1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	L	Q	E	L	W	F	G	V	I	A	A	L	F	L	G	F	F	I	L	E	G	F	D	F	G	V	G	M	L	M	A	P	F	A	H	V	G	M	G	D	P	E	T	H	R	R	T	A	L	N	T	I	G	P	V	W	D	G
Secondary structure
SS confidence
Disorder		?	?																																	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	E	V	W	L	I	T	A	G	A	A	I	F	A	A	F	P	G	W	Y	A	T	V	F	S	A	L	Y	L	P	L	L	A	I	L	F	G	M	I	L	R	A	V	A	I	E	W	R	G	K	I	D	D	P	K	W	R	T	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	F	G	I	A	A	G	S	W	L	P	A	L	L	W	G	V	A	F	A	I	L	V	R	G	L	P	V	D	A	N	G	H	V	A	L	S	I	P	D	V	L	N	A	Y	T	L	L	G	G	L	A	T	A	G	L	F	S	L	Y
Secondary structure
SS confidence
Disorder																								?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	A	V	F	I	A	L	K	T	S	G	P	I	R	D	D	A	Y	R	F	A	V	W	L	S	L	P	V	A	G	L	V	A	G	F	G	L	W	T	Q	L	A	Y	G	K	D	W	T	W	L	V	L	A	V	A	G	C	A	Q	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	T	V	L	V	W	R	R	V	S	D	G	W	A	F	M	C	T	L	I	V	V	A	A	V	V	V	L	L	F	G	A	L	Y	P	N	L	V	P	S	T	L	N	P	Q	W	S	L	T	I	H	N	A	S	S	T	P	Y	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.
Sequence		L	K	I	M	T	W	V	T	A	F	F	A	P	L	T	V	A	Y	Q	T	W	T	Y	W	V	F	R	Q	R	I	S	A	E	R	I	P	P	P	T	G	L	A	R	R	A	P
Secondary structure
SS confidence
Disorder																																?				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 73%) Beta strand ( 1%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 5ir6 chain B Region: 1 - 329 Aligned: 319 Modelled: 329 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 6cfw chain G Region: 231 - 336 Aligned: 106 Modelled: 106 Confidence: 87.9% Identity: 10% PDB header:membrane protein Chain: G: PDB Molecule:monovalent cation/h+ antiporter subunit c; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 6f0k chain C Region: 77 - 341 Aligned: 257 Modelled: 265 Confidence: 71.6% Identity: 10% PDB header:membrane protein Chain: C: PDB Molecule:polysulphide reductase nrfd; PDBTitle: alternative complex iii Phyre2 PDB 3m7e chain A Region: 130 - 337 Aligned: 187 Modelled: 192 Confidence: 57.5% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha Phyre2 PDB 3m7b chain A Region: 130 - 337 Aligned: 187 Modelled: 192 Confidence: 57.5% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha Phyre2 PDB 2yev chain B Region: 286 - 344 Aligned: 59 Modelled: 59 Confidence: 45.1% Identity: 14% PDB header:electron transport Chain: B: PDB Molecule:cytochrome c oxidase subunit 2; PDBTitle: structure of caa3-type cytochrome oxidase Phyre2 PDB 4dji chain A Region: 230 - 346 Aligned: 103 Modelled: 117 Confidence: 35.3% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 1fft chain B domain 2 Region: 281 - 341 Aligned: 58 Modelled: 61 Confidence: 34.1% Identity: 19% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 5ir6 chain A Region: 9 - 329 Aligned: 315 Modelled: 315 Confidence: 29.3% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:bd-type quinol oxidase subunit i; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 6f0k chain F Region: 85 - 312 Aligned: 225 Modelled: 228 Confidence: 26.6% Identity: 12% PDB header:membrane protein Chain: F: PDB Molecule:actf; PDBTitle: alternative complex iii Phyre2 PDB 1ejx chain C domain 2 Region: 272 - 303 Aligned: 32 Modelled: 32 Confidence: 24.2% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: alpha-subunit of urease, catalytic domain Phyre2 PDB 5wud chain A Region: 26 - 76 Aligned: 36 Modelled: 36 Confidence: 24.1% Identity: 28% PDB header:membrane protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structural basis for conductance through tric cation channels Phyre2 PDB 1e9y chain B domain 2 Region: 272 - 303 Aligned: 32 Modelled: 32 Confidence: 22.3% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: alpha-subunit of urease, catalytic domain Phyre2 PDB 4lhd chain B Region: 35 - 55 Aligned: 21 Modelled: 21 Confidence: 18.9% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:glycine dehydrogenase [decarboxylating]; PDBTitle: crystal structure of synechocystis sp. pcc 6803 glycine decarboxylase2 (p-protein), holo form with pyridoxal-5'-phosphate and glycine,3 closed flexible loop Phyre2 PDB 4rym chain A Region: 128 - 251 Aligned: 117 Modelled: 124 Confidence: 18.1% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:integral membrane protein; PDBTitle: crystal structure of bctspo iodo type1 monomer Phyre2 PDB 2r6g chain F domain 1 Region: 206 - 294 Aligned: 89 Modelled: 89 Confidence: 17.7% Identity: 13% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 1ar1 chain B Region: 284 - 341 Aligned: 58 Modelled: 58 Confidence: 16.6% Identity: 9% PDB header:complex (oxidoreductase/antibody) Chain: B: PDB Molecule:cytochrome c oxidase; PDBTitle: structure at 2.7 angstrom resolution of the paracoccus2 denitrificans two-subunit cytochrome c oxidase complexed3 with an antibody fv fragment Phyre2 PDB 1qle chain B Region: 284 - 341 Aligned: 58 Modelled: 58 Confidence: 16.6% Identity: 9% PDB header:oxidoreductase/immune system Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: cryo-structure of the paracoccus denitrificans four-subunit cytochrome2 c oxidase in the completely oxidized state complexed with an antibody3 fv fragment Phyre2 PDB 5fay chain A Region: 43 - 63 Aligned: 21 Modelled: 21 Confidence: 14.9% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:choline trimethylamine-lyase; PDBTitle: y208f mutant of choline tma-lyase Phyre2 PDB 2bo9 chain B Region: 323 - 343 Aligned: 21 Modelled: 21 Confidence: 11.4% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:human latexin; PDBTitle: human carboxypeptidase a4 in complex with human latexin. Phyre2 1 c5ir6B_ 2 c6cfwG_ 3 c6f0kC_ 4 c3m7eA_ 5 c3m7bA_ 6 c2yevB_ 7 c4djiA_ 8 d1fftb2 9 c5ir6A_ 10 c6f0kF_ 11 d1ejxc2 12 c5wudA_ 13 d1e9yb2 14 c4lhdB_ 15 c4rymA_ 16 d2r6gf1 17 c1ar1B_ 18 c1qleB_ 19 c5fayA_ 20 c2bo9B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44