1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	T	L	T	K	T	L	G	S	L	D	D	F	R	G	T	L	C	V	P	G	D	P	D	Y	P	R	V	R	A	I	W	N	G	Q	V	A	R	E	P	A	L	I	A	T	C	H	D	A	C	D	V	R	T	V	L	R	R
Secondary structure
SS confidence
Disorder		?	?	?								?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	D	A	G	M	V	T	A	V	R	G	G	G	H	N	V	A	G	T	A	L	C	D	G	G	V	V	I	D	L	S	A	M	R	A	V	S	L	D	P	A	T	G	R	V	R	V	Q	G	G	A	T	L	A	D	L	D	H	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	P	F	A	R	V	A	P	A	G	I	V	T	T	T	G	V	G	G	L	T	L	G	G	G	V	G	W	T	T	R	R	F	G	L	S	C	D	N	L	V	A	V	R	L	V	T	A	A	G	D	Y	L	S	V	D	D	E	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	P	E	L	M	W	G	L	R	G	G	G	G	N	F	G	I	V	T	E	F	E	F	A	T	H	P	F	G	P	V	A	V	A	G	F	V	V	Y	R	L	D	D	G	P	A	V	L	R	G	Y	R	Q	F	A	A	A	A	P	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	V	T	T	I	V	V	L	R	H	A	P	P	A	P	W	I	P	V	D	Q	R	G	K	P	V	V	M	I	G	A	V	H	T	G	S	I	Q	T	G	I	E	A	L	R	P	V	K	S	L	A	R	P	V	A	D	T	V	W	P
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?																																		?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	P	F	L	A	H	Q	A	V	L	D	A	S	N	P	A	G	H	R	Y	Y	W	K	S	D	H	L	A	E	L	N	D	E	A	I	D	L	L	V	E	Q	T	A	Q	L	S	S	P	D	S	L	I	G	I	F	Q	L	G	G	A
Secondary structure
SS confidence
Disorder		?																																																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	A	R	G	G	E	R	S	C	F	P	S	R	H	A	R	F	M	V	N	Y	A	T	H	W	T	E	A	R	E	D	D	L	H	R	Q	W	T	R	D	A	I	E	A	L	A	P	Y	G	L	G	T	A	Y	V	N	F	T	A	D
Secondary structure
SS confidence
Disorder		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence		D	A	P	M	H	V	E	T	L	Y	S	T	T	E	F	S	R	L	V	T	L	K	N	R	L	D	P	D	N	V	F	R	N	N	H	N	I	R	P	S	A
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 31%) Beta strand ( 26%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 3w8w chain A Region: 1 - 459 Aligned: 457 Modelled: 459 Confidence: 100.0% Identity: 41% PDB header:oxidoreductase Chain: A: PDB Molecule:putative fad-dependent oxygenase encm; PDBTitle: the crystal structure of encm Phyre2 PDB 2bvf chain A Region: 9 - 459 Aligned: 442 Modelled: 451 Confidence: 100.0% Identity: 29% PDB header:oxidase Chain: A: PDB Molecule:6-hydroxy-d-nicotine oxidase; PDBTitle: crystal structure of 6-hydoxy-d-nicotine oxidase from2 arthrobacter nicotinovorans. crystal form 3 (p1) Phyre2 PDB 6eo5 chain A Region: 4 - 459 Aligned: 437 Modelled: 443 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:ppbbe-like 1 d396n; PDBTitle: physcomitrella patens bbe-like 1 variant d396n Phyre2 PDB 5l6f chain A Region: 3 - 460 Aligned: 446 Modelled: 458 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:fad linked oxidase-like protein; PDBTitle: xylooligosaccharide oxidase from myceliophthora thermophila c1 in2 complex with xylobiose Phyre2 PDB 3tsj chain A Region: 17 - 459 Aligned: 429 Modelled: 429 Confidence: 100.0% Identity: 23% PDB header:allergen, oxidoreductase Chain: A: PDB Molecule:pollen allergen phl p 4; PDBTitle: crystal structure of phl p 4, a grass pollen allergen with glucose2 dehydrogenase activity Phyre2 PDB 3rja chain A Region: 10 - 460 Aligned: 442 Modelled: 451 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:carbohydrate oxidase; PDBTitle: crystal structure of carbohydrate oxidase from microdochium nivale in2 complex with substrate analogue Phyre2 PDB 3vte chain A Region: 2 - 459 Aligned: 450 Modelled: 458 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:tetrahydrocannabinolic acid synthase; PDBTitle: crystal structure of tetrahydrocannabinolic acid synthase from2 cannabis sativa Phyre2 PDB 4ud8 chain B Region: 3 - 460 Aligned: 449 Modelled: 457 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: B: PDB Molecule:fad-binding and bbe domain-containing protein; PDBTitle: atbbe15 Phyre2 PDB 1zr6 chain A Region: 3 - 461 Aligned: 445 Modelled: 446 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:glucooligosaccharide oxidase; PDBTitle: the crystal structure of an acremonium strictum glucooligosaccharide2 oxidase reveals a novel flavinylation Phyre2 PDB 5d79 chain B Region: 19 - 459 Aligned: 432 Modelled: 441 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: B: PDB Molecule:berberine bridge enzyme-like protein; PDBTitle: structure of bbe-like #28 from arabidopsis thaliana Phyre2 PDB 3d2h chain A Region: 8 - 461 Aligned: 443 Modelled: 454 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:berberine bridge-forming enzyme; PDBTitle: structure of berberine bridge enzyme from eschscholzia californica,2 monoclinic crystal form Phyre2 PDB 2ipi chain D Region: 19 - 460 Aligned: 437 Modelled: 442 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: D: PDB Molecule:aclacinomycin oxidoreductase (aknox); PDBTitle: crystal structure of aclacinomycin oxidoreductase Phyre2 PDB 3fwa chain A Region: 8 - 459 Aligned: 442 Modelled: 452 Confidence: 100.0% Identity: 21% PDB header:flavoprotein Chain: A: PDB Molecule:reticuline oxidase; PDBTitle: structure of berberine bridge enzyme, c166a variant in complex with2 (s)-reticuline Phyre2 PDB 2wdw chain B Region: 12 - 459 Aligned: 448 Modelled: 448 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: B: PDB Molecule:putative hexose oxidase; PDBTitle: the native crystal structure of the primary hexose oxidase (2 dbv29) in antibiotic a40926 biosynthesis Phyre2 PDB 5i1w chain D Region: 18 - 459 Aligned: 440 Modelled: 442 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: D: PDB Molecule:crmk; PDBTitle: crystal structure of crmk, a flavoenzyme involved in the shunt product2 recycling mechanism in caerulomycin biosynthesis Phyre2 PDB 4bc9 chain C Region: 2 - 457 Aligned: 449 Modelled: 456 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: C: PDB Molecule:alkyldihydroxyacetonephosphate synthase, peroxisomal; PDBTitle: mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct2 with cyanoethyl Phyre2 PDB 3pop chain D Region: 19 - 458 Aligned: 439 Modelled: 440 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: D: PDB Molecule:gilr oxidase; PDBTitle: the crystal structure of gilr, an oxidoreductase that catalyzes the2 terminal step of gilvocarcin biosynthesis Phyre2 PDB 3bw7 chain A Region: 10 - 457 Aligned: 445 Modelled: 448 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:cytokinin dehydrogenase 1; PDBTitle: maize cytokinin oxidase/dehydrogenase complexed with the allenic2 cytokinin analog ha-1 Phyre2 PDB 4oal chain B Region: 17 - 459 Aligned: 428 Modelled: 442 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: B: PDB Molecule:cytokinin dehydrogenase 4; PDBTitle: crystal structure of maize cytokinin oxidase/dehydrogenase 4 (zmcko4)2 in complex with phenylurea inhibitor cppu in alternative spacegroup Phyre2 PDB 2y3r chain C Region: 18 - 458 Aligned: 436 Modelled: 436 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: C: PDB Molecule:taml; PDBTitle: structure of the tirandamycin-bound fad-dependent tirandamycin oxidase2 taml in p21 space group Phyre2 1 c3w8wA_ 2 c2bvfA_ 3 c6eo5A_ 4 c5l6fA_ 5 c3tsjA_ 6 c3rjaA_ 7 c3vteA_ 8 c4ud8B_ 9 c1zr6A_ 10 c5d79B_ 11 c3d2hA_ 12 c2ipiD_ 13 c3fwaA_ 14 c2wdwB_ 15 c5i1wD_ 16 c4bc9C_ 17 c3popD_ 18 c3bw7A_ 19 c4oalB_ 20 c2y3rC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162