1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	I	D	T	S	A	L	V	A	M	L	N	D	E	P	E	A	Q	R	F	E	I	A	V	A	A	D	H	V	W	L	M	S	T	A	S	Y	P	E	M	A	T	V	I	E	T	R	F	G	E	P	G	G	R	E	P	K	V	S
Secondary structure
SS confidence
Disorder		?	?	?	?																							?	?	?	?	?	?																?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.
Sequence		G	Q	P	L	L	Y	K	G	D	D	F	A	C	I	D	I	R	A	V	L	A	G
Secondary structure
SS confidence
Disorder		?																			?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 54%) Beta strand ( 7%)

Rank Aligned region

PDB 4xgr chain G Region: 2 - 79 Aligned: 78 Modelled: 78 Confidence: 99.4% Identity: 67% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 5wzf chain B Region: 1 - 80 Aligned: 80 Modelled: 80 Confidence: 97.4% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 2fe1 chain A Region: 2 - 53 Aligned: 52 Modelled: 52 Confidence: 97.2% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 2fe1 chain A domain 1 Region: 2 - 53 Aligned: 52 Modelled: 52 Confidence: 97.2% Identity: 21% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 97.0% Identity: 14% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3dbo chain B Region: 2 - 75 Aligned: 64 Modelled: 74 Confidence: 96.8% Identity: 23% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 3zvk chain C Region: 2 - 75 Aligned: 74 Modelled: 74 Confidence: 96.7% Identity: 15% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 3h87 chain B Region: 2 - 71 Aligned: 68 Modelled: 70 Confidence: 96.5% Identity: 21% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 1v8p chain A Region: 2 - 53 Aligned: 46 Modelled: 52 Confidence: 95.9% Identity: 13% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v8p chain K Region: 2 - 53 Aligned: 46 Modelled: 52 Confidence: 95.7% Identity: 13% PDB header:structural genomics, unknown function Chain: K: PDB Molecule:hypothetical protein pae2754; PDBTitle: crystal structure of pae2754 from pyrobaculum aerophilum Phyre2 PDB 6a7v chain G Region: 1 - 73 Aligned: 73 Modelled: 73 Confidence: 95.7% Identity: 19% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 5x3t chain D Region: 2 - 50 Aligned: 49 Modelled: 49 Confidence: 95.2% Identity: 29% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5sv2 chain A Region: 2 - 73 Aligned: 70 Modelled: 72 Confidence: 93.7% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 3tnd chain C Region: 2 - 50 Aligned: 48 Modelled: 49 Confidence: 92.3% Identity: 15% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5l6m chain C Region: 2 - 73 Aligned: 70 Modelled: 72 Confidence: 91.9% Identity: 21% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 4chg chain C Region: 2 - 41 Aligned: 40 Modelled: 36 Confidence: 91.8% Identity: 23% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 6nkl chain A Region: 2 - 50 Aligned: 49 Modelled: 49 Confidence: 90.6% Identity: 14% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 1y82 chain A domain 1 Region: 1 - 48 Aligned: 46 Modelled: 48 Confidence: 65.8% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v96 chain A domain 1 Region: 1 - 40 Aligned: 38 Modelled: 40 Confidence: 50.6% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1w8i chain A Region: 2 - 48 Aligned: 47 Modelled: 47 Confidence: 40.1% Identity: 11% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c4xgrG_ 2 c5wzfB_ 3 c2fe1A_ 4 d2fe1a1 5 d2h1ca1 6 c3dboB_ 7 c3zvkC_ 8 c3h87B_ 9 d1v8pa_ 10 c1v8pK_ 11 c6a7vG_ 12 c5x3tD_ 13 c5sv2A_ 14 c3tndC_ 15 c5l6mC_ 16 c4chgC_ 17 c6nklA_ 18 d1y82a1 19 d1v96a1 20 d1w8ia_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47