1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	L	T	R	A	S	Q	A	P	R	Y	V	A	P	A	H	H	E	V	S	T	M	R	L	Q	G	R	E	A	G	R	T	E	R	F	W	V	G	L	S	V	Y	R	P	G	G	T	A	E	P	A	P	T	R	E	E	T	V	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?																		?	?	?	?	?		?														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.
Sequence		V	V	L	D	G	E	L	V	V	T	V	D	G	A	E	T	V	L	G	W	L	D	S	V	H	L	A	K	G	E	L	R	S	I	H	N	R	T	D	R	Q	A	L	L	L	V	T	V	A	H	P	V	A	E	V	A
Secondary structure
SS confidence
Disorder																																																				?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 5%) Beta strand ( 50%)

Rank Aligned region

PDB 5tg0 chain A Region: 1 - 112 Aligned: 112 Modelled: 112 Confidence: 99.9% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:dimethylsulfoniopropionate lyase dddk; PDBTitle: crystal structure of the dimethylsulfoniopropionate (dmsp) lyase dddk2 complexed with iron and zinc Phyre2 PDB 1lr5 chain A Region: 1 - 115 Aligned: 114 Modelled: 115 Confidence: 99.9% Identity: 18% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: Germin/Seed storage 7S protein Phyre2 PDB 1vj2 chain A Region: 1 - 114 Aligned: 114 Modelled: 114 Confidence: 99.8% Identity: 19% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: TM1459-like Phyre2 PDB 3ht2 chain A Region: 2 - 115 Aligned: 114 Modelled: 114 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:remf protein; PDBTitle: zink containing polyketide cyclase remf from streptomyces2 resistomycificus Phyre2 PDB 1o4t chain A Region: 3 - 108 Aligned: 106 Modelled: 106 Confidence: 99.8% Identity: 22% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: TM1287-like Phyre2 PDB 5uqp chain A Region: 12 - 111 Aligned: 100 Modelled: 100 Confidence: 99.8% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:cupin; PDBTitle: the crystal structure of cupin protein from rhodococcus jostii rha1 Phyre2 PDB 3jzv chain A Region: 15 - 112 Aligned: 98 Modelled: 98 Confidence: 99.8% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein rru_a2000; PDBTitle: crystal structure of rru_a2000 from rhodospirillum rubrum: a cupin-22 domain. Phyre2 PDB 3i7d chain B Region: 31 - 115 Aligned: 85 Modelled: 85 Confidence: 99.8% Identity: 26% PDB header:isomerase Chain: B: PDB Molecule:sugar phosphate isomerase; PDBTitle: crystal structure of sugar phosphate isomerase from a cupin2 superfamily spo2919 from silicibacter pomeroyi (yp_168127.1) from3 silicibacter pomeroyi dss-3 at 2.30 a resolution Phyre2 PDB 2oa2 chain A Region: 33 - 111 Aligned: 79 Modelled: 79 Confidence: 99.8% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:bh2720 protein; PDBTitle: crystal structure of bh2720 (10175341) from bacillus halodurans at2 1.41 a resolution Phyre2 PDB 4i4a chain A Region: 3 - 111 Aligned: 106 Modelled: 108 Confidence: 99.8% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:similar to unknown protein; PDBTitle: crystal structure of plu4264 protein from photorhabdus luminescens Phyre2 PDB 3ibm chain B Region: 17 - 112 Aligned: 96 Modelled: 96 Confidence: 99.8% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:cupin 2, conserved barrel domain protein; PDBTitle: crystal structure of cupin 2 domain-containing protein hhal_0468 from2 halorhodospira halophila Phyre2 PDB 5j7m chain B Region: 19 - 111 Aligned: 93 Modelled: 93 Confidence: 99.8% Identity: 18% PDB header:unknown function Chain: B: PDB Molecule:cupin 2 conserved barrel domain protein; PDBTitle: crystal structure of cupin 2 conserved barrel domain protein from2 kribbella flavida dsm 17836 Phyre2 PDB 4bif chain C Region: 1 - 113 Aligned: 113 Modelled: 113 Confidence: 99.8% Identity: 16% PDB header:lyase Chain: C: PDB Molecule:cupin 2 conserved barrel domain protein; PDBTitle: biochemical and structural characterisation of a novel2 manganese-dependent hydroxynitrile lyase from bacteria Phyre2 PDB 2f4p chain A domain 1 Region: 19 - 113 Aligned: 95 Modelled: 95 Confidence: 99.8% Identity: 12% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: TM1287-like Phyre2 PDB 1sq4 chain A Region: 1 - 108 Aligned: 108 Modelled: 108 Confidence: 99.8% Identity: 14% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: YlbA-like Phyre2 PDB 1v70 chain A Region: 1 - 111 Aligned: 103 Modelled: 111 Confidence: 99.8% Identity: 25% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: TM1287-like Phyre2 PDB 3kgz chain A Region: 8 - 111 Aligned: 104 Modelled: 104 Confidence: 99.8% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:cupin 2 conserved barrel domain protein; PDBTitle: crystal structure of a cupin 2 conserved barrel domain protein from2 rhodopseudomonas palustris Phyre2 PDB 3l2h chain D Region: 3 - 116 Aligned: 113 Modelled: 114 Confidence: 99.8% Identity: 21% PDB header:isomerase Chain: D: PDB Molecule:putative sugar phosphate isomerase; PDBTitle: crystal structure of putative sugar phosphate isomerase (afe_0303)2 from acidithiobacillus ferrooxidans atcc 23270 at 1.85 a resolution Phyre2 PDB 5bxx chain A Region: 1 - 112 Aligned: 107 Modelled: 112 Confidence: 99.8% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:l-ectoine synthase; PDBTitle: crystal structure of the ectoine synthase from the cold-adapted marine2 bacterium sphingopyxis alaskensis Phyre2 PDB 2gu9 chain B Region: 33 - 114 Aligned: 82 Modelled: 82 Confidence: 99.8% Identity: 20% PDB header:immune system Chain: B: PDB Molecule:tetracenomycin polyketide synthesis protein; PDBTitle: crystal structure of xc5357 from xanthomonas campestris: a2 putative tetracenomycin polyketide synthesis protein3 adopting a novel cupin subfamily structure Phyre2 1 c5tg0A_ 2 d1lr5a_ 3 d1vj2a_ 4 c3ht2A_ 5 d1o4ta_ 6 c5uqpA_ 7 c3jzvA_ 8 c3i7dB_ 9 c2oa2A_ 10 c4i4aA_ 11 c3ibmB_ 12 c5j7mB_ 13 c4bifC_ 14 d2f4pa1 15 d1sq4a_ 16 d1v70a_ 17 c3kgzA_ 18 c3l2hD_ 19 c5bxxA_ 20 c2gu9B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350