1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	Q	Q	S	T	R	T	D	I	T	V	N	V	D	G	F	W	M	L	Q	A	L	L	D	I	R	H	V	A	P	E	L	R	C	R	P	Y	V	S	T	D	S	N	D	W	L	N	E	H	P	G	M	A	V	M	R	E	Q	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																												?	?	?	?	?			?	?															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	V	V	N	D	A	V	N	E	Q	V	A	A	R	M	K	V	L	A	A	P	D	L	E	V	V	A	L	L	S	R	G	K	L	L	Y	G	V	I	D	D	E	N	Q	P	P	G	S	R	D	I	P	D	N	E	F	R	V	V	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																								?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	R	R	G	Q	H	W	V	S	A	V	R	V	G	N	D	I	T	V	D	D	V	T	V	S	D	S	A	S	I	A	A	L	V	M	D	G	L	E	S	I	H	H	A	D	P	A	A	I	N	A	V	N	V	P	M	E	E	M	L
Secondary structure
SS confidence
Disorder																									?	?	?	?			?						?		?	?	?	?	?		?	?	?							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	A	T	K	S	W	Q	E	S	G	F	N	V	F	S	G	G	D	L	R	R	M	G	I	S	A	A	T	V	A	A	L	G	Q	A	L	S	D	P	A	A	E	V	A	V	Y	A	R	Q	Y	R	D	D	A	K	G	P	S	A	S
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?																						?	?	?	?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	S	L	K	D	G	S	G	G	R	I	A	L	Y	Q	Q	A	R	T	A	G	S	G	E	A	W	L	A	I	C	P	A	T	P	Q	L	V	Q	V	G	V	K	T	V	L	D	T	L	P	Y	G	E	W	K	T	H	S	R	V
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?																											?	?	?	?	?	?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 31%) Beta strand ( 23%)

Rank Aligned region

PDB 4kxr chain C Region: 8 - 298 Aligned: 276 Modelled: 291 Confidence: 100.0% Identity: 99% PDB header:protein transport Chain: C: PDB Molecule:espg5; PDBTitle: structure of the mycobacterium tuberculosis type vii secretion system2 chaperone espg5 in complex with pe25-ppe41 dimer Phyre2 PDB 4l4w chain B Region: 7 - 295 Aligned: 262 Modelled: 270 Confidence: 100.0% Identity: 21% PDB header:protein transport Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system Phyre2 PDB 4w4i chain A Region: 8 - 291 Aligned: 268 Modelled: 284 Confidence: 100.0% Identity: 21% PDB header:protein transport Chain: A: PDB Molecule:esx-3 secretion-associated protein espg3; PDBTitle: crystal structure of espg3 from the esx-3 type vii secretion system of2 m. tuberculosis Phyre2 PDB 4rcl chain B Region: 7 - 295 Aligned: 234 Modelled: 239 Confidence: 100.0% Identity: 20% PDB header:chaperone Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system, space group p43212 Phyre2 PDB 5vba chain A Region: 10 - 295 Aligned: 235 Modelled: 247 Confidence: 100.0% Identity: 26% PDB header:chaperone, hydrolase Chain: A: PDB Molecule:lysozyme, esx-1 secretion-associated protein espg1 chimera; PDBTitle: structure of espg1 chaperone from the type vii (esx-1) secretion2 system determined with the assistance of n-terminal t4 lysozyme3 fusion Phyre2 PDB 1w79 chain A domain 1 Region: 238 - 296 Aligned: 51 Modelled: 59 Confidence: 24.6% Identity: 16% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 4rdk chain B Region: 242 - 278 Aligned: 33 Modelled: 37 Confidence: 17.6% Identity: 21% PDB header:viral protein Chain: B: PDB Molecule:capsid; PDBTitle: crystal structure of norovirus boxer p domain in complex with lewis b2 tetrasaccharide Phyre2 PDB 3a3e chain B Region: 235 - 296 Aligned: 54 Modelled: 62 Confidence: 15.5% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 (dacb) from2 haemophilus influenzae, complexed with novel beta-lactam (cmv) Phyre2 PDB 1hyn chain P Region: 274 - 300 Aligned: 27 Modelled: 27 Confidence: 13.8% Identity: 15% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: Anion transport protein, cytoplasmic domain Phyre2 PDB 1ppv chain A Region: 230 - 290 Aligned: 59 Modelled: 61 Confidence: 13.1% Identity: 12% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 1hyn chain Q Region: 274 - 300 Aligned: 27 Modelled: 27 Confidence: 11.8% Identity: 15% PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human erythrocyte band-2 3 protein Phyre2 PDB 1rk8 chain C Region: 290 - 300 Aligned: 11 Modelled: 11 Confidence: 11.5% Identity: 45% Fold: WW domain-like Superfamily: Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain Family: Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain Phyre2 PDB 1rk8 chain C Region: 290 - 300 Aligned: 11 Modelled: 11 Confidence: 11.5% Identity: 45% PDB header:translation Chain: C: PDB Molecule:within the bgcn gene intron protein; PDBTitle: structure of the cytosolic protein pym bound to the mago-2 y14 core of the exon junction complex Phyre2 PDB 2ei5 chain B Region: 273 - 294 Aligned: 22 Modelled: 22 Confidence: 11.2% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein ttha0061; PDBTitle: crystal structure of hypothetical protein(ttha0061) from thermus2 thermophilus Phyre2 PDB 1u94 chain A domain 2 Region: 291 - 298 Aligned: 8 Modelled: 8 Confidence: 10.3% Identity: 25% Fold: Anti-LPS factor/recA domain Superfamily: RecA protein, C-terminal domain Family: RecA protein, C-terminal domain Phyre2 PDB 1mo6 chain A domain 2 Region: 291 - 298 Aligned: 8 Modelled: 8 Confidence: 10.2% Identity: 38% Fold: Anti-LPS factor/recA domain Superfamily: RecA protein, C-terminal domain Family: RecA protein, C-terminal domain Phyre2 PDB 2fvv chain A domain 1 Region: 230 - 290 Aligned: 56 Modelled: 61 Confidence: 10.1% Identity: 21% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2fvv chain A Region: 230 - 290 Aligned: 56 Modelled: 61 Confidence: 10.1% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:diphosphoinositol polyphosphate phosphohydrolase 1; PDBTitle: human diphosphoinositol polyphosphate phosphohydrolase 1 Phyre2 PDB 2v4o chain B Region: 267 - 294 Aligned: 28 Modelled: 28 Confidence: 10.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:multifunctional protein sur e; PDBTitle: crystal structure of salmonella typhimurium sure at 2.752 angstrom resolution in monoclinic form Phyre2 PDB 1rrq chain A domain 2 Region: 236 - 290 Aligned: 53 Modelled: 55 Confidence: 9.7% Identity: 11% Fold: Nudix Superfamily: Nudix Family: MutY C-terminal domain-like Phyre2 1 c4kxrC_ 2 c4l4wB_ 3 c4w4iA_ 4 c4rclB_ 5 c5vbaA_ 6 d1w79a1 7 c4rdkB_ 8 c3a3eB_ 9 d1hynp_ 10 d1ppva_ 11 c1hynQ_ 12 d1rk8c_ 13 c1rk8C_ 14 c2ei5B_ 15 d1u94a2 16 d1mo6a2 17 d2fvva1 18 c2fvvA_ 19 c2v4oB_ 20 d1rrqa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67