1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	V	L	N	R	T	D	T	L	V	D	E	L	T	A	D	I	T	N	T	P	L	G	Y	G	G	V	D	G	D	E	R	W	A	A	E	I	R	R	L	A	H	L	R	G	A	T	V	L	A	H	N	Y	Q	L	P	A	I	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?												?			?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	V	A	D	H	V	G	D	S	L	A	L	S	R	V	A	A	E	A	P	E	D	T	I	V	F	C	G	V	H	F	M	A	E	T	A	K	I	L	S	P	H	K	T	V	L	I	P	D	Q	R	A	G	C	S	L	A	D	S	I
Secondary structure
SS confidence
Disorder																																								?		?		?												?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	P	D	E	L	R	A	W	K	D	E	H	P	G	A	V	V	V	S	Y	V	N	T	T	A	A	V	K	A	L	T	D	I	C	C	T	S	S	N	A	V	D	V	V	A	S	I	D	P	D	R	E	V	L	F	C	P	D	Q	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	G	A	H	V	R	R	V	T	G	R	K	N	L	H	V	W	A	G	E	C	H	V	H	A	G	I	N	G	D	E	L	A	D	Q	A	R	A	H	P	D	A	E	L	F	V	H	P	E	C	G	C	A	T	S	A	L	Y	L	A
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	E	G	A	F	P	A	E	R	V	K	I	L	S	T	G	G	M	L	E	A	A	H	T	T	R	A	R	Q	V	L	V	A	T	E	V	G	M	L	H	Q	L	R	R	A	A	P	E	V	D	F	R	A	V	N	D	R	A	S	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.
Sequence		K	Y	M	K	M	I	T	P	A	A	L	L	R	C	L	V	E	G	A	D	E	V	H	V	D	P	G	I	A	A	S	G	R	R	S	V	Q	R	M	I	E	I	G	H	P	G	G	G	E
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 46%) Beta strand ( 16%)

Rank Aligned region

PDB 4p3x chain A Region: 31 - 343 Aligned: 299 Modelled: 313 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:quinolinate synthase a; PDBTitle: structure of the fe4s4 quinolinate synthase nada from thermotoga2 maritima Phyre2 PDB 2qs0 chain A Region: 28 - 343 Aligned: 293 Modelled: 316 Confidence: 100.0% Identity: 42% PDB header:biosynthetic protein Chain: A: PDB Molecule:quinolinate synthetase a; PDBTitle: quinolinate synthase from pyrococcus furiosus Phyre2 PDB 1wzu chain A domain 1 Region: 33 - 342 Aligned: 270 Modelled: 310 Confidence: 100.0% Identity: 43% Fold: NadA-like Superfamily: NadA-like Family: NadA-like Phyre2 PDB 6mgd chain A Region: 168 - 267 Aligned: 77 Modelled: 89 Confidence: 84.4% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:capsular polysaccharide export system protein kpsc; PDBTitle: thermosulfurimonas dismutans kpsc, beta kdo 2,4 transferase Phyre2 PDB 5ldr chain A Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 71.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:beta-d-galactosidase; PDBTitle: crystal structure of a cold-adapted dimeric beta-d-galactosidase from2 paracoccus sp. 32d strain in complex with galactose Phyre2 PDB 6j7a chain B Region: 4 - 56 Aligned: 46 Modelled: 53 Confidence: 66.8% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:heme oxygenase 1,nadph--cytochrome p450 reductase; PDBTitle: fusion protein of heme oxygenase-1 and nadph cytochrome p450 reductase2 (17aa) Phyre2 PDB 1xhj chain A Region: 112 - 144 Aligned: 33 Modelled: 33 Confidence: 62.4% Identity: 24% Fold: Alpha-lytic protease prodomain-like Superfamily: Fe-S cluster assembly (FSCA) domain-like Family: NifU C-terminal domain-like Phyre2 PDB 1zq1 chain B Region: 57 - 100 Aligned: 44 Modelled: 44 Confidence: 59.6% Identity: 27% PDB header:lyase Chain: B: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit d; PDBTitle: structure of gatde trna-dependent amidotransferase from2 pyrococcus abyssi Phyre2 PDB 1j97 chain A Region: 99 - 168 Aligned: 55 Modelled: 56 Confidence: 58.2% Identity: 18% Fold: HAD-like Superfamily: HAD-like Family: Phosphoserine phosphatase Phyre2 PDB 3p04 chain B Region: 35 - 87 Aligned: 53 Modelled: 53 Confidence: 56.6% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 Phyre2 PDB 6b6l chain B Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 54.5% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:glycosyl hydrolase family 2, sugar binding domain protein; PDBTitle: the crystal structure of glycosyl hydrolase family 2 (gh2) member from2 bacteroides cellulosilyticus dsm 14838 Phyre2 PDB 5t9g chain D Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 54.1% Identity: 24% PDB header:hydrolase Chain: D: PDB Molecule:glycoside hydrolase; PDBTitle: crystal structure of bugh2cwt in complex with galactoisofagomine Phyre2 PDB 1hru chain A Region: 92 - 179 Aligned: 88 Modelled: 88 Confidence: 53.9% Identity: 14% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: YrdC-like Phyre2 PDB 3zih chain B Region: 35 - 87 Aligned: 53 Modelled: 53 Confidence: 52.8% Identity: 19% PDB header:cell cycle Chain: B: PDB Molecule:cell division protein sepf; PDBTitle: bacillus subtilis sepf, c-terminal domain Phyre2 PDB 6dxu chain B Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 51.9% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:glycosyl hydrolase family 2, tim barrel domain protein; PDBTitle: crystal structure of parabacteroides merdae beta-glucuronidase (gus) Phyre2 PDB 3fn9 chain B Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 49.6% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:putative beta-galactosidase; PDBTitle: crystal structure of putative beta-galactosidase from bacteroides2 fragilis Phyre2 PDB 6d8k chain D Region: 22 - 67 Aligned: 46 Modelled: 46 Confidence: 49.5% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:glycosyl hydrolase family 2, sugar binding domain protein; PDBTitle: bacteroides multiple species beta-glucuronidase Phyre2 PDB 5nkz chain C Region: 213 - 295 Aligned: 61 Modelled: 61 Confidence: 48.7% Identity: 16% PDB header:transferase Chain: C: PDB Molecule:peroxin 22; PDBTitle: crystal structure of h. polymorpha ubiquitin conjugating enzyme pex4p2 in complex with soluble domain of pex22p Phyre2 PDB 3cmg chain A Region: 26 - 67 Aligned: 42 Modelled: 42 Confidence: 48.6% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:putative beta-galactosidase; PDBTitle: crystal structure of putative beta-galactosidase from bacteroides2 fragilis Phyre2 PDB 3p04 chain A Region: 35 - 87 Aligned: 53 Modelled: 53 Confidence: 48.6% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 Phyre2 1 c4p3xA_ 2 c2qs0A_ 3 d1wzua1 4 c6mgdA_ 5 c5ldrA_ 6 c6j7aB_ 7 d1xhja_ 8 c1zq1B_ 9 d1j97a_ 10 c3p04B_ 11 c6b6lB_ 12 c5t9gD_ 13 d1hrua_ 14 c3zihB_ 15 c6dxuB_ 16 c3fn9B_ 17 c6d8kD_ 18 c5nkzC_ 19 c3cmgA_ 20 c3p04A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99