1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	T	I	A	A	S	P	T	H	N	A	L	G	K	A	A	R	R	L	L	P	L	L	F	V	L	Y	V	I	N	F	V	D	R	A	N	I	S	V	A	A	L	A	M	N	A	D	L	R	L	S	A	T	A	Y	G	T	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	F	F	L	G	Y	V	L	F	Q	V	P	A	N	A	A	L	A	R	F	G	A	G	R	T	L	T	A	V	V	L	A	W	G	V	C	S	A	A	T	A	L	V	T	S	A	H	T	L	Y	L	A	R	F	A	L	G	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	G	G	F	F	P	G	V	I	A	Y	L	T	V	W	F	P	C	A	Q	R	A	R	A	V	A	T	F	L	L	A	I	P	V	A	N	T	V	G	L	P	L	S	G	L	I	V	G	H	V	H	M	A	G	L	P	G	W	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	F	V	I	E	A	L	P	A	L	L	L	A	P	L	L	R	R	L	L	P	D	N	P	Q	R	A	S	W	L	T	P	E	E	R	A	E	L	S	A	R	L	T	E	D	T	P	A	P	T	G	R	S	S	G	A	G	W	D	L
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	F	A	V	V	Y	G	G	L	Y	F	A	L	Y	A	L	Q	F	F	L	P	Q	L	V	A	S	L	A	H	G	T	A	T	L	T	A	A	T	L	A	A	L	P	Y	G	V	A	A	L	A	M	L	A	W	S	H	R	S	I
Secondary structure
SS confidence
Disorder																													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	R	S	G	A	Q	A	G	H	I	T	L	P	T	T	A	A	G	S	A	A	L	G	A	A	L	S	P	M	S	P	I	V	T	L	S	W	L	T	I	A	V	A	G	I	L	A	A	M	P	A	F	W	S	R	C	T	A	A	L
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	G	P	R	V	A	V	A	I	A	T	V	N	A	V	A	S	L	A	S	F	A	G	P	Y	A	T	G	H	L	K	D	A	T	G	T	Y	H	L	A	L	L	T	V	A	A	V	L	A	A	A	A	A	C	S	L	L	L	R	H
Secondary structure
SS confidence
Disorder		?	?	?																																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.
Sequence		A	G	R	T	V	C	A	N	D	S	E	I	M	L	H	P	S	P	A	T	P	F	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 1pw4 chain A Region: 2 - 433 Aligned: 420 Modelled: 432 Confidence: 100.0% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6e9o chain A Region: 14 - 424 Aligned: 391 Modelled: 399 Confidence: 100.0% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4cl5 chain B Region: 9 - 428 Aligned: 420 Modelled: 420 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 4lds chain B Region: 20 - 423 Aligned: 403 Modelled: 404 Confidence: 100.0% Identity: 12% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 6h7d chain A Region: 13 - 438 Aligned: 425 Modelled: 426 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 4iu8 chain A Region: 5 - 418 Aligned: 412 Modelled: 413 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 4j05 chain A Region: 17 - 435 Aligned: 408 Modelled: 419 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 6g9x chain B Region: 18 - 424 Aligned: 368 Modelled: 379 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 3wdo chain A Region: 10 - 437 Aligned: 404 Modelled: 413 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 5c65 chain A Region: 12 - 437 Aligned: 425 Modelled: 426 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 4zp0 chain A Region: 11 - 419 Aligned: 392 Modelled: 403 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 4gbz chain A Region: 14 - 435 Aligned: 422 Modelled: 422 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:d-xylose-proton symporter; PDBTitle: the structure of the mfs (major facilitator superfamily) proton:xylose2 symporter xyle bound to d-glucose Phyre2 PDB 1pv7 chain A Region: 13 - 434 Aligned: 413 Modelled: 422 Confidence: 100.0% Identity: 9% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 13 - 434 Aligned: 413 Modelled: 422 Confidence: 100.0% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 4ybq chain B Region: 11 - 439 Aligned: 428 Modelled: 429 Confidence: 100.0% Identity: 12% PDB header:transport protein/immune system Chain: B: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: rat glut5 with fv in the outward-open form Phyre2 PDB 3o7p chain A Region: 23 - 421 Aligned: 397 Modelled: 399 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4iu9 chain A Region: 10 - 419 Aligned: 382 Modelled: 382 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter Phyre2 PDB 6exs chain A Region: 3 - 424 Aligned: 420 Modelled: 422 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 2gfp chain A Region: 20 - 418 Aligned: 375 Modelled: 378 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 4aps chain B Region: 15 - 418 Aligned: 396 Modelled: 404 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 1 d1pw4a_ 2 c6e9oA_ 3 c4cl5B_ 4 c4ldsB_ 5 c6h7dA_ 6 c4iu8A_ 7 c4j05A_ 8 c6g9xB_ 9 c3wdoA_ 10 c5c65A_ 11 c4zp0A_ 12 c4gbzA_ 13 d1pv7a_ 14 c1pv7B_ 15 c4ybqB_ 16 c3o7pA_ 17 c4iu9A_ 18 c6exsA_ 19 c2gfpA_ 20 c4apsB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50