1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	A	Q	R	S	F	G	L	A	L	S	W	P	R	V	T	A	V	F	L	V	D	V	L	I	L	A	V	A	S	H	C	P	D	S	W	Q	A	D	H	H	V	A	W	W	V	G	V	G	V	A	A	V	V	T	L	L	S	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																						?		?	?		?	?																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	S	Y	H	G	I	T	V	I	S	G	L	A	T	W	V	R	D	W	S	A	D	P	G	T	T	L	G	A	G	C	T	P	A	I	D	H	Q	R	R	F	G	R	D	T	V	G	V	R	E	Y	N	G	R	L	V	S	V	I	E
Secondary structure
SS confidence
Disorder				?		?																?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	T	C	G	E	S	G	P	S	G	R	H	W	H	R	K	S	P	V	P	M	L	P	V	V	A	V	A	D	G	L	R	Q	F	D	I	H	L	D	G	I	D	I	V	S	V	L	V	R	G	G	V	D	A	A	K	A	S	A	S
Secondary structure
SS confidence
Disorder			?	?	?		?	?					?	?	?	?	?	?	?	?																										?	?	?			?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	Q	E	W	E	P	Q	G	W	K	S	E	E	R	A	G	D	R	T	V	A	D	R	R	R	T	W	L	V	L	R	M	N	P	Q	R	N	V	A	A	V	A	C	R	D	S	L	A	S	T	L	V	A	A	T	E	R	L	V	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?									?	?	?	?	?															?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	L	D	G	Q	S	C	A	A	R	P	V	T	A	D	E	L	T	E	V	D	S	A	V	L	A	D	L	E	P	T	W	S	R	P	G	W	R	H	L	K	H	F	N	G	Y	A	T	S	F	W	V	T	P	S	D	I	T	S	E
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	L	D	E	L	C	L	P	D	S	P	E	V	G	T	T	V	V	T	V	R	L	T	T	R	V	G	S	P	A	L	S	A	W	V	R	Y	H	S	D	T	R	L	P	K	E	V	A	A	G	L	N	R	L	T	G	R	Q	L	A
Secondary structure
SS confidence
Disorder														?										?	?	?	?	?	?														?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
Sequence		A	V	R	A	S	L	P	A	P	T	H	R	P	L	L	V	I	P	S	R	N	L	R	D	H	D	E	L	V	L	P	V	G	Q	E	L	E	H	A	T	S	S	F	V	G	Q
Secondary structure
SS confidence
Disorder														?			?					?	?	?	?	?	?								?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 32%) Beta strand ( 22%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 2k42 chain B Region: 234 - 247 Aligned: 14 Modelled: 14 Confidence: 26.4% Identity: 29% PDB header:signaling protein Chain: B: PDB Molecule:espfu; PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector Phyre2 PDB 2lnh chain C Region: 234 - 247 Aligned: 14 Modelled: 14 Confidence: 20.6% Identity: 29% PDB header:signaling protein/protein binding Chain: C: PDB Molecule:secreted effector protein espf(u); PDBTitle: enterohaemorrhagic e. coli (ehec) exploits a tryptophan switch to2 hijack host f-actin assembly Phyre2 PDB 5yq7 chain L Region: 39 - 79 Aligned: 39 Modelled: 41 Confidence: 17.9% Identity: 28% PDB header:photosynthesis Chain: L: PDB Molecule:precursor for l subunits of photosynthetic reaction center; PDBTitle: cryo-em structure of the rc-lh core complex from roseiflexus2 castenholzii Phyre2 PDB 3etj chain A domain 2 Region: 147 - 170 Aligned: 23 Modelled: 24 Confidence: 10.4% Identity: 30% Fold: PreATP-grasp domain Superfamily: PreATP-grasp domain Family: BC N-terminal domain-like Phyre2 PDB 3slu chain B Region: 280 - 291 Aligned: 12 Modelled: 12 Confidence: 8.9% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:m23 peptidase domain protein; PDBTitle: crystal structure of nmb0315 Phyre2 PDB 4z29 chain B Region: 305 - 358 Aligned: 53 Modelled: 54 Confidence: 7.8% Identity: 17% PDB header:signaling protein Chain: B: PDB Molecule:magnetotaxis protein mtxa; PDBTitle: crystal structure of the magnetobacterial protein mtxa c-terminal2 domain Phyre2 PDB 3boe chain A domain 1 Region: 238 - 257 Aligned: 20 Modelled: 20 Confidence: 6.7% Identity: 25% Fold: CdCA1 repeat-like Superfamily: CdCA1 repeat-like Family: CdCA1 repeat-like Phyre2 PDB 4pcv chain B Region: 229 - 267 Aligned: 39 Modelled: 39 Confidence: 6.7% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:bdca (yjgi); PDBTitle: the structure of bdca (yjgi) from e. coli Phyre2 PDB 2dae chain A Region: 140 - 159 Aligned: 20 Modelled: 20 Confidence: 5.6% Identity: 35% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0733 protein; PDBTitle: solution structure of the n-terminal cue domain in the2 human mitogen-activated protein kinase kinase kinase 73 interacting protein 2 (map3k7ip2) Phyre2 1 c2k42B_ 2 c2lnhC_ 3 c5yq7L_ 4 d3etja2 5 c3sluB_ 6 c4z29B_ 7 d3boea1 8 c4pcvB_ 9 c2daeA_