1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	M	I	L	D	E	L	S	W	R	G	L	I	A	Q	S	T	D	L	D	T	L	A	A	E	A	Q	R	G	P	M	T	V	Y	A	G	F	D	P	T	A	P	S	L	H	A	G	H	L	V	P	L	L	T	L	R	R	F
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	R	A	G	H	R	P	I	V	L	A	G	G	A	T	G	M	I	G	D	P	R	D	V	G	E	R	S	L	N	E	A	D	T	V	A	E	W	T	E	R	I	R	G	Q	L	E	R	F	V	D	F	D	D	S	P	M	G	A	I
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	E	N	N	L	E	W	T	G	S	L	S	A	I	E	F	L	R	D	I	G	K	H	F	S	V	N	V	M	L	A	R	D	T	I	R	R	R	L	A	G	E	G	I	S	Y	T	E	F	S	Y	L	L	L	Q	A	N	D	Y	V
Secondary structure
SS confidence
Disorder																															?	?	?						?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	L	H	R	R	H	G	C	T	L	Q	I	G	G	A	D	Q	W	G	N	I	I	A	G	V	R	L	V	R	Q	K	L	G	A	T	V	H	A	L	T	V	P	L	V	T	A	A	D	G	T	K	F	G	K	S	T	G	G	G	S
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	W	L	D	P	Q	M	T	S	P	Y	A	W	Y	Q	Y	F	V	N	T	A	D	A	D	V	I	R	Y	L	R	W	F	T	F	L	S	A	D	E	L	A	E	L	E	Q	A	T	A	Q	R	P	Q	Q	R	A	A	Q	R	R	L
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	S	E	L	T	V	L	V	H	G	E	A	A	T	A	A	V	E	H	A	S	R	A	L	F	G	R	G	E	L	A	R	L	D	E	A	T	L	A	A	A	L	R	E	T	T	V	A	E	L	K	P	G	S	P	D	G	I	V	D
Secondary structure
SS confidence
Disorder																											?		?	?	?	?	?	?	?								?	?	?			?		?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	L	V	A	S	G	L	S	A	S	K	G	A	A	R	R	T	I	H	E	G	G	V	S	V	N	N	I	R	V	D	N	E	E	W	V	P	Q	S	S	D	F	L	H	G	R	W	L	V	L	R	R	G	K	R	S	I	A	G	V
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?												?																				?
Disorder confidence
		.	.	.	.
Sequence		E	R	I	G
Secondary structure
SS confidence
Disorder				?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 51%) Beta strand ( 13%)

Rank Aligned region

PDB 2jan chain D Region: 5 - 424 Aligned: 407 Modelled: 420 Confidence: 100.0% Identity: 100% PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state Phyre2 PDB 6otj chain A Region: 4 - 422 Aligned: 415 Modelled: 419 Confidence: 100.0% Identity: 46% PDB header:ligase Chain: A: PDB Molecule:tyrosine--trna ligase; PDBTitle: crystal structure of tyrosyl-trna synthetase from neisseria2 gonorrhoeae with bound l-tyr Phyre2 PDB 4oud chain A Region: 3 - 422 Aligned: 406 Modelled: 420 Confidence: 100.0% Identity: 44% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: engineered tyrosyl-trna synthetase with the nonstandard amino acid l-2 4,4-biphenylalanine Phyre2 PDB 1h3e chain A Region: 2 - 422 Aligned: 405 Modelled: 421 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed with wild-2 type trnatyr(gua) and with atp and tyrosinol Phyre2 PDB 4oud chain B Region: 4 - 422 Aligned: 356 Modelled: 369 Confidence: 100.0% Identity: 46% PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: engineered tyrosyl-trna synthetase with the nonstandard amino acid l-2 4,4-biphenylalanine Phyre2 PDB 6n0w chain A Region: 3 - 338 Aligned: 321 Modelled: 336 Confidence: 100.0% Identity: 45% PDB header:ligase Chain: A: PDB Molecule:tyrosine--trna ligase; PDBTitle: crystal structure of a tyrosine--trna ligase from elizabethkingia2 anophelis Phyre2 PDB 2rkj chain M Region: 1 - 324 Aligned: 323 Modelled: 324 Confidence: 100.0% Identity: 35% PDB header:ligase/rna Chain: M: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing factor with2 a group i intron rna Phyre2 PDB 5ijx chain A Region: 1 - 321 Aligned: 312 Modelled: 321 Confidence: 100.0% Identity: 35% PDB header:ligase Chain: A: PDB Molecule:tyrosine--trna ligase, mitochondrial; PDBTitle: crystal structure of a c-terminally truncated coccidioides posadasii2 mitochondrial tyrosyl-trna synthetase Phyre2 PDB 2pid chain B Region: 5 - 324 Aligned: 306 Modelled: 320 Confidence: 100.0% Identity: 40% PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog Phyre2 PDB 5ihx chain B Region: 3 - 325 Aligned: 315 Modelled: 315 Confidence: 100.0% Identity: 35% PDB header:ligase Chain: B: PDB Molecule:tyrosine--trna ligase, mitochondrial; PDBTitle: crystal structure of a c-terminally truncated aspergillus nidulans2 mitochondrial tyrosyl-trna synthetase Phyre2 PDB 1jil chain A Region: 2 - 325 Aligned: 321 Modelled: 324 Confidence: 100.0% Identity: 49% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1x8x chain A Region: 2 - 319 Aligned: 317 Modelled: 318 Confidence: 100.0% Identity: 53% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine Phyre2 PDB 1jii chain A Region: 2 - 321 Aligned: 317 Modelled: 319 Confidence: 100.0% Identity: 49% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383 Phyre2 PDB 2ts1 chain A Region: 4 - 321 Aligned: 315 Modelled: 318 Confidence: 100.0% Identity: 55% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2ts1 chain A Region: 4 - 321 Aligned: 315 Modelled: 318 Confidence: 100.0% Identity: 55% PDB header:ligase (synthetase) Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate Phyre2 PDB 1h3f chain A domain 1 Region: 8 - 325 Aligned: 283 Modelled: 293 Confidence: 100.0% Identity: 29% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 6byq chain A Region: 1 - 319 Aligned: 300 Modelled: 319 Confidence: 100.0% Identity: 28% PDB header:ligase Chain: A: PDB Molecule:tyrosine--trna ligase; PDBTitle: crystal structure of tyrosine-trna ligase from helicobacter pylori g27 Phyre2 PDB 2cyb chain A Region: 8 - 308 Aligned: 280 Modelled: 296 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus Phyre2 PDB 3tze chain A Region: 9 - 317 Aligned: 287 Modelled: 309 Confidence: 100.0% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of a tryptophanyl-trna synthetase from2 encephalitozoon cuniculi bound to tryptophan Phyre2 PDB 2qui chain B Region: 9 - 331 Aligned: 303 Modelled: 323 Confidence: 100.0% Identity: 17% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp Phyre2 1 c2janD_ 2 c6otjA_ 3 c4oudA_ 4 c1h3eA_ 5 c4oudB_ 6 c6n0wA_ 7 c2rkjM_ 8 c5ijxA_ 9 c2pidB_ 10 c5ihxB_ 11 d1jila_ 12 c1x8xA_ 13 c1jiiA_ 14 d2ts1a_ 15 c2ts1A_ 16 d1h3fa1 17 c6byqA_ 18 c2cybA_ 19 c3tzeA_ 20 c2quiB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217