1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	T	Q	T	A	K	A	S	R	R	A	R	I	E	R	R	T	R	E	S	D	I	V	I	E	L	D	L	D	G	T	G	Q	V	A	V	D	T	G	V	P	F	Y	D	H	M	L	T	A	L	G	S	H	A	S	F	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?										?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	V	R	A	T	G	D	V	E	I	E	A	H	H	T	I	E	D	T	A	I	A	L	G	T	A	L	G	Q	A	L	G	D	K	R	G	I	R	R	F	G	D	A	F	I	P	M	D	E	T	L	A	H	A	A	V	D	L	S	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	P	Y	C	V	H	T	G	E	P	D	H	L	Q	H	T	T	I	A	G	S	S	V	P	Y	H	T	V	I	N	R	H	V	F	E	S	L	A	A	N	A	R	I	A	L	H	V	R	V	L	Y	G	R	D	P	H	H	I	T	E
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence		A	Q	Y	K	A	V	A	R	A	L	R	Q	A	V	E	P	D	P	R	V	S	G	V	P	S	T	K	G	A	L
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 32%) Beta strand ( 32%)

Rank Aligned region

PDB 6fwh chain H Region: 11 - 210 Aligned: 193 Modelled: 200 Confidence: 100.0% Identity: 47% PDB header:lyase Chain: H: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: acanthamoeba igpd in complex with r-c348 to 1.7a resolution Phyre2 PDB 6ezm chain L Region: 11 - 210 Aligned: 192 Modelled: 200 Confidence: 100.0% Identity: 44% PDB header:lyase Chain: L: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae Phyre2 PDB 4lom chain A Region: 10 - 200 Aligned: 191 Modelled: 191 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: A: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: crystal structure of mycobacterium tuberculosis hisb in complex with2 its substrate Phyre2 PDB 2f1d chain P Region: 11 - 199 Aligned: 182 Modelled: 189 Confidence: 100.0% Identity: 51% PDB header:lyase Chain: P: PDB Molecule:imidazoleglycerol-phosphate dehydratase 1; PDBTitle: x-ray structure of imidazoleglycerol-phosphate dehydratase Phyre2 PDB 5dnl chain A Region: 15 - 210 Aligned: 176 Modelled: 196 Confidence: 100.0% Identity: 38% PDB header:lyase Chain: A: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: crystal structure of igpd from pyrococcus furiosus in complex with2 (s)-c348 Phyre2 PDB 1rhy chain B Region: 9 - 197 Aligned: 175 Modelled: 182 Confidence: 100.0% Identity: 39% PDB header:lyase Chain: B: PDB Molecule:imidazole glycerol phosphate dehydratase; PDBTitle: crystal structure of imidazole glycerol phosphate dehydratase Phyre2 PDB 2ae8 chain C Region: 17 - 197 Aligned: 169 Modelled: 181 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: C: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: crystal structure of imidazoleglycerol-phosphate dehydratase from2 staphylococcus aureus subsp. aureus n315 Phyre2 PDB 2f1d chain A domain 2 Region: 96 - 199 Aligned: 97 Modelled: 104 Confidence: 100.0% Identity: 51% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 1rhy chain A domain 2 Region: 96 - 196 Aligned: 94 Modelled: 101 Confidence: 100.0% Identity: 35% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 2ae8 chain A domain 2 Region: 97 - 197 Aligned: 94 Modelled: 101 Confidence: 100.0% Identity: 36% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 2f1d chain A domain 1 Region: 11 - 95 Aligned: 85 Modelled: 85 Confidence: 100.0% Identity: 51% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 1rhy chain A domain 1 Region: 9 - 95 Aligned: 81 Modelled: 87 Confidence: 100.0% Identity: 43% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 2ae8 chain A domain 1 Region: 17 - 95 Aligned: 74 Modelled: 79 Confidence: 100.0% Identity: 30% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 2ja9 chain A domain 2 Region: 48 - 90 Aligned: 41 Modelled: 43 Confidence: 78.0% Identity: 15% Fold: Eukaryotic type KH-domain (KH-domain type I) Superfamily: Eukaryotic type KH-domain (KH-domain type I) Family: Eukaryotic type KH-domain (KH-domain type I) Phyre2 PDB 2ja9 chain A Region: 47 - 90 Aligned: 42 Modelled: 44 Confidence: 65.4% Identity: 14% PDB header:rna-binding protein Chain: A: PDB Molecule:exosome complex exonuclease rrp40; PDBTitle: structure of the n-terminal deletion of yeast exosome2 component rrp40 Phyre2 PDB 4ifd chain G Region: 47 - 90 Aligned: 42 Modelled: 44 Confidence: 55.0% Identity: 14% PDB header:hydrolase/rna Chain: G: PDB Molecule:exosome complex component rrp40; PDBTitle: crystal structure of an 11-subunit eukaryotic exosome complex bound to2 rna Phyre2 PDB 2nn6 chain G domain 3 Region: 48 - 90 Aligned: 41 Modelled: 41 Confidence: 42.0% Identity: 15% Fold: Eukaryotic type KH-domain (KH-domain type I) Superfamily: Eukaryotic type KH-domain (KH-domain type I) Family: Eukaryotic type KH-domain (KH-domain type I) Phyre2 PDB 3j6v chain E Region: 78 - 186 Aligned: 90 Modelled: 99 Confidence: 36.0% Identity: 18% PDB header:ribosome Chain: E: PDB Molecule:28s ribosomal protein s5, mitochondrial; PDBTitle: cryo-em structure of the small subunit of the mammalian mitochondrial2 ribosome Phyre2 PDB 2k8h chain A Region: 3 - 81 Aligned: 78 Modelled: 79 Confidence: 34.8% Identity: 6% PDB header:signaling protein Chain: A: PDB Molecule:small ubiquitin protein; PDBTitle: solution structure of sumo from trypanosoma brucei Phyre2 PDB 4ywj chain B Region: 36 - 94 Aligned: 52 Modelled: 59 Confidence: 32.1% Identity: 31% PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxy-tetrahydrodipicolinate reductase; PDBTitle: crystal structure of 4-hydroxy-tetrahydrodipicolinate reductase (htpa2 reductase) from pseudomonas aeruginosa Phyre2 1 c6fwhH_ 2 c6ezmL_ 3 c4lomA_ 4 c2f1dP_ 5 c5dnlA_ 6 c1rhyB_ 7 c2ae8C_ 8 d2f1da2 9 d1rhya2 10 d2ae8a2 11 d2f1da1 12 d1rhya1 13 d2ae8a1 14 d2ja9a2 15 c2ja9A_ 16 c4ifdG_ 17 d2nn6g3 18 c3j6vE_ 19 c2k8hA_ 20 c4ywjB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99