1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	T	R	I	D	L	R	G	A	E	L	T	A	A	E	L	R	A	A	L	P	R	G	G	A	D	V	E	A	V	L	P	T	V	R	P	I	V	A	A	V	A	E	R	G	A	E	A	A	L	D	F	G	A	S	F	D	G	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?														?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	P	H	A	I	R	V	P	D	A	A	L	D	A	A	L	A	G	L	D	C	D	V	C	E	A	L	Q	V	M	V	E	R	T	R	A	V	H	S	G	Q	R	R	T	D	V	T	T	T	L	G	P	G	A	T	V	T	E	R	W
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	P	V	E	R	V	G	L	Y	V	P	G	G	N	A	V	Y	P	S	S	V	V	M	N	V	V	P	A	Q	A	A	G	V	D	S	L	V	V	A	S	P	P	Q	A	Q	W	D	G	M	P	H	P	T	I	L	A	A	A	R	L
Secondary structure
SS confidence
Disorder																																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	G	V	D	E	V	W	A	V	G	G	A	Q	A	V	A	L	L	A	Y	G	G	T	D	T	D	G	A	A	L	T	P	V	D	M	I	T	G	P	G	N	I	Y	V	T	A	A	K	R	L	C	R	S	R	V	G	I	D	A	E
Secondary structure
SS confidence
Disorder																										?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	P	T	E	I	A	I	L	A	D	H	T	A	D	P	V	H	V	A	A	D	L	I	S	Q	A	E	H	D	E	L	A	A	S	V	L	V	T	P	S	E	D	L	A	D	A	T	D	A	E	L	A	G	Q	L	Q	T	T	V
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	R	E	R	V	T	A	A	L	T	G	R	Q	S	A	I	V	L	V	D	D	V	D	A	A	V	L	V	V	N	A	Y	A	A	E	H	L	E	I	Q	T	A	D	A	P	Q	V	A	S	R	I	R	S	A	G	A	I	F	V	G
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	W	S	P	V	S	L	G	D	Y	C	A	G	S	N	H	V	L	P	T	A	G	C	A	R	H	S	S	G	L	S	V	Q	T	F	L	R	G	I	H	V	V	E	Y	T	E	A	A	L	K	D	V	S	G	H	V	I	T	L	A
Secondary structure
SS confidence
Disorder																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.
Sequence		T	A	E	D	L	P	A	H	G	E	A	V	R	R	R	F	E	R
Secondary structure
SS confidence
Disorder																		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 51%) Beta strand ( 14%)

Rank Aligned region

PDB 6an0 chain A Region: 13 - 438 Aligned: 417 Modelled: 426 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:histidinol dehydrogenase; PDBTitle: crystal structure of histidinol dehydrogenase from elizabethkingia2 anophelis Phyre2 PDB 1k75 chain A Region: 7 - 438 Aligned: 419 Modelled: 432 Confidence: 100.0% Identity: 38% Fold: ALDH-like Superfamily: ALDH-like Family: L-histidinol dehydrogenase HisD Phyre2 PDB 5vld chain C Region: 7 - 438 Aligned: 421 Modelled: 432 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: C: PDB Molecule:histidinol dehydrogenase, chloroplastic; PDBTitle: crystal structure of medicago truncatula l-histidinol dehydrogenase in2 complex with l-histidine and nad+ Phyre2 PDB 4g07 chain A Region: 2 - 438 Aligned: 417 Modelled: 437 Confidence: 100.0% Identity: 43% PDB header:oxidoreductase Chain: A: PDB Molecule:histidinol dehydrogenase; PDBTitle: the crystal structure of the c366s mutant of hdh from brucella suis Phyre2 PDB 4gic chain B Region: 2 - 405 Aligned: 375 Modelled: 388 Confidence: 100.0% Identity: 41% PDB header:oxidoreductase Chain: B: PDB Molecule:histidinol dehydrogenase; PDBTitle: crystal structure of a putative histidinol dehydrogenase (target psi-2 014034) from methylococcus capsulatus Phyre2 PDB 4go4 chain E Region: 14 - 401 Aligned: 347 Modelled: 370 Confidence: 98.7% Identity: 16% PDB header:oxidoreductase Chain: E: PDB Molecule:putative gamma-hydroxymuconic semialdehyde dehydrogenase; PDBTitle: crystal structure of pnpe in complex with nicotinamide adenine2 dinucleotide Phyre2 PDB 2w8q chain A Region: 14 - 404 Aligned: 348 Modelled: 369 Confidence: 98.6% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:succinate-semialdehyde dehydrogenase, PDBTitle: the crystal structure of human ssadh in complex with ssa. Phyre2 PDB 1ky8 chain A Region: 81 - 402 Aligned: 299 Modelled: 321 Confidence: 98.6% Identity: 17% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 4jbe chain A Region: 14 - 402 Aligned: 356 Modelled: 372 Confidence: 98.5% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:gamma-glutamyl phosphate reductase; PDBTitle: 1.95 angstrom crystal structure of gamma-glutamyl phosphate reductase2 from saccharomonospora viridis. Phyre2 PDB 5mz5 chain A Region: 14 - 403 Aligned: 355 Modelled: 383 Confidence: 98.5% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:aldh21); PDBTitle: crystal structure of aldehyde dehydrogenase 21 (aldh21) from2 physcomitrella patens in its apoform Phyre2 PDB 1bxs chain A Region: 9 - 402 Aligned: 343 Modelled: 362 Confidence: 98.5% Identity: 17% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 3vz0 chain B Region: 8 - 401 Aligned: 340 Modelled: 359 Confidence: 98.5% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:putative nad-dependent aldehyde dehydrogenase; PDBTitle: structural insights into cofactor and substrate selection by gox0499 Phyre2 PDB 3k9d chain D Region: 14 - 401 Aligned: 352 Modelled: 369 Confidence: 98.5% Identity: 15% PDB header:oxidoreductase Chain: D: PDB Molecule:aldehyde dehydrogenase; PDBTitle: crystal structure of probable aldehyde dehydrogenase from listeria2 monocytogenes egd-e Phyre2 PDB 3lns chain D Region: 14 - 402 Aligned: 353 Modelled: 387 Confidence: 98.4% Identity: 18% PDB header:oxidoreductase Chain: D: PDB Molecule:benzaldehyde dehydrogenase; PDBTitle: benzaldehyde dehydrogenase, a class 3 aldehyde dehydrogenase, with2 bound nadp+ and benzoate adduct Phyre2 PDB 3efv chain C Region: 14 - 403 Aligned: 346 Modelled: 381 Confidence: 98.4% Identity: 18% PDB header:oxidoreductase Chain: C: PDB Molecule:putative succinate-semialdehyde dehydrogenase; PDBTitle: crystal structure of a putative succinate-semialdehyde dehydrogenase2 from salmonella typhimurium lt2 with bound nad Phyre2 PDB 4h7n chain A Region: 14 - 402 Aligned: 349 Modelled: 369 Confidence: 98.4% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:aldehyde dehydrogenase; PDBTitle: the structure of putative aldehyde dehydrogenase puta from anabaena2 variabilis. Phyre2 PDB 1euh chain A Region: 14 - 403 Aligned: 356 Modelled: 390 Confidence: 98.4% Identity: 14% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 5j6b chain B Region: 14 - 402 Aligned: 349 Modelled: 381 Confidence: 98.3% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:aldehyde dehydrogenase; PDBTitle: crystal structure of aldehyde dehydrogenase from burkholderia2 thailandensis in covelent complex with nadph Phyre2 PDB 1ag8 chain A Region: 9 - 402 Aligned: 336 Modelled: 362 Confidence: 98.3% Identity: 16% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 5vbf chain H Region: 14 - 405 Aligned: 351 Modelled: 373 Confidence: 98.2% Identity: 17% PDB header:oxidoreductase Chain: H: PDB Molecule:nad-dependent succinate-semialdehyde dehydrogenase; PDBTitle: crystal structure of succinate semialdehyde dehydrogenase from2 burkholderia vietnamiensis Phyre2 1 c6an0A_ 2 d1k75a_ 3 c5vldC_ 4 c4g07A_ 5 c4gicB_ 6 c4go4E_ 7 c2w8qA_ 8 d1ky8a_ 9 c4jbeA_ 10 c5mz5A_ 11 d1bxsa_ 12 c3vz0B_ 13 c3k9dD_ 14 c3lnsD_ 15 c3efvC_ 16 c4h7nA_ 17 d1euha_ 18 c5j6bB_ 19 d1ag8a_ 20 c5vbfH_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144