1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	A	V	D	E	Y	T	V	H	P	W	G	L	Y	L	A	R	P	T	P	G	R	A	Q	F	H	Y	L	E	S	W	L	L	P	S	L	G	L	R	A	T	V	F	H	F	N	P	S	H	K	R	D	H	D	Y	Y	L	D	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																											?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	E	Y	T	P	G	P	S	V	W	R	S	E	D	H	Y	L	D	I	E	V	R	T	G	G	G	A	E	L	A	D	V	D	E	L	L	D	A	V	R	H	G	L	L	T	P	T	V	A	E	Q	A	V	R	H	A	V	D	A	V
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.
Sequence		E	G	L	A	R	N	G	Y	D	L	T	R	W	L	A	T	K	G	M	E	L	T	W	R	S	G	S
Secondary structure
SS confidence
Disorder								?																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 24%) Beta strand ( 37%)

Rank Aligned region

PDB 2p12 chain A domain 1 Region: 1 - 144 Aligned: 143 Modelled: 144 Confidence: 100.0% Identity: 59% Fold: FomD barrel-like Superfamily: FomD-like Family: FomD-like Phyre2 PDB 3exm chain A Region: 42 - 129 Aligned: 88 Modelled: 88 Confidence: 99.6% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:phosphatase sc4828; PDBTitle: crystal structure of the phosphatase sc4828 with the non-hydrolyzable2 nucleotide gpcp Phyre2 PDB 5zdn chain A Region: 1 - 146 Aligned: 145 Modelled: 146 Confidence: 99.5% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:fomd; PDBTitle: the complex structure of fomd with cdp Phyre2 PDB 1rrj chain A Region: 4 - 43 Aligned: 37 Modelled: 40 Confidence: 83.6% Identity: 16% PDB header:isomerase/dna Chain: A: PDB Molecule:dna topoisomerase i; PDBTitle: structural mechanisms of camptothecin resistance by2 mutations in human topoisomerase i Phyre2 PDB 1a31 chain A Region: 4 - 43 Aligned: 37 Modelled: 38 Confidence: 81.8% Identity: 16% PDB header:isomerase/dna Chain: A: PDB Molecule:protein (topoisomerase i); PDBTitle: human reconstituted dna topoisomerase i in covalent complex2 with a 22 base pair dna duplex Phyre2 PDB 1nh3 chain A Region: 4 - 43 Aligned: 37 Modelled: 40 Confidence: 81.3% Identity: 16% PDB header:isomerase/dna Chain: A: PDB Molecule:dna topoisomerase i; PDBTitle: human topoisomerase i ara-c complex Phyre2 PDB 1k4t chain A domain 3 Region: 4 - 43 Aligned: 37 Modelled: 40 Confidence: 81.1% Identity: 16% Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Phyre2 PDB 2b9s chain A Region: 4 - 43 Aligned: 37 Modelled: 40 Confidence: 74.3% Identity: 22% PDB header:isomerase/dna Chain: A: PDB Molecule:topoisomerase i-like protein; PDBTitle: crystal structure of heterodimeric l. donovani topoisomerase i-2 vanadate-dna complex Phyre2 PDB 1ois chain A Region: 4 - 43 Aligned: 37 Modelled: 40 Confidence: 73.9% Identity: 19% Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Phyre2 PDB 5htl chain A Region: 99 - 139 Aligned: 34 Modelled: 41 Confidence: 50.3% Identity: 26% PDB header:biosynthetic protein Chain: A: PDB Molecule:msha biogenesis protein mshe; PDBTitle: structure of mshe with cdg Phyre2 PDB 1nvp chain D domain 1 Region: 92 - 127 Aligned: 36 Modelled: 36 Confidence: 40.0% Identity: 17% Fold: Transcription factor IIA (TFIIA), alpha-helical domain Superfamily: Transcription factor IIA (TFIIA), alpha-helical domain Family: Transcription factor IIA (TFIIA), alpha-helical domain Phyre2 PDB 1nh2 chain D domain 1 Region: 92 - 126 Aligned: 35 Modelled: 35 Confidence: 40.0% Identity: 17% Fold: Transcription factor IIA (TFIIA), alpha-helical domain Superfamily: Transcription factor IIA (TFIIA), alpha-helical domain Family: Transcription factor IIA (TFIIA), alpha-helical domain Phyre2 PDB 3wo8 chain B Region: 77 - 141 Aligned: 64 Modelled: 65 Confidence: 39.1% Identity: 9% PDB header:hydrolase Chain: B: PDB Molecule:beta-n-acetylglucosaminidase; PDBTitle: crystal structure of the beta-n-acetylglucosaminidase from thermotoga2 maritima Phyre2 PDB 5bza chain A Region: 77 - 123 Aligned: 47 Modelled: 47 Confidence: 38.4% Identity: 9% PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: crystal structure of cbsa from thermotoga neapolitana Phyre2 PDB 5mj1 chain A Region: 16 - 32 Aligned: 17 Modelled: 17 Confidence: 33.7% Identity: 35% PDB header:immune system Chain: A: PDB Molecule:cd83 antigen; PDBTitle: extracellular domain of human cd83 - rhombohedral crystal form Phyre2 PDB 3cr8 chain C Region: 84 - 130 Aligned: 47 Modelled: 47 Confidence: 33.3% Identity: 17% PDB header:transferase Chain: C: PDB Molecule:sulfate adenylyltransferase, adenylylsulfate kinase; PDBTitle: hexameric aps kinase from thiobacillus denitrificans Phyre2 PDB 5mz2 chain I Region: 12 - 38 Aligned: 27 Modelled: 27 Confidence: 32.7% Identity: 19% PDB header:photosynthesis Chain: I: PDB Molecule:rubisco small subunit; PDBTitle: rubisco from thalassiosira antarctica Phyre2 PDB 1bwv chain S Region: 12 - 38 Aligned: 27 Modelled: 27 Confidence: 32.5% Identity: 19% Fold: RuBisCO, small subunit Superfamily: RuBisCO, small subunit Family: RuBisCO, small subunit Phyre2 PDB 5nv3 chain P Region: 12 - 40 Aligned: 29 Modelled: 29 Confidence: 32.3% Identity: 28% PDB header:lyase Chain: P: PDB Molecule:ribulose bisphosphate carboxylase small chain 1; PDBTitle: structure of rubisco from rhodobacter sphaeroides in complex with cabp Phyre2 PDB 1bxn chain I Region: 12 - 40 Aligned: 29 Modelled: 29 Confidence: 32.0% Identity: 28% Fold: RuBisCO, small subunit Superfamily: RuBisCO, small subunit Family: RuBisCO, small subunit Phyre2 1 d2p12a1 2 c3exmA_ 3 c5zdnA_ 4 c1rrjA_ 5 c1a31A_ 6 c1nh3A_ 7 d1k4ta3 8 c2b9sA_ 9 d1oisa_ 10 c5htlA_ 11 d1nvpd1 12 d1nh2d1 13 c3wo8B_ 14 c5bzaA_ 15 c5mj1A_ 16 c3cr8C_ 17 c5mz2I_ 18 d1bwvs_ 19 c5nv3P_ 20 d1bxni_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99