	I	R	M	I	A	S	T	Y	L	G	V	V	P	S	P	A	T	P	E	L	P	A	D	T	R	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	P	V	S	S	L	P	P	M	A	F	D	H	G	P	M	V	T	H	A	R	T	R	L	I	A	K	M	S	Y	T	N	I	G	F	A	L	A	P	K	E	F	A	L	S	T	L	R	D	I	Y	G	A	A	L	G	Y	Q	V	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.
Sequence		A	T	N	L	Q	R	V	L	A	R	R	R	V	I	T	Q	T	G	T	I	A	Q	S	G	R	S	G	G	R	P	A	A	L	Y	R	F	T	D	S	Q	L	R	V	T	D	E	F	A	A	L	R	P	P	G	Q	L
Secondary structure
SS confidence
Disorder											?	?									?	?	?	?	?	?	?	?	?													?	?			?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 29%) Beta strand ( 25%)

Rank Aligned region

PDB 2fb1 chain A Region: 2 - 227 Aligned: 214 Modelled: 226 Confidence: 100.0% Identity: 30% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of protein bt0354 from bacteroides thetaiotaomicron Phyre2 PDB 3gz6 chain A Region: 10 - 223 Aligned: 201 Modelled: 214 Confidence: 100.0% Identity: 29% PDB header:dna binding protein/dna Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of shewanella oneidensis nrtr complexed with a 27mer2 dna Phyre2 PDB 2fml chain B Region: 10 - 218 Aligned: 191 Modelled: 209 Confidence: 100.0% Identity: 28% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt/nudix family protein from enterococcus2 faecalis Phyre2 PDB 2fml chain A domain 2 Region: 10 - 151 Aligned: 135 Modelled: 142 Confidence: 100.0% Identity: 32% Fold: Nudix Superfamily: Nudix Family: BT0354 N-terminal domain-like Phyre2 PDB 2fb1 chain A domain 2 Region: 2 - 151 Aligned: 140 Modelled: 150 Confidence: 100.0% Identity: 27% Fold: Nudix Superfamily: Nudix Family: BT0354 N-terminal domain-like Phyre2 PDB 1q33 chain A Region: 8 - 154 Aligned: 144 Modelled: 147 Confidence: 100.0% Identity: 13% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3gz8 chain C Region: 5 - 145 Aligned: 131 Modelled: 141 Confidence: 100.0% Identity: 33% PDB header:dna binding protein Chain: C: PDB Molecule:mutt/nudix family protein; PDBTitle: cocrystal structure of nudix domain of shewanella oneidensis nrtr2 complexed with adp ribose Phyre2 PDB 3i9x chain A Region: 10 - 151 Aligned: 136 Modelled: 142 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of a mutt/nudix family protein from listeria innocua Phyre2 PDB 2qjo chain B Region: 5 - 144 Aligned: 127 Modelled: 127 Confidence: 100.0% Identity: 27% PDB header:transferase, hydrolase Chain: B: PDB Molecule:bifunctional nmn adenylyltransferase/nudix hydrolase; PDBTitle: crystal structure of a bifunctional nmn adenylyltransferase/adp ribose2 pyrophosphatase (nadm) complexed with adprp and nad from3 synechocystis sp. Phyre2 PDB 2r5w chain A Region: 5 - 143 Aligned: 126 Modelled: 126 Confidence: 100.0% Identity: 28% PDB header:hydrolase, transferase Chain: A: PDB Molecule:nicotinamide-nucleotide adenylyltransferase; PDBTitle: crystal structure of a bifunctional nmn2 adenylyltransferase/adp ribose pyrophosphatase from3 francisella tularensis Phyre2 PDB 4zbp chain C Region: 18 - 191 Aligned: 159 Modelled: 173 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase 7; PDBTitle: crystal structure of the ampcpr-bound atnudt7 Phyre2 PDB 2yyh chain C Region: 10 - 142 Aligned: 122 Modelled: 133 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:8-oxo-dgtpase domain; PDBTitle: crystal structure of nudix family protein from aquifex aeolicus Phyre2 PDB 2fb1 chain A domain 1 Region: 152 - 227 Aligned: 74 Modelled: 76 Confidence: 99.9% Identity: 36% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Nudix-associated domain Phyre2 PDB 3h95 chain A Region: 19 - 163 Aligned: 140 Modelled: 145 Confidence: 99.9% Identity: 12% PDB header:gene regulation Chain: A: PDB Molecule:nucleoside diphosphate-linked moiety x motif 6; PDBTitle: crystal structure of the nudix domain of nudt6 Phyre2 PDB 5bon chain C Region: 9 - 130 Aligned: 111 Modelled: 122 Confidence: 99.9% Identity: 27% PDB header:hydrolase Chain: C: PDB Molecule:probable 8-oxo-dgtp diphosphatase nudt15; PDBTitle: crystal structure of human nudt15 (mth2) Phyre2 PDB 3cng chain C Region: 18 - 157 Aligned: 134 Modelled: 140 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea Phyre2 PDB 2gb5 chain B Region: 18 - 147 Aligned: 124 Modelled: 130 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:nadh pyrophosphatase; PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution Phyre2 PDB 3exq chain A Region: 17 - 139 Aligned: 122 Modelled: 123 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:nudix family hydrolase; PDBTitle: crystal structure of a nudix family hydrolase from2 lactobacillus brevis Phyre2 PDB 3fcm chain A Region: 18 - 146 Aligned: 126 Modelled: 129 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family; PDBTitle: crystal structure of a nudix hydrolase from clostridium perfringens Phyre2 PDB 1iry chain A Region: 6 - 142 Aligned: 125 Modelled: 126 Confidence: 99.9% Identity: 18% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 1 c2fb1A_ 2 c3gz6A_ 3 c2fmlB_ 4 d2fmla2 5 d2fb1a2 6 d1q33a_ 7 c3gz8C_ 8 c3i9xA_ 9 c2qjoB_ 10 c2r5wA_ 11 c4zbpC_ 12 c2yyhC_ 13 d2fb1a1 14 c3h95A_ 15 c5bonC_ 16 c3cngC_ 17 c2gb5B_ 18 c3exqA_ 19 c3fcmA_ 20 d1irya_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136