1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	E	H	D	F	E	T	I	S	S	E	T	L	H	T	G	A	I	F	A	L	R	R	D	Q	V	R	M	P	G	G	G	I	V	T	R	E	V	V	E	H	F	G	A	V	A	I	V	A	M	D	D	N	G	N	I	P	M	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	Q	Y	R	H	T	Y	G	R	R	L	W	E	L	P	A	G	L	L	D	V	A	G	E	P	P	H	L	T	A	A	R	E	L	R	E	E	V	G	L	Q	A	S	T	W	Q	V	L	V	D	L	D	T	A	P	G	F	S	D	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	V	R	V	Y	L	A	T	G	L	R	E	V	G	R	P	E	A	H	H	E	E	A	D	M	T	M	G	W	Y	P	I	A	E	A	A	R	R	V	L	R	G	E	I	V	N	S	I	A	I	A	G	V	L	A	V	H	A	V	T
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.
Sequence		T	G	F	A	Q	P	R	P	L	D	T	E	W	I	D	R	P	T	A	F	A	A	R	R	A	E	R
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 17%) Beta strand ( 42%)

Rank Aligned region

PDB 1mqe chain A Region: 6 - 207 Aligned: 187 Modelled: 202 Confidence: 100.0% Identity: 97% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5c7t chain B Region: 5 - 184 Aligned: 177 Modelled: 180 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:nudf protein; PDBTitle: crystal structure of the bdellovibrio bacteriovorus nucleoside2 diphosphate sugar hydrolase in complex with adp-ribose Phyre2 PDB 1vhz chain A Region: 2 - 185 Aligned: 181 Modelled: 184 Confidence: 100.0% Identity: 18% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 1g0s chain A Region: 1 - 185 Aligned: 178 Modelled: 179 Confidence: 100.0% Identity: 24% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2yvo chain A Region: 4 - 181 Aligned: 175 Modelled: 178 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of ndx2 in complex with mg2+ and amp from thermus2 thermophilus hb8 Phyre2 PDB 1viu chain A Region: 4 - 177 Aligned: 163 Modelled: 174 Confidence: 100.0% Identity: 23% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3bm4 chain B Region: 7 - 186 Aligned: 179 Modelled: 180 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:adp-sugar pyrophosphatase; PDBTitle: crystal structure of human adp-ribose pyrophosphatase nudt5 in complex2 with magnesium and ampcpr Phyre2 PDB 1v8y chain A Region: 11 - 181 Aligned: 149 Modelled: 161 Confidence: 100.0% Identity: 38% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2w4e chain A Region: 41 - 181 Aligned: 130 Modelled: 131 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: structure of an n-terminally truncated nudix hydrolase2 dr2204 from deinococcus radiodurans Phyre2 PDB 3q91 chain D Region: 42 - 178 Aligned: 128 Modelled: 128 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:uridine diphosphate glucose pyrophosphatase; PDBTitle: crystal structure of human uridine diphosphate glucose pyrophosphatase2 (nudt14) Phyre2 PDB 1sjy chain A Region: 45 - 187 Aligned: 141 Modelled: 143 Confidence: 99.9% Identity: 18% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 6o3p chain A Region: 44 - 175 Aligned: 124 Modelled: 132 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:peroxisomal nadh pyrophosphatase nudt12; PDBTitle: crystal structure of the catalytic domain of mouse nudt12 in complex2 with amp and 3 mg2+ ions Phyre2 PDB 5gg7 chain A Region: 45 - 207 Aligned: 152 Modelled: 163 Confidence: 99.9% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 3fjy chain B Region: 53 - 207 Aligned: 148 Modelled: 152 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:probable mutt1 protein; PDBTitle: crystal structure of a probable mutt1 protein from bifidobacterium2 adolescentis Phyre2 PDB 2fkb chain A domain 1 Region: 45 - 179 Aligned: 128 Modelled: 132 Confidence: 99.8% Identity: 17% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 1vk6 chain A domain 2 Region: 42 - 155 Aligned: 106 Modelled: 114 Confidence: 99.8% Identity: 20% Fold: Nudix Superfamily: Nudix Family: NADH pyrophosphatase Phyre2 PDB 2o5f chain A domain 1 Region: 45 - 176 Aligned: 124 Modelled: 132 Confidence: 99.8% Identity: 15% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 2b0v chain A domain 1 Region: 42 - 158 Aligned: 115 Modelled: 117 Confidence: 99.8% Identity: 15% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5lop chain A Region: 44 - 164 Aligned: 115 Modelled: 121 Confidence: 99.8% Identity: 15% PDB header:rna binding protein Chain: A: PDB Molecule:klla0f23980p; PDBTitle: structure of the active form of /k. lactis/ dcp1-dcp2-edc3 decapping2 complex bound to m7gdp Phyre2 PDB 2jvb chain A Region: 44 - 190 Aligned: 141 Modelled: 146 Confidence: 99.8% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:mrna-decapping enzyme subunit 2; PDBTitle: solution structure of catalytic domain of ydcp2 Phyre2 1 d1mqea_ 2 c5c7tB_ 3 d1vhza_ 4 d1g0sa_ 5 c2yvoA_ 6 d1viua_ 7 c3bm4B_ 8 d1v8ya_ 9 c2w4eA_ 10 c3q91D_ 11 d1sjya_ 12 c6o3pA_ 13 c5gg7A_ 14 c3fjyB_ 15 d2fkba1 16 d1vk6a2 17 d2o5fa1 18 d2b0va1 19 c5lopA_ 20 c2jvbA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116