1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	V	A	S	R	T	S	A	D	P	L	G	P	D	S	L	T	W	K	Y	F	G	D	L	R	T	G	M	M	G	V	W	I	G	A	I	Q	N	M	Y	P	E	L	G	A	G	V	E	E	H	S	I	L	L	R	E	P	L	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	V	A	R	S	V	Y	P	I	M	G	V	V	Y	D	G	D	R	A	A	Q	T	G	Q	Q	I	K	G	Y	H	R	T	I	K	G	V	D	A	E	G	R	R	Y	H	A	L	N	P	D	T	F	Y	W	A	H	A	T	F	F	M
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	V	I	K	V	A	E	Y	F	C	G	G	L	T	E	A	E	K	H	Q	L	F	E	E	H	V	R	W	Y	R	M	Y	G	M	S	M	R	P	V	P	K	S	W	E	D	F	Q	D	Y	W	D	R	V	C	R	D	K	L	E	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	Q	A	T	V	D	I	L	Q	M	R	I	P	K	P	R	F	V	L	M	P	T	P	I	W	D	Q	L	F	K	P	L	I	A	G	Q	R	W	I	A	A	G	L	F	D	P	A	V	R	E	K	A	G	M	H	W	T	P	G	D
Secondary structure
SS confidence
Disorder																?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	V	L	L	R	V	F	G	K	V	V	E	L	A	F	L	A	V	P	D	E	I	R	L	H	P	R	A	L	A	A	Y	R	R	A	A	G	R	T	R	H	D	A	P	L	V	Q	A	P	G	F	M	A	P	P	R	D	R	Q	G
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.
Sequence		L	P	M	H	Y	F	P	P	R	S	H	R	F	T	R	S	A	L	D	P	A	K	A	L	M	E	R	A	G	A	L	V	H	S	T	L	S	L	A	G	V	R	P	A	R	G	P	S	R	A	A
Secondary structure
SS confidence
Disorder		?								?	?			?	?																								?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 64%) Beta strand ( 0%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 5o1m chain A Region: 19 - 259 Aligned: 231 Modelled: 241 Confidence: 99.2% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:rubber oxygenase; PDBTitle: structure of latex clearing protein lcp in the closed state Phyre2 PDB 2ru8 chain A Region: 143 - 172 Aligned: 30 Modelled: 30 Confidence: 31.5% Identity: 17% PDB header:replication Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: dnat c-terminal domain Phyre2 PDB 6akm chain A Region: 318 - 341 Aligned: 24 Modelled: 24 Confidence: 24.9% Identity: 33% PDB header:protein binding Chain: A: PDB Molecule:suppressor of ikbke 1; PDBTitle: crystal structure of slmap-sike1 complex Phyre2 PDB 2e8m chain A Region: 103 - 162 Aligned: 60 Modelled: 60 Confidence: 22.5% Identity: 18% PDB header:signaling protein Chain: A: PDB Molecule:epidermal growth factor receptor kinase PDBTitle: solution structure of the c-terminal sam-domain of2 epidermal growth receptor pathway substrate 8 Phyre2 PDB 5xaz chain D Region: 16 - 187 Aligned: 172 Modelled: 172 Confidence: 20.7% Identity: 12% PDB header:dna binding protein Chain: D: PDB Molecule:gamma-butyrolactone receptor protein; PDBTitle: crystal structure of full length native tylp, a tetr regulator from2 streptomyces fradiae Phyre2 PDB 4ou6 chain A Region: 143 - 172 Aligned: 30 Modelled: 30 Confidence: 17.5% Identity: 13% PDB header:replication/dna Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: crystal structure of dnat84-153-dt10 ssdna complex form 1 Phyre2 PDB 4wiu chain A Region: 91 - 163 Aligned: 67 Modelled: 73 Confidence: 17.0% Identity: 18% PDB header:lyase,transferase Chain: A: PDB Molecule:phosphoenolpyruvate carboxykinase [gtp]; PDBTitle: crystal structure of pepck (rv0211) from mycobacterium tuberculosis in2 complex with oxalate and mn2+ Phyre2 PDB 1g73 chain A Region: 121 - 144 Aligned: 24 Modelled: 24 Confidence: 14.4% Identity: 8% Fold: Spectrin repeat-like Superfamily: Smac/diablo Family: Smac/diablo Phyre2 PDB 5fcm chain B Region: 319 - 338 Aligned: 20 Modelled: 20 Confidence: 13.7% Identity: 30% PDB header:cell cycle Chain: B: PDB Molecule:basal body protein; PDBTitle: crbld10-n 1-70 Phyre2 PDB 1nex chain C Region: 206 - 246 Aligned: 41 Modelled: 41 Confidence: 13.4% Identity: 17% PDB header:ligase, cell cycle Chain: C: PDB Molecule:centromere dna-binding protein complex cbf3 PDBTitle: crystal structure of scskp1-sccdc4-cpd peptide complex Phyre2 PDB 1unh chain D Region: 108 - 152 Aligned: 45 Modelled: 45 Confidence: 13.0% Identity: 7% PDB header:cell cycle Chain: D: PDB Molecule:cyclin-dependent kinase 5 activator 1; PDBTitle: structural mechanism for the inhibition of cdk5-p25 by2 roscovitine, aloisine and indirubin. Phyre2 PDB 2ovq chain A Region: 225 - 246 Aligned: 22 Modelled: 22 Confidence: 12.9% Identity: 18% PDB header:transcription/cell cycle Chain: A: PDB Molecule:s-phase kinase-associated protein 1a; PDBTitle: structure of the skp1-fbw7-cyclinedegc complex Phyre2 PDB 1unl chain D Region: 108 - 152 Aligned: 45 Modelled: 45 Confidence: 12.7% Identity: 7% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 1v7b chain A domain 2 Region: 104 - 148 Aligned: 45 Modelled: 45 Confidence: 11.9% Identity: 9% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 3m20 chain A Region: 130 - 159 Aligned: 30 Modelled: 30 Confidence: 11.7% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:4-oxalocrotonate tautomerase, putative; PDBTitle: crystal structure of dmpi from archaeoglobus fulgidus determined to2 2.37 angstroms resolution Phyre2 PDB 1u7k chain A Region: 109 - 148 Aligned: 40 Modelled: 40 Confidence: 11.3% Identity: 15% Fold: Retrovirus capsid protein, N-terminal core domain Superfamily: Retrovirus capsid protein, N-terminal core domain Family: Retrovirus capsid protein, N-terminal core domain Phyre2 PDB 5cuv chain B Region: 122 - 170 Aligned: 40 Modelled: 49 Confidence: 10.8% Identity: 18% PDB header:metal binding protein Chain: B: PDB Molecule:acidocalcisomal pyrophosphatase; PDBTitle: crystal structure of trypanosoma cruzi vacuolar soluble2 pyrophosphatases in apo form Phyre2 PDB 4nk1 chain B Region: 132 - 173 Aligned: 38 Modelled: 42 Confidence: 10.5% Identity: 11% PDB header:oxygen binding Chain: B: PDB Molecule:hemoglobin-like protein; PDBTitle: crystal structure of phosphate-bound hell's gate globin iv Phyre2 PDB 3ucs chain B Region: 215 - 252 Aligned: 38 Modelled: 38 Confidence: 10.4% Identity: 5% PDB header:chaperone Chain: B: PDB Molecule:chaperone-modulator protein cbpm; PDBTitle: crystal structure of the complex between cbpa j-domain and cbpm Phyre2 PDB 1few chain A Region: 121 - 144 Aligned: 24 Modelled: 24 Confidence: 9.3% Identity: 8% Fold: Spectrin repeat-like Superfamily: Smac/diablo Family: Smac/diablo Phyre2 1 c5o1mA_ 2 c2ru8A_ 3 c6akmA_ 4 c2e8mA_ 5 c5xazD_ 6 c4ou6A_ 7 c4wiuA_ 8 d1g73a_ 9 c5fcmB_ 10 c1nexC_ 11 c1unhD_ 12 c2ovqA_ 13 d1unld_ 14 d1v7ba2 15 c3m20A_ 16 d1u7ka_ 17 c5cuvB_ 18 c4nk1B_ 19 c3ucsB_ 20 d1fewa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59