1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	T	E	R	S	A	R	V	A	T	A	V	K	L	H	R	H	V	G	R	R	R	A	G	R	F	L	A	E	G	P	N	L	V	A	A	A	L	A	R	G	L	V	R	E	V	F	V	T	E	V	A	A	R	R	H	E	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	A	H	E	A	S	V	H	L	V	T	E	R	A	A	K	A	L	S	D	T	V	T	P	A	G	L	V	A	V	C	D	L	P	A	T	R	L	E	D	V	L	A	G	S	P	Q	L	I	A	V	T	V	E	I	R	E	P	G
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	A	G	T	V	I	R	I	A	D	A	M	G	A	A	A	V	I	L	A	G	R	S	V	D	P	Y	N	G	K	C	L	R	A	S	T	G	S	I	F	A	I	P	V	V	V	A	P	D	V	G	A	A	I	A	D	L	R	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	L	Q	V	L	A	T	A	V	D	G	E	M	A	L	D	D	A	D	R	L	L	A	E	P	T	A	W	L	F	G	P	E	A	H	G	L	S	A	E	I	A	A	L	A	D	H	R	V	H	I	L	M	S	G	G	A	E	S	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260
Sequence		N	V	A	A	A	A	A	I	C	L	Y	E	S	A	R	A	L	G	R	R
Secondary structure
SS confidence
Disorder																		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 39%) Beta strand ( 20%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 1ipa chain A Region: 1 - 257 Aligned: 253 Modelled: 253 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase Phyre2 PDB 4x3m chain B Region: 1 - 258 Aligned: 253 Modelled: 253 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:rna 2'-o ribose methyltransferase; PDBTitle: crystal structure of ttha0275 from thermus thermophilus (hb8) in2 complex with adenosine in space group p212121 Phyre2 PDB 5kzk chain A Region: 1 - 257 Aligned: 254 Modelled: 257 Confidence: 100.0% Identity: 32% PDB header:rna binding protein Chain: A: PDB Molecule:probable rna methyltransferase, trmh family; PDBTitle: crystal structure of rrna methyltransferase from sinorhizobium2 meliloti Phyre2 PDB 2i6d chain A Region: 3 - 256 Aligned: 248 Modelled: 242 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. Phyre2 PDB 3gyq chain B Region: 2 - 257 Aligned: 253 Modelled: 253 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 1x7p chain B Region: 6 - 257 Aligned: 244 Modelled: 244 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet Phyre2 PDB 1gz0 chain H Region: 21 - 258 Aligned: 236 Modelled: 227 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: H: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1gz0 chain G Region: 93 - 258 Aligned: 164 Modelled: 157 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1gz0 chain A domain 1 Region: 93 - 258 Aligned: 164 Modelled: 157 Confidence: 100.0% Identity: 23% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 5co4 chain A Region: 105 - 260 Aligned: 152 Modelled: 152 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:putative trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: structural insights into the 2-oh methylation of c/u34 on trna Phyre2 PDB 1ipa chain A domain 1 Region: 98 - 257 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 38% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1zjr chain A Region: 104 - 260 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme Phyre2 PDB 1v2x chain A Region: 104 - 257 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 33% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 2ha8 chain A Region: 104 - 257 Aligned: 152 Modelled: 152 Confidence: 100.0% Identity: 23% PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 Phyre2 PDB 4pzk chain A Region: 108 - 259 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: crystal strucrure of putative rna methyltransferase from bacillus2 anthracis. Phyre2 PDB 1mxi chain A Region: 109 - 258 Aligned: 146 Modelled: 146 Confidence: 100.0% Identity: 21% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 3onp chain A Region: 108 - 256 Aligned: 148 Modelled: 149 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides Phyre2 PDB 3ic6 chain A Region: 108 - 259 Aligned: 150 Modelled: 150 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae Phyre2 PDB 5gm8 chain A Region: 108 - 257 Aligned: 148 Modelled: 149 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine/uridine-2'-o-)-methyltransferase trmj; PDBTitle: methylation at position 32 of trna catalyzed by trmj alters oxidative2 stress response in pseudomonas aeruiginosa Phyre2 PDB 4cng chain B Region: 108 - 255 Aligned: 145 Modelled: 145 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:spou rrna methylase; PDBTitle: crystal structure of sulfolobus acidocaldarius trmj in2 complex with s-adenosyl-l-homocysteine Phyre2 1 c1ipaA_ 2 c4x3mB_ 3 c5kzkA_ 4 c2i6dA_ 5 c3gyqB_ 6 c1x7pB_ 7 c1gz0H_ 8 c1gz0G_ 9 d1gz0a1 10 c5co4A_ 11 d1ipaa1 12 c1zjrA_ 13 d1v2xa_ 14 c2ha8A_ 15 c4pzkA_ 16 d1mxia_ 17 c3onpA_ 18 c3ic6A_ 19 c5gm8A_ 20 c4cngB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104