1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	K	R	V	P	W	T	V	V	L	P	S	L	A	F	V	A	L	V	L	T	W	G	K	Q	I	G	P	V	V	G	L	L	A	A	V	L	L	A	G	A	V	L	A	A	V	N	H	A	E	V	V	A	A	R	V	G	E	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	G	S	L	V	L	A	V	A	V	T	T	I	E	V	A	L	I	V	A	L	M	V	S	G	G	D	D	A	A	T	L	A	R	D	T	V	F	A	A	V	M	I	T	T	N	G	I	A	G	L	S	L	L	L	G	S	L	R	Y
Secondary structure
SS confidence
Disorder																									?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	V	T	L	F	N	P	H	G	S	G	A	A	L	A	T	V	T	T	L	A	T	L	S	L	V	L	P	T	F	T	T	S	Q	S	G	P	E	L	S	P	G	Q	L	I	F	A	G	A	A	S	L	G	L	Y	V	L	F	L	F
Secondary structure
SS confidence
Disorder					?	?		?	?																						?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	Q	T	V	R	H	R	D	F	F	L	P	V	A	Q	K	G	A	V	E	D	D	S	H	A	D	P	P	S	T	R	A	A	L	L	S	L	G	L	L	L	V	A	L	V	A	V	V	G	L	A	K	V	E	S	P	V	I	E	E
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	V	S	A	A	G	F	P	Q	S	F	V	G	V	V	I	A	T	L	V	L	L	P	E	T	L	A	A	A	R	A	A	R	Q	G	R	L	Q	T	S	L	N	L	A	Y	G	S	A	M	A	S	I	G	L	T	I	P	T	I	A
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	A	S	L	W	L	S	G	P	L	Q	L	G	L	G	A	I	Q	L	V	L	L	V	L	T	V	V	V	S	V	L	T	V	V	P	G	R	A	T	R	L	Q	G	E	V	H	L	V	L	L	A	A	Y	L	F	L	A	V	V	P
Secondary structure
SS confidence
Disorder																																																										?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 4k1c chain B Region: 3 - 359 Aligned: 350 Modelled: 350 Confidence: 100.0% Identity: 18% PDB header:membrane protein/metal transport Chain: B: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 4k1c chain A Region: 3 - 359 Aligned: 351 Modelled: 351 Confidence: 100.0% Identity: 18% PDB header:membrane protein/metal transport Chain: A: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 4kjs chain B Region: 5 - 359 Aligned: 315 Modelled: 324 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:cation exchanger yfke; PDBTitle: structure of native yfke Phyre2 PDB 4kpp chain A Region: 5 - 358 Aligned: 337 Modelled: 337 Confidence: 100.0% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of h+/ca2+ exchanger cax Phyre2 PDB 3v5u chain A Region: 27 - 359 Aligned: 287 Modelled: 287 Confidence: 100.0% Identity: 19% PDB header:metal transport Chain: A: PDB Molecule:uncharacterized membrane protein mj0091; PDBTitle: structure of sodium/calcium exchanger from methanocaldococcus2 jannaschii dsm 2661 Phyre2 PDB 4dji chain A Region: 55 - 210 Aligned: 156 Modelled: 156 Confidence: 84.6% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 4r0c chain B Region: 154 - 293 Aligned: 140 Modelled: 140 Confidence: 51.7% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 3j1z chain P Region: 118 - 342 Aligned: 204 Modelled: 206 Confidence: 50.1% Identity: 13% PDB header:metal transport Chain: P: PDB Molecule:cation efflux family protein; PDBTitle: inward-facing conformation of the zinc transporter yiip revealed by2 cryo-electron microscopy Phyre2 PDB 4iu8 chain A Region: 195 - 257 Aligned: 63 Modelled: 63 Confidence: 46.8% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 1xrd chain A domain 1 Region: 316 - 343 Aligned: 28 Modelled: 28 Confidence: 44.2% Identity: 21% Fold: Light-harvesting complex subunits Superfamily: Light-harvesting complex subunits Family: Light-harvesting complex subunits Phyre2 PDB 1xrd chain A Region: 316 - 343 Aligned: 28 Modelled: 28 Confidence: 44.2% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:light-harvesting protein b-880, alpha chain; PDBTitle: light-harvesting complex 1 alfa subunit from wild-type2 rhodospirillum rubrum Phyre2 PDB 4iu9 chain A Region: 195 - 257 Aligned: 63 Modelled: 63 Confidence: 43.5% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter Phyre2 PDB 6et5 chain B Region: 316 - 343 Aligned: 28 Modelled: 28 Confidence: 33.5% Identity: 14% PDB header:photosynthesis Chain: B: PDB Molecule: PDBTitle: reaction centre light harvesting complex 1 from blc. virids Phyre2 PDB 6hwh chain X Region: 134 - 230 Aligned: 97 Modelled: 97 Confidence: 30.5% Identity: 12% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 4y7j chain E Region: 271 - 342 Aligned: 72 Modelled: 72 Confidence: 27.0% Identity: 11% PDB header:membrane protein,transport protein Chain: E: PDB Molecule:large conductance mechanosensitive channel protein, PDBTitle: structure of an archaeal mechanosensitive channel in expanded state Phyre2 PDB 3qnq chain D Region: 148 - 201 Aligned: 54 Modelled: 54 Confidence: 24.3% Identity: 13% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 2yvx chain D Region: 3 - 181 Aligned: 154 Modelled: 158 Confidence: 22.0% Identity: 15% PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte Phyre2 PDB 4r1i chain B Region: 165 - 293 Aligned: 129 Modelled: 129 Confidence: 17.2% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:aminobenzoyl-glutamate transporter; PDBTitle: structure and function of neisseria gonorrhoeae mtrf illuminates a2 class of antimetabolite efflux pumps Phyre2 PDB 2yvx chain A domain 3 Region: 3 - 181 Aligned: 153 Modelled: 158 Confidence: 16.3% Identity: 15% Fold: MgtE membrane domain-like Superfamily: MgtE membrane domain-like Family: MgtE membrane domain-like Phyre2 PDB 2oar chain A Region: 270 - 292 Aligned: 23 Modelled: 23 Confidence: 15.1% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) Phyre2 1 c4k1cB_ 2 c4k1cA_ 3 c4kjsB_ 4 c4kppA_ 5 c3v5uA_ 6 c4djiA_ 7 c4r0cB_ 8 c3j1zP_ 9 c4iu8A_ 10 d1xrda1 11 c1xrdA_ 12 c4iu9A_ 13 c6et5b_ 14 c6hwhX_ 15 c4y7jE_ 16 c3qnqD_ 17 c2yvxD_ 18 c4r1iB_ 19 d2yvxa3 20 c2oarA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34