1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	L	D	S	L	V	A	P	L	V	E	Q	A	S	A	I	L	D	A	A	T	A	L	F	L	V	G	H	R	A	D	S	A	V	R	K	K	G	N	D	F	A	T	E	V	D	L	A	I	E	R	Q	V	V	A	A	L	V	A
Secondary structure
SS confidence
Disorder		?	?	?																												?	?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	T	G	I	E	V	H	G	E	E	F	G	G	P	A	V	D	S	R	W	V	W	V	L	D	P	I	D	G	T	I	N	Y	A	A	G	S	P	L	A	A	I	L	L	G	L	L	H	D	G	V	P	V	A	G	L	T	W	M	P
Secondary structure
SS confidence
Disorder													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	T	D	P	R	Y	T	A	V	A	G	G	P	L	I	K	N	G	V	P	Q	P	P	L	A	D	A	E	L	A	N	V	L	V	G	V	G	T	F	S	A	D	S	R	G	Q	F	P	G	R	Y	R	L	A	V	L	E	K	L	S
Secondary structure
SS confidence
Disorder																							?	?	?	?	?		?											?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	V	S	S	R	L	R	M	H	G	S	T	G	I	D	L	V	F	V	A	D	G	I	L	G	G	A	I	S	F	G	G	H	V	W	D	H	A	A	G	V	A	L	V	R	A	A	G	G	V	V	T	D	L	A	G	Q	P	W	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270
Sequence		P	A	S	R	S	A	L	A	G	P	P	R	V	H	A	Q	I	L	E	I	L	G	S	I	G	E	P	E	D	Y
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 38%) Beta strand ( 24%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3ryd chain A Region: 7 - 270 Aligned: 254 Modelled: 264 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal strucutre of ca bound impase family protein from2 staphylococcus aureus Phyre2 PDB 2hhm chain A Region: 8 - 269 Aligned: 261 Modelled: 262 Confidence: 100.0% Identity: 21% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2qfl chain A Region: 7 - 263 Aligned: 254 Modelled: 257 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of suhb: inositol monophosphatase and extragenic2 suppressor from e. coli Phyre2 PDB 3t0j chain B Region: 9 - 268 Aligned: 250 Modelled: 260 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal structure of inositol monophosphatase - ii from staphylococcus2 aureus mssa476 Phyre2 PDB 3qmf chain A Region: 7 - 270 Aligned: 248 Modelled: 264 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal strucuture of an inositol monophosphatase family protein2 (sas2203) from staphylococcus aureus mssa476 Phyre2 PDB 2p3n chain B Region: 10 - 264 Aligned: 244 Modelled: 255 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: thermotoga maritima impase tm1415 Phyre2 PDB 3luz chain A Region: 8 - 263 Aligned: 236 Modelled: 256 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:extragenic suppressor protein suhb; PDBTitle: crystal structure of extragenic suppressor protein suhb from2 bartonella henselae, via combined iodide sad molecular replacement Phyre2 PDB 5zon chain A Region: 8 - 262 Aligned: 248 Modelled: 255 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:histidinol-phosphatase; PDBTitle: histidinol phosphate phosphatase from mycobacterium tuberculosis Phyre2 PDB 2czh chain B Region: 8 - 263 Aligned: 242 Modelled: 256 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: crystal structure of human myo-inositol monophosphatase 22 (impa2) with phosphate ion (orthorhombic form) Phyre2 PDB 4n81 chain A Region: 7 - 262 Aligned: 245 Modelled: 256 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase; PDBTitle: another flexible region at the active site of an inositol2 monophosphatase from zymomonas mobilis Phyre2 PDB 5zhh chain B Region: 7 - 267 Aligned: 236 Modelled: 261 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of inositol monophosphatase from anabaena (nostoc) sp. pcc2 7120 Phyre2 PDB 2fvz chain B Region: 8 - 261 Aligned: 242 Modelled: 254 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: human inositol monophosphosphatase 2 Phyre2 PDB 5eq9 chain A Region: 7 - 262 Aligned: 240 Modelled: 250 Confidence: 100.0% Identity: 24% PDB header:biosynthetic protein Chain: A: PDB Molecule:inositol monophosphatase; PDBTitle: crystal structure of medicago truncatula histidinol-phosphate2 phosphatase (mthpp) in complex with l-histidinol phosphate and mg2+ Phyre2 PDB 1g0h chain A Region: 10 - 261 Aligned: 238 Modelled: 252 Confidence: 100.0% Identity: 24% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2pcr chain A Region: 7 - 263 Aligned: 231 Modelled: 254 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983)2 from aquifex aeolicus vf5 Phyre2 PDB 2q74 chain B Region: 7 - 264 Aligned: 233 Modelled: 246 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: mycobacterium tuberculosis suhb Phyre2 PDB 4gdg chain A Region: 7 - 264 Aligned: 251 Modelled: 258 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:3'(2'),5'-bisphosphate nucleotidase, putative; PDBTitle: structural and functional characterization of 3'(2'),5'-bisphosphate2 nucleotidase1 from entamoeba histolytica Phyre2 PDB 1vdw chain A Region: 7 - 263 Aligned: 239 Modelled: 241 Confidence: 100.0% Identity: 23% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1xi6 chain A Region: 7 - 258 Aligned: 225 Modelled: 225 Confidence: 100.0% Identity: 21% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 5djj chain A Region: 11 - 264 Aligned: 235 Modelled: 236 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:3'-phosphoadenosine 5'-phosphate phosphatase; PDBTitle: structure of m. tuberculosis cysq, a pap phosphatase with po4 and 2mg2 bound Phyre2 1 c3rydA_ 2 d2hhma_ 3 c2qflA_ 4 c3t0jB_ 5 c3qmfA_ 6 c2p3nB_ 7 c3luzA_ 8 c5zonA_ 9 c2czhB_ 10 c4n81A_ 11 c5zhhB_ 12 c2fvzB_ 13 c5eq9A_ 14 d1g0ha_ 15 c2pcrA_ 16 c2q74B_ 17 c4gdgA_ 18 d1vdwa_ 19 d1xi6a_ 20 c5djjA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99