1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	S	I	A	Q	E	H	D	C	L	L	I	D	L	D	G	T	V	F	C	G	R	Q	P	T	G	G	A	V	Q	S	L	S	Q	V	R	S	R	K	L	F	V	T	N	N	A	S	R	S	A	D	E	V	A	A	H	L	C	E
Secondary structure
SS confidence
Disorder		?	?	?																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	G	F	T	A	T	G	E	D	V	V	T	S	A	Q	S	A	A	H	L	L	A	G	Q	L	A	P	G	A	R	V	L	I	V	G	T	E	A	L	A	N	E	V	A	A	V	G	L	R	P	V	R	R	F	E	D	R	P	D	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	Q	G	L	S	M	T	T	G	W	S	D	L	A	E	A	A	L	A	I	R	A	G	A	L	W	V	A	A	N	V	D	P	T	L	P	T	E	R	G	L	L	P	G	N	G	S	M	V	A	A	L	R	T	A	T	G	M	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	R	V	A	G	K	P	A	P	A	L	M	T	E	A	V	A	R	G	D	F	R	A	A	L	V	V	G	D	R	L	D	T	D	I	E	G	A	N	A	A	G	L	P	S	L	M	V	L	T	G	V	N	S	A	W	D	A	V	Y
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	E	P	V	R	R	P	T	Y	I	G	H	D	L	R	S	L	H	Q	D	S	K	L	L	A	V	A	P	Q	P	G	W	Q	I	D	V	G	G	G	A	V	T	V	C	A	N	G	D	V	D	D	L	E	F	I	D	D	G	L	S
Secondary structure
SS confidence
Disorder		?	?	?																		?		?	?	?	?	?	?	?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.
Sequence		I	V	R	A	V	A	S	A	V	W	E	A	R	A	A	D	L	H	Q	R	P	L	R	I	E	A	G	D	E	R	A	R	A	A	L	Q	R	W	S	L	M	R	S	D	H	P	V	T	S	V	G	T	Q
Secondary structure
SS confidence
Disorder																				?					?	?	?	?	?														?					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 38%) Beta strand ( 18%)

Rank Aligned region

PDB 4i9g chain B Region: 1 - 341 Aligned: 326 Modelled: 341 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: B: PDB Molecule:glycerol 3-phosphate phosphatase; PDBTitle: crystal structure of glycerol phosphate phosphatase rv1692 from2 mycobacterium tuberculosis in complex with magnesium Phyre2 PDB 3kc2 chain A Region: 10 - 256 Aligned: 240 Modelled: 247 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ykr070w; PDBTitle: crystal structure of mitochondrial had-like phosphatase from2 saccharomyces cerevisiae Phyre2 PDB 2ho4 chain A Region: 9 - 259 Aligned: 239 Modelled: 251 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:haloacid dehalogenase-like hydrolase domain containing 2; PDBTitle: crystal structure of protein from mouse mm.236127 Phyre2 PDB 4ig4 chain A Region: 6 - 257 Aligned: 246 Modelled: 252 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:thermostable nppase; PDBTitle: crystal structure of single mutant thermostable nppase (n86s) from2 geobacillus stearothermophilus Phyre2 PDB 1wvi chain A Region: 7 - 257 Aligned: 246 Modelled: 251 Confidence: 100.0% Identity: 30% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 1ydf chain A domain 1 Region: 8 - 257 Aligned: 245 Modelled: 247 Confidence: 100.0% Identity: 33% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 3qgm chain C Region: 7 - 259 Aligned: 250 Modelled: 250 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: C: PDB Molecule:p-nitrophenyl phosphatase (pho2); PDBTitle: p-nitrophenyl phosphatase from archaeoglobus fulgidus Phyre2 PDB 1ys9 chain A domain 1 Region: 8 - 257 Aligned: 245 Modelled: 250 Confidence: 100.0% Identity: 29% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 2cft chain A Region: 1 - 259 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 33% PDB header:phosphatase Chain: A: PDB Molecule:pyridoxal phosphate phosphatase; PDBTitle: crystal structure of human pyridoxal 5'-phosphate2 phosphatase with its substrate Phyre2 PDB 1yv9 chain A domain 1 Region: 7 - 257 Aligned: 246 Modelled: 251 Confidence: 100.0% Identity: 33% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 1zjj chain A Region: 9 - 259 Aligned: 248 Modelled: 251 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein ph1952; PDBTitle: crystal structure of hypothetical protein ph1952 from pyrococcus2 horikoshii ot3 Phyre2 PDB 2c4n chain A domain 1 Region: 7 - 259 Aligned: 243 Modelled: 253 Confidence: 100.0% Identity: 27% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 3pdw chain A Region: 6 - 259 Aligned: 242 Modelled: 254 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized hydrolase yutf; PDBTitle: crystal structure of putative p-nitrophenyl phosphatase from bacillus2 subtilis Phyre2 PDB 1vjr chain A Region: 4 - 259 Aligned: 250 Modelled: 256 Confidence: 100.0% Identity: 28% Fold: HAD-like Superfamily: HAD-like Family: NagD-like Phyre2 PDB 2x4d chain A Region: 5 - 259 Aligned: 244 Modelled: 250 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:phospholysine phosphohistidine inorganic pyrophosphate PDBTitle: crystal structure of human phospholysine phosphohistidine inorganic2 pyrophosphate phosphatase lhpp Phyre2 PDB 2hx1 chain D Region: 2 - 253 Aligned: 252 Modelled: 252 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: D: PDB Molecule:predicted sugar phosphatases of the had superfamily; PDBTitle: crystal structure of possible sugar phosphatase, had superfamily2 (zp_00311070.1) from cytophaga hutchinsonii atcc 33406 at 2.10 a3 resolution Phyre2 PDB 2x4d chain B Region: 12 - 256 Aligned: 209 Modelled: 242 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:phospholysine phosphohistidine inorganic pyrophosphate PDBTitle: crystal structure of human phospholysine phosphohistidine inorganic2 pyrophosphate phosphatase lhpp Phyre2 PDB 2fdr chain A domain 1 Region: 8 - 259 Aligned: 212 Modelled: 214 Confidence: 99.9% Identity: 17% Fold: HAD-like Superfamily: HAD-like Family: beta-Phosphoglucomutase-like Phyre2 PDB 3iru chain A Region: 9 - 259 Aligned: 205 Modelled: 228 Confidence: 99.9% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:phoshonoacetaldehyde hydrolase like protein; PDBTitle: crystal structure of phoshonoacetaldehyde hydrolase like protein from2 oleispira antarctica Phyre2 PDB 3d6j chain A Region: 7 - 257 Aligned: 204 Modelled: 212 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative haloacid dehalogenase-like hydrolase; PDBTitle: crystal structure of putative haloacid dehalogenase-like hydrolase2 from bacteroides fragilis Phyre2 1 c4i9gB_ 2 c3kc2A_ 3 c2ho4A_ 4 c4ig4A_ 5 d1wvia_ 6 d1ydfa1 7 c3qgmC_ 8 d1ys9a1 9 c2cftA_ 10 d1yv9a1 11 c1zjjA_ 12 d2c4na1 13 c3pdwA_ 14 d1vjra_ 15 c2x4dA_ 16 c2hx1D_ 17 c2x4dB_ 18 d2fdra1 19 c3iruA_ 20 c3d6jA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214