1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	H	A	D	L	A	A	T	T	S	R	E	D	F	R	L	L	A	A	E	H	R	V	V	P	V	T	R	K	V	L	A	D	S	E	T	P	L	S	A	Y	R	K	L	A	A	N	R	P	G	T	F	L	L	E	S	A	E	N	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	S	W	S	R	W	S	F	I	G	A	G	A	P	T	A	L	T	V	R	E	G	Q	A	V	W	L	G	A	V	P	K	D	A	P	T	G	G	D	P	L	R	A	L	Q	V	T	L	E	L	L	A	T	A	D	R	Q	S	E	P
Secondary structure
SS confidence
Disorder		?	?	?																												?	?	?	?	?	?																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	P	P	L	S	G	G	M	V	G	F	F	A	Y	D	M	V	R	R	L	E	R	L	P	E	R	A	V	D	D	L	C	L	P	D	M	L	L	L	L	A	T	D	V	A	A	V	D	H	H	E	G	T	I	T	L	I	A	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	N	W	N	G	T	D	E	R	V	D	W	A	Y	D	D	A	V	A	R	L	D	V	M	T	A	A	L	G	Q	P	L	P	S	T	V	A	T	F	S	R	P	E	P	R	H	R	A	Q	R	T	V	E	E	Y	G	A	I	V
Secondary structure
SS confidence
Disorder					?	?	?																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	Y	L	V	D	Q	I	A	A	G	E	A	F	Q	V	V	P	S	Q	R	F	E	M	D	T	D	V	D	P	I	D	V	Y	R	I	L	R	V	T	N	P	S	P	Y	M	Y	L	L	Q	V	P	N	S	D	G	A	V	D	F	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	V	G	S	S	P	E	A	L	V	T	V	H	E	G	W	A	T	T	H	P	I	A	G	T	R	W	R	G	R	T	D	D	E	D	V	L	L	E	K	E	L	L	A	D	D	K	E	R	A	E	H	L	M	L	V	D	L	G	R
Secondary structure
SS confidence
Disorder																															?													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	D	L	G	R	V	C	T	P	G	T	V	R	V	E	D	Y	S	H	I	E	R	Y	S	H	V	M	H	L	V	S	T	V	T	G	K	L	G	E	G	R	T	A	L	D	A	V	T	A	C	F	P	A	G	T	L	S	G	A	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		K	V	R	A	M	E	L	I	E	E	V	E	K	T	R	R	G	L	Y	G	G	V	V	G	Y	L	D	F	A	G	N	A	D	F	A	I	A	I	R	T	A	L	M	R	N	G	T	A	Y	V	Q	A	G	G	G	V	V	A	D	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
Sequence		N	G	S	Y	E	Y	N	E	A	R	N	K	A	R	A	V	L	N	A	I	A	A	A	E	T	L	A	A	P	G	A	N	R	S	G	C
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 32%) Beta strand ( 27%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4pen chain A Region: 3 - 511 Aligned: 505 Modelled: 509 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component 1; PDBTitle: structure of anthranilate synthase component i (trpe) from2 mycobacterium tuberculosis with inhibitor bound Phyre2 PDB 1i1q chain A Region: 20 - 505 Aligned: 464 Modelled: 486 Confidence: 100.0% Identity: 41% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i7q chain A Region: 20 - 505 Aligned: 464 Modelled: 486 Confidence: 100.0% Identity: 40% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 5kck chain A Region: 26 - 498 Aligned: 433 Modelled: 473 Confidence: 100.0% Identity: 37% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i; PDBTitle: crystal structure of anthranilate synthase component i from2 streptococcus pneumoniae tigr4 Phyre2 PDB 1qdl chain A Region: 26 - 502 Aligned: 413 Modelled: 431 Confidence: 100.0% Identity: 39% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 4grh chain A Region: 30 - 501 Aligned: 427 Modelled: 443 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:aminodeoxychorismate synthase; PDBTitle: crystal structure of pabb of stenotrophomonas maltophilia Phyre2 PDB 1k0g chain A Region: 21 - 503 Aligned: 420 Modelled: 443 Confidence: 100.0% Identity: 33% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2g5f chain A domain 1 Region: 27 - 500 Aligned: 424 Modelled: 454 Confidence: 100.0% Identity: 26% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2i6y chain A Region: 30 - 500 Aligned: 407 Modelled: 438 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 2fn0 chain A domain 1 Region: 31 - 500 Aligned: 397 Modelled: 420 Confidence: 100.0% Identity: 25% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3h9m chain A Region: 39 - 501 Aligned: 379 Modelled: 387 Confidence: 100.0% Identity: 24% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase, component i from2 cytophaga hutchinsonii Phyre2 PDB 3bzn chain A domain 1 Region: 20 - 501 Aligned: 405 Modelled: 434 Confidence: 100.0% Identity: 21% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3hwo chain B Region: 68 - 502 Aligned: 368 Modelled: 383 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 3os6 chain A Region: 216 - 502 Aligned: 283 Modelled: 286 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 3gse chain A Region: 26 - 496 Aligned: 398 Modelled: 432 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 3r74 chain B Region: 216 - 508 Aligned: 283 Modelled: 293 Confidence: 100.0% Identity: 27% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 3nqk chain A Region: 437 - 473 Aligned: 37 Modelled: 37 Confidence: 38.8% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 1cvr chain A domain 1 Region: 439 - 481 Aligned: 38 Modelled: 43 Confidence: 34.6% Identity: 24% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Gingipain R (RgpB), C-terminal domain Phyre2 PDB 2gut chain A Region: 193 - 249 Aligned: 55 Modelled: 57 Confidence: 28.3% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:arc/mediator, positive cofactor 2 glutamine/q- PDBTitle: solution structure of the trans-activation domain of the2 human co-activator arc105 Phyre2 PDB 1ugp chain A Region: 334 - 390 Aligned: 43 Modelled: 57 Confidence: 26.9% Identity: 40% Fold: Nitrile hydratase alpha chain Superfamily: Nitrile hydratase alpha chain Family: Nitrile hydratase alpha chain Phyre2 1 c4penA_ 2 d1i1qa_ 3 d1i7qa_ 4 c5kckA_ 5 d1qdla_ 6 c4grhA_ 7 d1k0ga_ 8 d2g5fa1 9 c2i6yA_ 10 d2fn0a1 11 c3h9mA_ 12 d3bzna1 13 c3hwoB_ 14 c3os6A_ 15 c3gseA_ 16 c3r74B_ 17 c3nqkA_ 18 d1cvra1 19 c2gutA_ 20 d1ugpa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79