1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	E	A	H	P	A	H	P	A	D	A	G	R	P	G	G	P	I	Q	G	A	R	R	G	A	A	M	T	P	I	T	A	L	P	T	E	L	A	A	M	R	E	V	V	E	T	L	A	P	I	E	R	A	A	G	E	P	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?	?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	K	A	A	E	W	I	V	E	R	L	R	T	A	G	A	Q	D	A	R	I	E	E	E	Q	Y	L	D	G	Y	P	R	L	H	L	K	L	S	V	I	G	V	A	A	G	V	A	G	L	L	S	R	R	L	R	I	P	A	A	L
Secondary structure
SS confidence
Disorder																										?	?	?	?									?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	V	G	A	G	L	A	I	A	D	D	C	A	N	G	P	R	I	V	R	K	R	T	E	T	P	R	T	T	W	N	A	V	A	E	A	G	D	P	A	G	Q	L	T	V	V	V	C	A	H	H	D	A	A	H	S	G	K	F
Secondary structure
SS confidence
Disorder																						?				?	?	?	?	?	?	?	?				?	?	?																				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	E	A	H	I	E	E	V	M	V	E	L	F	P	G	I	V	E	R	I	D	T	Q	L	P	N	W	W	G	P	I	L	A	P	A	L	A	G	V	G	A	L	R	G	S	R	P	M	M	I	A	G	T	V	G	S	A	L	A	A
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?	?	?	?	?	?			?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	F	A	D	I	A	R	S	P	V	V	P	G	A	N	D	N	L	S	A	V	A	L	L	V	A	L	A	E	R	L	R	E	R	P	V	K	G	V	R	V	L	L	V	S	L	G	A	E	E	T	L	Q	G	G	I	Y	G	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	A	R	H	K	P	E	L	D	R	D	R	T	Y	F	L	N	F	D	T	I	G	S	P	E	L	I	M	L	E	G	E	G	P	T	V	M	E	D	Y	F	Y	R	P	F	R	D	L	V	I	R	A	A	E	R	A	D	A	P	L
Secondary structure
SS confidence
Disorder																																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	R	G	I	R	S	R	N	S	T	D	A	V	L	M	S	R	A	G	Y	P	T	A	C	F	V	S	I	N	R	H	K	S	V	A	N	Y	H	L	M	S	D	T	P	E	N	L	C	Y	E	T	V	S	H	A	V	T	V	A	E
Secondary structure
SS confidence
Disorder				?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		S	V	I	R	E	L	A	R
Secondary structure
SS confidence
Disorder								?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 39%) Beta strand ( 17%) TM helix ( 8%) (View membrane topology prediction)

Rank Aligned region

PDB 3iib chain A Region: 42 - 427 Aligned: 377 Modelled: 384 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:peptidase m28; PDBTitle: crystal structure of peptidase m28 precursor (yp_926796.1) from2 shewanella amazonensis sb2b at 1.70 a resolution Phyre2 PDB 2ek8 chain A Region: 37 - 428 Aligned: 378 Modelled: 392 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase; PDBTitle: aminopeptidase from aneurinibacillus sp. strain am-1 Phyre2 PDB 4twe chain A Region: 39 - 427 Aligned: 378 Modelled: 389 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:n-acetylated-alpha-linked acidic dipeptidase-like protein; PDBTitle: structure of ligand-free n-acetylated-alpha-linked-acidic-dipeptidase2 like protein (naaladasel) Phyre2 PDB 2oot chain A Region: 39 - 427 Aligned: 381 Modelled: 389 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:glutamate carboxypeptidase 2; PDBTitle: a high resolution structure of ligand-free human glutamate2 carboxypeptidase ii Phyre2 PDB 3rbu chain A Region: 39 - 427 Aligned: 383 Modelled: 388 Confidence: 100.0% Identity: 15% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:glutamate carboxypeptidase 2; PDBTitle: n-terminally avitev-tagged human glutamate carboxypeptidase ii in2 complex with 2-pmpa Phyre2 PDB 1cx8 chain F Region: 41 - 427 Aligned: 375 Modelled: 381 Confidence: 100.0% Identity: 13% PDB header:metal transport Chain: F: PDB Molecule:transferrin receptor protein; PDBTitle: crystal structure of the ectodomain of human transferrin receptor Phyre2 PDB 1tkj chain A domain 1 Region: 29 - 427 Aligned: 257 Modelled: 266 Confidence: 100.0% Identity: 24% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 5gne chain A Region: 39 - 427 Aligned: 259 Modelled: 262 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase; PDBTitle: crystal structure of lapb from legionella pneumophila Phyre2 PDB 6esl chain B Region: 37 - 427 Aligned: 257 Modelled: 262 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:bacterial leucyl aminopeptidase; PDBTitle: crystal structure of the legionella pneumoppila lapa Phyre2 PDB 4fbe chain A Region: 37 - 426 Aligned: 256 Modelled: 262 Confidence: 100.0% Identity: 19% PDB header:transferase, hydrolase Chain: A: PDB Molecule:cg5976, isoform b; PDBTitle: crystal structure of the c136a/c164a variant of mitochondrial isoform2 of glutaminyl cyclase from drosophila melanogaster Phyre2 PDB 4f9v chain B Region: 36 - 428 Aligned: 259 Modelled: 265 Confidence: 100.0% Identity: 18% PDB header:transferase, hydrolase Chain: B: PDB Molecule:cg32412; PDBTitle: structure of c113a/c136a mutant variant of glycosylated glutaminyl2 cyclase from drosophila melanogaster Phyre2 PDB 1rtq chain A Region: 37 - 427 Aligned: 258 Modelled: 261 Confidence: 100.0% Identity: 17% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 6qql chain B Region: 29 - 426 Aligned: 262 Modelled: 267 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:glutamine cyclotransferase; PDBTitle: crystal structure of porphyromonas gingivalis glutaminyl cyclase Phyre2 PDB 4mhz chain A Region: 36 - 425 Aligned: 255 Modelled: 261 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:glutaminyl cyclase, putative; PDBTitle: crystal structure of apo-form glutaminyl cyclase from ixodes2 scapularis in complex with pbd150 Phyre2 PDB 3tc8 chain A Region: 27 - 425 Aligned: 263 Modelled: 268 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase; PDBTitle: crystal structure of a zn-dependent exopeptidase (bdi_3547) from2 parabacteroides distasonis atcc 8503 at 1.06 a resolution Phyre2 PDB 3pb6 chain X Region: 18 - 425 Aligned: 273 Modelled: 279 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: X: PDB Molecule:glutaminyl-peptide cyclotransferase-like protein; PDBTitle: crystal structure of the catalytic domain of human golgi-resident2 glutaminyl cyclase at ph 6.5 Phyre2 PDB 4fuu chain A Region: 39 - 425 Aligned: 250 Modelled: 259 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase; PDBTitle: crystal structure of a leucine aminopeptidase precursor (bt_2548) from2 bacteroides thetaiotaomicron vpi-5482 at 1.30 a resolution Phyre2 PDB 1de4 chain C domain 3 Region: 210 - 427 Aligned: 210 Modelled: 218 Confidence: 100.0% Identity: 15% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: FolH catalytic domain-like Phyre2 PDB 2afw chain A domain 1 Region: 36 - 426 Aligned: 258 Modelled: 265 Confidence: 100.0% Identity: 18% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Glutaminyl-peptide cyclotransferase-like Phyre2 PDB 3bi1 chain A domain 3 Region: 39 - 427 Aligned: 257 Modelled: 259 Confidence: 100.0% Identity: 16% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: FolH catalytic domain-like Phyre2 1 c3iibA_ 2 c2ek8A_ 3 c4tweA_ 4 c2ootA_ 5 c3rbuA_ 6 c1cx8F_ 7 d1tkja1 8 c5gneA_ 9 c6eslB_ 10 c4fbeA_ 11 c4f9vB_ 12 d1rtqa_ 13 c6qqlB_ 14 c4mhzA_ 15 c3tc8A_ 16 c3pb6X_ 17 c4fuuA_ 18 d1de4c3 19 d2afwa1 20 d3bi1a3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119