1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	G	L	Q	N	S	L	A	N	G	G	T	A	P	E	N	G	Y	S	A	G	F	R	V	R	L	T	N	F	E	G	P	F	D	L	L	L	Q	L	I	F	A	H	Q	L	D	V	T	E	V	A	L	H	Q	V	T	D	D	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	A	Y	T	K	A	I	G	A	R	L	E	L	E	E	T	T	A	F	L	V	I	A	A	T	L	L	D	L	K	A	A	R	L	L	P	A	G	Q	V	D	D	E	E	D	L	A	L	L	E	V	R	D	L	L	F	A	R	L	L
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	Y	R	A	F	K	H	V	A	E	M	F	A	E	L	E	A	T	A	L	R	S	Y	P	R	A	V	S	L	E	D	G	F	V	G	L	L	P	E	V	M	L	G	V	D	A	H	R	F	A	E	I	A	A	I	A	L	T	P	R
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?		?			?	?	?	?	?	?	?	?	?		?	?	?	?	?															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	A	P	T	V	A	T	E	H	L	H	E	L	M	V	S	V	P	E	Q	A	E	H	L	L	A	M	L	K	A	R	G	S	G	Q	W	A	S	F	S	E	L	V	A	D	C	T	A	P	I	E	I	V	G	R	F	L	A	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?																							?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.
Sequence		E	L	Y	R	T	R	A	V	A	F	E	Q	S	E	P	L	G	A	L	Q	V	S	W	T	G	D	D	A	E	R	S	D	E	K	E	R	R	L
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 53%) Beta strand ( 8%)

Rank Aligned region

PDB 4i98 chain A Region: 28 - 183 Aligned: 146 Modelled: 156 Confidence: 100.0% Identity: 25% PDB header:cell cycle Chain: A: PDB Molecule:segregation and condensation protein a; PDBTitle: crystal structure of the complex between scpa(residues 1-160)-2 scpb(residues 1-183) Phyre2 PDB 3w6j chain A Region: 22 - 185 Aligned: 144 Modelled: 164 Confidence: 100.0% Identity: 32% PDB header:cell cycle Chain: A: PDB Molecule:scpa; PDBTitle: crystal structure of scpab core complex Phyre2 PDB 3zgx chain Z Region: 29 - 96 Aligned: 67 Modelled: 68 Confidence: 99.9% Identity: 40% PDB header:cell cycle Chain: Z: PDB Molecule:segregation and condensation protein a; PDBTitle: crystal structure of the kleisin-n smc interface in2 prokaryotic condensin Phyre2 PDB 5h67 chain C Region: 196 - 265 Aligned: 67 Modelled: 70 Confidence: 99.5% Identity: 25% PDB header:dna binding protein/cell cycle Chain: C: PDB Molecule:segregation and condensation protein a; PDBTitle: crystal structure of the bacillus subtilis smc head domain complexed2 with the cognate scpa c-terminal domain and soaked atp Phyre2 PDB 1w1w chain F Region: 196 - 264 Aligned: 65 Modelled: 69 Confidence: 98.6% Identity: 18% PDB header:cell adhesion Chain: F: PDB Molecule:sister chromatid cohesion protein 1; PDBTitle: sc smc1hd:scc1-c complex, atpgs Phyre2 PDB 1w1w chain E Region: 196 - 264 Aligned: 65 Modelled: 69 Confidence: 98.6% Identity: 18% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Rad21/Rec8-like Phyre2 PDB 4i99 chain C Region: 196 - 261 Aligned: 65 Modelled: 66 Confidence: 98.3% Identity: 32% PDB header:dna binding protein Chain: C: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the smchead bound to the c-winged helix domain of2 scpa Phyre2 PDB 6qj4 chain E Region: 234 - 263 Aligned: 30 Modelled: 30 Confidence: 86.6% Identity: 23% PDB header:cell cycle Chain: E: PDB Molecule:condensin complex subunit 2; PDBTitle: crystal structure of the c. thermophilum condensin ycs4-brn12 subcomplex bound to the smc4 atpase head in complex with the c-3 terminal domain of brn1 Phyre2 PDB 2l01 chain A Region: 196 - 267 Aligned: 65 Modelled: 70 Confidence: 84.1% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of protein bvu3908 from bacteroides vulgatus,2 northeast structural genomics consortium target bvr153 Phyre2 PDB 2l02 chain B Region: 196 - 262 Aligned: 60 Modelled: 67 Confidence: 62.8% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of protein bt2368 from bacteroides2 thetaiotaomicron, northeast structural genomics consortium target3 btr375 Phyre2 PDB 3f41 chain B Region: 190 - 248 Aligned: 54 Modelled: 59 Confidence: 57.5% Identity: 7% PDB header:hydrolase Chain: B: PDB Molecule:phytase; PDBTitle: structure of the tandemly repeated protein tyrosine2 phosphatase like phytase from mitsuokella multacida Phyre2 PDB 1whq chain A Region: 35 - 52 Aligned: 18 Modelled: 18 Confidence: 34.5% Identity: 22% Fold: dsRBD-like Superfamily: dsRNA-binding domain-like Family: Double-stranded RNA-binding domain (dsRBD) Phyre2 PDB 2qdo chain C Region: 61 - 94 Aligned: 34 Modelled: 34 Confidence: 20.9% Identity: 21% PDB header:photosynthesis Chain: C: PDB Molecule:nbla protein; PDBTitle: nbla protein from t. vulcanus Phyre2 PDB 1u24 chain A Region: 190 - 248 Aligned: 54 Modelled: 59 Confidence: 19.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:myo-inositol hexaphosphate phosphohydrolase; PDBTitle: crystal structure of selenomonas ruminantium phytase Phyre2 PDB 2bbr chain A Region: 26 - 55 Aligned: 30 Modelled: 30 Confidence: 19.9% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:viral casp8 and fadd-like apoptosis regulator; PDBTitle: crystal structure of mc159 reveals molecular mechanism of2 disc assembly and vflip inhibition Phyre2 PDB 2gf5 chain A domain 2 Region: 26 - 55 Aligned: 30 Modelled: 30 Confidence: 18.8% Identity: 20% Fold: DEATH domain Superfamily: DEATH domain Family: DEATH effector domain, DED Phyre2 PDB 2bbz chain C Region: 26 - 55 Aligned: 30 Modelled: 30 Confidence: 18.1% Identity: 17% PDB header:viral protein Chain: C: PDB Molecule:viral casp8 and fadd-like apoptosis regulator; PDBTitle: crystal structure of mc159 reveals molecular mechanism of2 disc assembly and vflip inhibition Phyre2 PDB 2ls7 chain A Region: 26 - 55 Aligned: 30 Modelled: 30 Confidence: 16.8% Identity: 10% PDB header:apoptosis Chain: A: PDB Molecule:astrocytic phosphoprotein pea-15; PDBTitle: high definition solution structure of ped/pea-15 death effector domain Phyre2 PDB 1ock chain A Region: 33 - 72 Aligned: 35 Modelled: 40 Confidence: 14.3% Identity: 17% Fold: Amidase signature (AS) enzymes Superfamily: Amidase signature (AS) enzymes Family: Amidase signature (AS) enzymes Phyre2 PDB 2ixm chain A domain 1 Region: 37 - 87 Aligned: 51 Modelled: 51 Confidence: 13.8% Identity: 18% Fold: PTPA-like Superfamily: PTPA-like Family: PTPA-like Phyre2 1 c4i98A_ 2 c3w6jA_ 3 c3zgxZ_ 4 c5h67C_ 5 c1w1wF_ 6 d1w1we_ 7 c4i99C_ 8 c6qj4E_ 9 c2l01A_ 10 c2l02B_ 11 c3f41B_ 12 d1whqa_ 13 c2qdoC_ 14 c1u24A_ 15 c2bbrA_ 16 d2gf5a2 17 c2bbzC_ 18 c2ls7A_ 19 d1ocka_ 20 d2ixma1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67