1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	G	Q	A	A	N	L	V	L	A	T	W	I	S	V	V	N	F	W	A	W	N	L	I	G	P	L	S	T	S	Y	A	R	D	M	S	L	S	S	A	E	A	S	L	L	V	A	T	P	I	L	V	G	A	L	G	R	I	V
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	P	L	T	D	R	F	G	G	R	A	M	L	I	A	V	T	L	A	S	I	L	P	V	L	A	V	G	V	A	A	T	M	G	S	Y	A	L	L	V	F	F	G	L	F	L	G	V	A	G	T	I	F	A	V	G	I	P	F
Secondary structure
SS confidence
Disorder																																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	N	N	W	Y	Q	P	A	R	R	G	F	S	T	G	V	F	G	M	G	M	V	G	T	A	L	S	A	F	F	T	P	R	F	V	R	W	F	G	L	F	T	T	H	A	I	V	A	A	A	L	A	S	T	A	V	V	A	M	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	L	R	D	A	P	Y	F	R	P	N	A	D	P	V	L	P	R	L	K	A	A	A	R	L	P	V	T	W	E	M	S	F	L	Y	A	I	V	F	G	G	F	V	A	F	S	N	Y	L	P	T	Y	I	T	T	I	Y	G	F	S
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	V	D	A	G	A	R	T	A	G	F	A	L	A	A	V	L	A	R	P	V	G	G	W	L	S	D	R	I	A	P	R	H	V	V	L	A	S	L	A	G	T	A	L	L	A	F	A	A	A	L	Q	P	P	P	E	V	W	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	T	F	I	T	L	A	V	C	L	G	V	G	T	G	G	V	F	A	W	V	A	R	R	A	P	A	A	S	V	G	S	V	T	G	I	V	A	A	A	G	G	L	G	G	Y	F	P	P	L	V	M	G	A	T	Y	D	P	V	D
Secondary structure
SS confidence
Disorder																									?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.
Sequence		N	D	Y	T	V	G	L	L	L	L	V	A	T	A	L	V	A	C	T	Y	T	A	L	H	A	R	E	P	V	S	E	E	A	S	R
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 84%) Beta strand ( 0%) TM helix ( 66%) (View membrane topology prediction)

Rank Aligned region

PDB 6e9o chain A Region: 2 - 390 Aligned: 385 Modelled: 389 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 3wdo chain A Region: 3 - 391 Aligned: 384 Modelled: 389 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4zp0 chain A Region: 2 - 384 Aligned: 380 Modelled: 383 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 1pw4 chain A Region: 2 - 392 Aligned: 388 Modelled: 391 Confidence: 100.0% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6g9x chain B Region: 5 - 390 Aligned: 368 Modelled: 375 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 2gfp chain A Region: 8 - 377 Aligned: 367 Modelled: 370 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 1pv7 chain A Region: 4 - 395 Aligned: 389 Modelled: 392 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 4 - 395 Aligned: 389 Modelled: 392 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 4lds chain B Region: 8 - 389 Aligned: 378 Modelled: 382 Confidence: 100.0% Identity: 13% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 4cl5 chain B Region: 1 - 394 Aligned: 392 Modelled: 394 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 6gs7 chain A Region: 3 - 387 Aligned: 385 Modelled: 385 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4w6v chain A Region: 2 - 390 Aligned: 389 Modelled: 387 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 4iu8 chain A Region: 2 - 385 Aligned: 383 Modelled: 383 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 3o7p chain A Region: 6 - 386 Aligned: 376 Modelled: 381 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4aps chain B Region: 4 - 380 Aligned: 377 Modelled: 377 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 4iky chain A Region: 3 - 390 Aligned: 386 Modelled: 388 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4j05 chain A Region: 4 - 395 Aligned: 390 Modelled: 392 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 6exs chain A Region: 2 - 387 Aligned: 386 Modelled: 386 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 5ayn chain A Region: 6 - 387 Aligned: 380 Modelled: 382 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 39 (iron-regulated transporter); PDBTitle: crystal structure of a bacterial homologue of iron transporter2 ferroportin in outward-facing state Phyre2 PDB 4q65 chain A Region: 4 - 386 Aligned: 383 Modelled: 383 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:dipeptide permease d; PDBTitle: structure of the e. coli peptide transporter ybgh Phyre2 1 c6e9oA_ 2 c3wdoA_ 3 c4zp0A_ 4 d1pw4a_ 5 c6g9xB_ 6 c2gfpA_ 7 d1pv7a_ 8 c1pv7B_ 9 c4ldsB_ 10 c4cl5B_ 11 c6gs7A_ 12 c4w6vA_ 13 c4iu8A_ 14 c3o7pA_ 15 c4apsB_ 16 c4ikyA_ 17 c4j05A_ 18 c6exsA_ 19 c5aynA_ 20 c4q65A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47