1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	L	Q	R	T	M	G	Q	C	R	P	M	R	M	L	V	A	L	L	L	S	A	A	T	M	I	G	L	A	A	P	G	K	A	D	P	T	G	D	D	A	A	F	L	A	A	L	D	Q	A	G	I	T	Y	A	D	P	G	H
Secondary structure
SS confidence
Disorder		?	?	?					?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		A	I	T	A	A	K	A	M	C	G	L	C	A	N	G	V	T	G	L	Q	L	V	A	D	L	R	D	Y	N	P	G	L	T	M	D	S	A	A	K	F	A	A	I	A	S	G	A	Y	C	P	E	H	L	E	H	H	P	S
Secondary structure
SS confidence
Disorder																												?			?	?	?																						?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 14%) (View membrane topology prediction)

Rank Aligned region

PDB 6c3r chain B Region: 84 - 112 Aligned: 29 Modelled: 29 Confidence: 63.7% Identity: 24% PDB header:viral protein Chain: B: PDB Molecule:cricket paralysis virus 1a protein; PDBTitle: cricket paralysis virus rnai suppressor protein crpv-1a Phyre2 PDB 2csu chain A domain 3 Region: 37 - 64 Aligned: 28 Modelled: 28 Confidence: 22.4% Identity: 25% Fold: Flavodoxin-like Superfamily: Succinyl-CoA synthetase domains Family: Succinyl-CoA synthetase domains Phyre2 PDB 1vjq chain B Region: 37 - 56 Aligned: 20 Modelled: 20 Confidence: 16.9% Identity: 30% PDB header:structural genomics, de novo protein Chain: B: PDB Molecule:designed protein; PDBTitle: designed protein based on backbone conformation of2 procarboxypeptidase-a (1aye) with sidechains chosen for maximal3 predicted stability. Phyre2 PDB 1mke chain A domain 1 Region: 52 - 74 Aligned: 23 Modelled: 23 Confidence: 16.6% Identity: 22% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Enabled/VASP homology 1 domain (EVH1 domain) Phyre2 PDB 2mp6 chain A Region: 3 - 14 Aligned: 12 Modelled: 12 Confidence: 13.4% Identity: 67% PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signaling 5; PDBTitle: structure and function of the jak interaction region in the2 intrinsically disordered n-terminus of socs5 Phyre2 PDB 4ina chain A Region: 28 - 55 Aligned: 24 Modelled: 28 Confidence: 12.6% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine dehydrogenase; PDBTitle: crystal structure of the q7mss8_wolsu protein from wolinella2 succinogenes. northeast structural genomics consortium target wsr35 Phyre2 PDB 4rl6 chain A Region: 11 - 55 Aligned: 41 Modelled: 45 Confidence: 12.5% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine dehydrogenase; PDBTitle: crystal structure of the q04l03_strp2 protein from streptococcus2 pneumoniae. northeast structural genomics consortium target spr105 Phyre2 PDB 5uqd chain A Region: 41 - 56 Aligned: 16 Modelled: 16 Confidence: 11.9% Identity: 44% PDB header:oxidoreductase Chain: A: PDB Molecule:dumpy: shorter than wild-type; PDBTitle: dpy-21 in complex with fe(ii) and alpha-ketoglutarate Phyre2 PDB 5l78 chain A Region: 12 - 55 Aligned: 41 Modelled: 44 Confidence: 11.7% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:alpha-aminoadipic semialdehyde synthase, mitochondrial; PDBTitle: crystal structure of human aminoadipate semialdehyde synthase,2 saccharopine dehydrogenase domain (in nad+ bound form) Phyre2 PDB 5k9x chain A Region: 52 - 87 Aligned: 34 Modelled: 32 Confidence: 11.2% Identity: 24% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of tryptophan synthase alpha chain from legionella2 pneumophila subsp. pneumophila Phyre2 PDB 2lwe chain A Region: 42 - 56 Aligned: 15 Modelled: 15 Confidence: 10.3% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:probable atp-dependent rna helicase ddx58; PDBTitle: solution structure of mutant (t170e) second card of human rig-i Phyre2 PDB 2ekc chain A Region: 52 - 87 Aligned: 34 Modelled: 36 Confidence: 9.4% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 Phyre2 PDB 3ss4 chain C Region: 43 - 58 Aligned: 16 Modelled: 16 Confidence: 9.4% Identity: 38% PDB header:hydrolase Chain: C: PDB Molecule:glutaminase c; PDBTitle: crystal structure of mouse glutaminase c, phosphate-bound form Phyre2 PDB 1p9s chain A Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 9.2% Identity: 57% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Viral cysteine protease of trypsin fold Phyre2 PDB 2duc chain A domain 1 Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 9.1% Identity: 57% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Viral cysteine protease of trypsin fold Phyre2 PDB 3d23 chain A Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 8.7% Identity: 57% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:3c-like proteinase; PDBTitle: main protease of hcov-hku1 Phyre2 PDB 1lvo chain A Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 8.1% Identity: 43% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Viral cysteine protease of trypsin fold Phyre2 PDB 4gic chain B Region: 105 - 114 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 50% PDB header:oxidoreductase Chain: B: PDB Molecule:histidinol dehydrogenase; PDBTitle: crystal structure of a putative histidinol dehydrogenase (target psi-2 014034) from methylococcus capsulatus Phyre2 PDB 2q6f chain B Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 8.1% Identity: 57% PDB header:hydrolase Chain: B: PDB Molecule:infectious bronchitis virus (ibv) main protease; PDBTitle: crystal structure of infectious bronchitis virus (ibv) main protease2 in complex with a michael acceptor inhibitor n3 Phyre2 PDB 4xfq chain B Region: 107 - 113 Aligned: 7 Modelled: 7 Confidence: 7.8% Identity: 43% PDB header:hydrolase Chain: B: PDB Molecule:pedv main protease; PDBTitle: crystal structure basis for pedv 3c like protease Phyre2 1 c6c3rB_ 2 d2csua3 3 c1vjqB_ 4 d1mkea1 5 c2mp6A_ 6 c4inaA_ 7 c4rl6A_ 8 c5uqdA_ 9 c5l78A_ 10 c5k9xA_ 11 c2lweA_ 12 c2ekcA_ 13 c3ss4C_ 14 d1p9sa_ 15 d2duca1 16 c3d23A_ 17 d1lvoa_ 18 c4gicB_ 19 c2q6fB_ 20 c4xfqB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52