1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		I	S	T	E	T	R	V	N	E	R	I	R	V	P	E	V	R	L	I	G	P	G	G	E	Q	V	G	I	V	R	I	E	D	A	L	R	V	A	A	D	A	D	L	D	L	V	E	V	A	P	N	A	R	P	P	V	C	K	I	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?															?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	Y	G	K	Y	K	Y	E	A	A	Q	K	A	R	E	S	R	R	N	Q	Q	Q	T	V	V	K	E	Q	K	L	R	P	K	I	D	D	H	D	Y	E	T	K	K	G	H	V	V	R	F	L	E	A	G	S	K	V	K	V	T	I
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	F	R	G	R	E	Q	S	R	P	E	L	G	Y	R	L	L	Q	R	L	G	A	D	V	A	D	Y	G	F	I	E	T	S	A	K	Q	D	G	R	N	M	T	M	V	L	A	P	H	R	G	A	K	T	R	A	R	A	R	H	P
Secondary structure
SS confidence
Disorder						?	?	?	?	?																				?	?	?	?	?	?	?	?		?										?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.
Sequence		G	E	P	A	G	G	P	P	P	K	P	T	A	G	D	S	K	A	A	P	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 33%) Beta strand ( 21%)

Rank Aligned region

PDB 5lmt chain X Region: 3 - 169 Aligned: 163 Modelled: 167 Confidence: 100.0% Identity: 53% PDB header:ribosome Chain: X: PDB Molecule:translation initiation factor if-3; PDBTitle: structure of bacterial 30s-if1-if3-mrna-trna translation pre-2 initiation complex(state-3) Phyre2 PDB 6nf8 chain Z Region: 5 - 184 Aligned: 180 Modelled: 180 Confidence: 100.0% Identity: 17% PDB header:ribosomal protein Chain: Z: PDB Molecule: PDBTitle: structure of human mitochondrial translation initiation factor 3 bound2 to the small ribosomal subunit -class i Phyre2 PDB 2crq chain A Region: 75 - 178 Aligned: 104 Modelled: 104 Confidence: 100.0% Identity: 19% PDB header:translation Chain: A: PDB Molecule:mitochondrial translational initiation factor 3; PDBTitle: solution structure of c-terminal domain of riken cdna2 2810012l14 Phyre2 PDB 2m71 chain A Region: 81 - 176 Aligned: 96 Modelled: 96 Confidence: 100.0% Identity: 27% PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-3; PDBTitle: solution structure of the a c-terminal domain of translation2 initiation factor if-3 from campylobacter jejuni Phyre2 PDB 1tig chain A Region: 83 - 170 Aligned: 88 Modelled: 88 Confidence: 100.0% Identity: 48% Fold: IF3-like Superfamily: Translation initiation factor IF3, C-terminal domain Family: Translation initiation factor IF3, C-terminal domain Phyre2 PDB 2ife chain A Region: 82 - 171 Aligned: 90 Modelled: 90 Confidence: 100.0% Identity: 41% Fold: IF3-like Superfamily: Translation initiation factor IF3, C-terminal domain Family: Translation initiation factor IF3, C-terminal domain Phyre2 PDB 1tif chain A Region: 3 - 78 Aligned: 76 Modelled: 76 Confidence: 100.0% Identity: 53% Fold: beta-Grasp (ubiquitin-like) Superfamily: Translation initiation factor IF3, N-terminal domain Family: Translation initiation factor IF3, N-terminal domain Phyre2 PDB 1i96 chain V Region: 84 - 169 Aligned: 86 Modelled: 82 Confidence: 99.9% Identity: 55% Fold: IF3-like Superfamily: Translation initiation factor IF3, C-terminal domain Family: Translation initiation factor IF3, C-terminal domain Phyre2 PDB 6o6d chain A Region: 4 - 68 Aligned: 65 Modelled: 65 Confidence: 99.9% Identity: 43% PDB header:ligase Chain: A: PDB Molecule:translation initiation factor if-3; PDBTitle: n-terminal domain of translation initiation factor if-3 from2 helicobacter pylori Phyre2 PDB 2oux chain A domain 2 Region: 12 - 40 Aligned: 29 Modelled: 29 Confidence: 50.0% Identity: 24% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 2m4i chain A Region: 98 - 142 Aligned: 44 Modelled: 45 Confidence: 47.8% Identity: 14% PDB header:cell cycle Chain: A: PDB Molecule:septum site-determining protein minc; PDBTitle: solution structure of bacillus subtilis minc n-terminal domain Phyre2 PDB 2yvx chain A domain 2 Region: 12 - 40 Aligned: 29 Modelled: 29 Confidence: 47.5% Identity: 28% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 1vr9 chain A domain 3 Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 47.5% Identity: 20% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 1vr9 chain B Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 45.9% Identity: 20% PDB header:unknown function Chain: B: PDB Molecule:cbs domain protein/act domain protein; PDBTitle: crystal structure of a cbs domain pair/act domain protein (tm0892)2 from thermotoga maritima at 1.70 a resolution Phyre2 PDB 1zfj chain A domain 4 Region: 12 - 39 Aligned: 28 Modelled: 28 Confidence: 45.1% Identity: 25% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 3lhh chain A Region: 12 - 36 Aligned: 25 Modelled: 22 Confidence: 43.1% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:cbs domain protein; PDBTitle: the crystal structure of cbs domain protein from shewanella2 oneidensis mr-1. Phyre2 PDB 5ks7 chain A Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 41.1% Identity: 17% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:carnitine transport atp-binding protein opuca; PDBTitle: crystal structure of listeria monocytogenes opuca cbs domain dimer in2 complex with cyclic-di-amp Phyre2 PDB 3jtf chain B Region: 12 - 36 Aligned: 25 Modelled: 25 Confidence: 39.7% Identity: 32% PDB header:transport protein Chain: B: PDB Molecule:magnesium and cobalt efflux protein; PDBTitle: the cbs domain pair structure of a magnesium and cobalt efflux protein2 from bordetella parapertussis in complex with amp Phyre2 PDB 2rih chain A domain 1 Region: 12 - 36 Aligned: 25 Modelled: 25 Confidence: 39.6% Identity: 28% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 2oox chain E domain 2 Region: 12 - 36 Aligned: 25 Modelled: 25 Confidence: 38.1% Identity: 24% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 1 c5lmtX_ 2 c6nf8z_ 3 c2crqA_ 4 c2m71A_ 5 d1tiga_ 6 d2ifea_ 7 d1tifa_ 8 d1i96v_ 9 c6o6dA_ 10 d2ouxa2 11 c2m4iA_ 12 d2yvxa2 13 d1vr9a3 14 c1vr9B_ 15 d1zfja4 16 c3lhhA_ 17 c5ks7A_ 18 c3jtfB_ 19 d2riha1 20 d2ooxe2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99