1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	L	L	V	P	I	L	I	I	T	L	M	Y	F	M	F	E	N	V	P	H	R	P	G	T	P	S	G	F	N	T	A	C	L	V	L	L	G	L	F	P	L	F	V	M	F	V	I	T	A	I	T	M	Q	R	E	R	A	S
Secondary structure
SS confidence
Disorder		?	?															?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	T	L	E	R	I	L	T	T	P	L	R	R	L	D	L	L	A	G	Y	G	T	A	F	S	I	A	A	A	A	Q	A	T	L	A	C	I	V	A	F	W	F	L	G	F	D	T	A	G	S	P	V	W	V	F	A	I	A	I	V
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	A	V	L	G	V	G	L	G	L	L	C	S	A	F	A	R	T	E	F	Q	A	V	Q	F	I	P	L	V	M	V	P	Q	L	L	L	A	G	I	I	V	P	R	A	L	M	P	T	W	L	E	W	I	S	N	V	M	P	A	S
Secondary structure
SS confidence
Disorder																	?	?	?																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
Sequence		Y	A	L	E	A	L	Q	Q	V	G	A	H	P	E	L	T	G	I	A	V	R	D	V	V	V	V	L	S	F	A	V	A	S	L	C	L	A	A	V	T	L	R	R	R	T	S
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 87%) Beta strand ( 0%) TM helix ( 64%) (View membrane topology prediction)

Rank Aligned region

PDB 6an7 chain C Region: 2 - 225 Aligned: 217 Modelled: 224 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: C: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 6an7 chain D Region: 2 - 225 Aligned: 215 Modelled: 224 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: D: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5do7 chain B Region: 3 - 225 Aligned: 220 Modelled: 220 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5do7 chain A Region: 3 - 224 Aligned: 222 Modelled: 222 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family g member 5; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5njg chain B Region: 3 - 225 Aligned: 220 Modelled: 223 Confidence: 99.9% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 5nj3 chain B Region: 2 - 225 Aligned: 224 Modelled: 224 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: complete structure Phyre2 PDB 5xjy chain A Region: 37 - 220 Aligned: 183 Modelled: 184 Confidence: 99.3% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family a member 1; PDBTitle: cryo-em structure of human abca1 Phyre2 PDB 5lj7 chain B Region: 30 - 142 Aligned: 113 Modelled: 113 Confidence: 47.8% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of aggregatibacter actinomycetemcomitans macb bound to atp2 (p21) Phyre2 PDB 5n9y chain B Region: 168 - 225 Aligned: 58 Modelled: 58 Confidence: 28.6% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:zinc transport protein zntb; PDBTitle: the full-length structure of zntb Phyre2 PDB 5nik chain K Region: 30 - 143 Aligned: 114 Modelled: 114 Confidence: 21.1% Identity: 12% PDB header:transport protein Chain: K: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of the macab-tolc abc-type tripartite multidrug efflux pump Phyre2 PDB 2hqw chain B Region: 221 - 226 Aligned: 6 Modelled: 6 Confidence: 12.0% Identity: 50% PDB header:metal binding protein Chain: B: PDB Molecule:glutamate nmda receptor subunit zeta 1; PDBTitle: crystal structure of ca2+/calmodulin bound to nmda receptor nr1c12 peptide Phyre2 PDB 3rko chain F Region: 72 - 226 Aligned: 150 Modelled: 155 Confidence: 10.0% Identity: 15% PDB header:oxidoreductase Chain: F: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: crystal structure of the membrane domain of respiratory complex i from2 e. coli at 3.0 angstrom resolution Phyre2 PDB 2bbj chain B Region: 205 - 225 Aligned: 21 Modelled: 21 Confidence: 9.8% Identity: 19% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 2na6 chain C Region: 203 - 226 Aligned: 24 Modelled: 24 Confidence: 9.1% Identity: 17% PDB header:apoptosis Chain: C: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain B Region: 203 - 226 Aligned: 24 Modelled: 24 Confidence: 9.1% Identity: 17% PDB header:apoptosis Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain A Region: 203 - 226 Aligned: 24 Modelled: 24 Confidence: 9.1% Identity: 17% PDB header:apoptosis Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 4fz1 chain D Region: 221 - 226 Aligned: 6 Modelled: 6 Confidence: 7.7% Identity: 50% PDB header:transport protein Chain: D: PDB Molecule:pi-theraphotoxin-pc1a; PDBTitle: crystal structure of acid-sensing ion channel in complex with2 psalmotoxin 1 at high ph Phyre2 PDB 2iub chain A domain 2 Region: 137 - 225 Aligned: 48 Modelled: 57 Confidence: 7.3% Identity: 29% Fold: Transmembrane helix hairpin Superfamily: Magnesium transport protein CorA, transmembrane region Family: Magnesium transport protein CorA, transmembrane region Phyre2 PDB 1lmm chain A Region: 221 - 226 Aligned: 6 Modelled: 6 Confidence: 6.7% Identity: 50% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 6cfw chain G Region: 192 - 226 Aligned: 35 Modelled: 35 Confidence: 6.3% Identity: 11% PDB header:membrane protein Chain: G: PDB Molecule:monovalent cation/h+ antiporter subunit c; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 1 c6an7C_ 2 c6an7D_ 3 c5do7B_ 4 c5do7A_ 5 c5njgB_ 6 c5nj3B_ 7 c5xjyA_ 8 c5lj7B_ 9 c5n9yB_ 10 c5nikK_ 11 c2hqwB_ 12 c3rkoF_ 13 c2bbjB_ 14 c2na6C_ 15 c2na6B_ 16 c2na6A_ 17 c4fz1D_ 18 d2iuba2 19 d1lmma_ 20 c6cfwG_