1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	P	V	L	T	Q	N	R	V	L	T	V	P	N	M	L	S	V	I	R	L	A	L	I	P	A	F	V	Y	V	V	L	S	A	H	A	N	G	W	G	V	A	I	L	V	F	S	G	V	S	D	W	A	D	G	K	I	A	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	N	Q	S	S	R	L	G	A	L	L	D	P	A	V	D	R	L	Y	M	V	T	V	P	I	V	F	G	L	S	G	I	V	P	W	W	F	V	L	T	L	L	T	R	D	A	L	L	A	G	T	L	P	L	L	W	S	R	G
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	A	L	P	V	T	Y	V	G	K	A	A	T	F	G	F	M	V	G	F	P	T	I	L	L	G	Q	C	D	P	L	W	S	H	V	L	L	A	C	G	W	A	F	L	I	W	G	M	Y	A	Y	L	W	A	F	V	L	Y	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.
Sequence		V	Q	M	T	M	V	V	R	Q	M	P	K	L	K	G	R	A	H	R	P	A	A	Q	N	A	G	E	R	G
Secondary structure
SS confidence
Disorder										?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 57%) (View membrane topology prediction)

Rank Aligned region

PDB 6h59 chain B Region: 9 - 192 Aligned: 178 Modelled: 184 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:cdp-diacylglycerol--inositol 3-phosphatidyltransferase; PDBTitle: crystal structure of mycobacterium tuberculosis phosphatidylinositol2 phosphate synthase (pgsa1) with cdp-dag bound Phyre2 PDB 5d92 chain B Region: 14 - 187 Aligned: 169 Modelled: 174 Confidence: 99.9% Identity: 20% PDB header:membrane protein Chain: B: PDB Molecule:af2299 protein,phosphatidylinositol synthase; PDBTitle: structure of a phosphatidylinositolphosphate (pip) synthase from2 renibacterium salmoninarum Phyre2 PDB 4mnd chain A Region: 14 - 177 Aligned: 162 Modelled: 164 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:ctp l-myo-inositol-1-phosphate cytidylyltransferase/cdp-l- PDBTitle: crystal structure of archaeoglobus fulgidus ipct-dipps bifunctional2 membrane protein Phyre2 PDB 4o6m chain A Region: 14 - 186 Aligned: 159 Modelled: 159 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:af2299, a cdp-alcohol phosphotransferase; PDBTitle: structure of af2299, a cdp-alcohol phosphotransferase (cmp-bound) Phyre2 PDB 4k1c chain B Region: 22 - 209 Aligned: 186 Modelled: 188 Confidence: 48.8% Identity: 11% PDB header:membrane protein/metal transport Chain: B: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 4k1c chain A Region: 22 - 208 Aligned: 185 Modelled: 187 Confidence: 38.0% Identity: 11% PDB header:membrane protein/metal transport Chain: A: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 6mjb chain C Region: 60 - 77 Aligned: 18 Modelled: 18 Confidence: 28.6% Identity: 33% PDB header:cell cycle Chain: C: PDB Molecule:kinetochore-associated protein dsn1; PDBTitle: structure of candida glabrata csm1:dsn1(14-72) complex Phyre2 PDB 5guf chain A Region: 18 - 116 Aligned: 95 Modelled: 99 Confidence: 17.4% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:cdp-archaeol synthase; PDBTitle: structural insight into an intramembrane enzyme for archaeal membrane2 lipids biosynthesis Phyre2 PDB 2rkh chain A Region: 46 - 79 Aligned: 34 Modelled: 34 Confidence: 11.0% Identity: 29% PDB header:transcription Chain: A: PDB Molecule:putative apha-like transcription factor; PDBTitle: crystal structure of a putative apha-like transcription factor2 (zp_00208345.1) from magnetospirillum magnetotacticum ms-1 at 2.00 a3 resolution Phyre2 PDB 3eh4 chain A Region: 162 - 209 Aligned: 48 Modelled: 48 Confidence: 10.8% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c oxidase subunit 1; PDBTitle: structure of the reduced form of cytochrome ba3 oxidase from thermus2 thermophilus Phyre2 PDB 2voy chain G Region: 63 - 90 Aligned: 28 Modelled: 28 Confidence: 10.8% Identity: 21% PDB header:hydrolase Chain: G: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium atpase 1; PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 1xme chain A domain 1 Region: 162 - 209 Aligned: 48 Modelled: 48 Confidence: 9.5% Identity: 17% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 2le7 chain A Region: 57 - 70 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 43% PDB header:transport protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h member 2; PDBTitle: solution nmr structure of the s4s5 linker of herg potassium channel Phyre2 PDB 2n28 chain A Region: 163 - 209 Aligned: 47 Modelled: 47 Confidence: 7.2% Identity: 15% PDB header:viral protein Chain: A: PDB Molecule:protein vpu; PDBTitle: solid-state nmr structure of vpu Phyre2 PDB 4arp chain B Region: 46 - 75 Aligned: 30 Modelled: 30 Confidence: 5.6% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:pesticin; PDBTitle: structure of the inactive pesticin e178a mutant Phyre2 1 c6h59B_ 2 c5d92B_ 3 c4mndA_ 4 c4o6mA_ 5 c4k1cB_ 6 c4k1cA_ 7 c6mjbC_ 8 c5gufA_ 9 c2rkhA_ 10 c3eh4A_ 11 c2voyG_ 12 d1xmea1 13 c2le7A_ 14 c2n28A_ 15 c4arpB_