1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	A	L	A	F	T	I	L	A	V	L	L	A	G	P	T	P	A	L	L	A	R	A	T	W	P	L	R	A	P	R	A	A	M	V	L	W	Q	A	I	A	L	A	A	V	L	S	S	F	S	A	G	I	A	I	A	S	R	L
Secondary structure
SS confidence
Disorder		?	?																						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	M	P	G	P	D	G	R	P	T	T	S	F	V	G	A	A	G	R	L	G	W	P	L	W	A	A	Y	I	T	V	F	A	L	T	V	L	V	G	A	R	L	A	V	A	V	V	R	V	A	T	A	T	R	R	R	R	A	H	H
Secondary structure
SS confidence
Disorder		?	?								?						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	M	V	V	D	L	V	G	V	G	H	N	G	A	L	A	Q	P	C	A	R	A	R	D	L	R	V	L	D	V	A	Q	P	L	A	Y	C	L	P	G	V	R	S	R	V	V	V	S	E	G	T	L	T	A	L	A	D	A	E	V
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	I	L	T	H	E	R	A	H	L	R	A	R	H	D	L	V	L	E	A	F	T	A	V	H	A	A	F	P	R	L	V	R	S	A	N	A	L	G	A	V	Q	L	L	V	E	L	L	A	D	D	A	A	V	R	A	A	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	P	L	A	R	A	L	V	A	C	A	S	G	R	A	P	S	G	A	L	A	V	G	G	P	S	T	V	L	R	V	R	R	L	S	G	R	G	N	S	A	V	L	S	A	A	A	Y	L	A	A	A	A	V	L	V	V	P	T	V
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Sequence		A	L	A	V	P	W	L	T	Q	L	Q	R	L	F	I	A
Secondary structure
SS confidence
Disorder														?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 73%) Beta strand ( 3%) TM helix ( 26%) (View membrane topology prediction)

Rank Aligned region

PDB 4il3 chain B Region: 125 - 274 Aligned: 150 Modelled: 150 Confidence: 99.7% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:ste24p; PDBTitle: crystal structure of s. mikatae ste24p Phyre2 PDB 4aw6 chain B Region: 89 - 274 Aligned: 186 Modelled: 186 Confidence: 99.7% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:caax prenyl protease 1 homolog; PDBTitle: crystal structure of the human nuclear membrane zinc metalloprotease2 zmpste24 (face1) Phyre2 PDB 3c37 chain B Region: 145 - 274 Aligned: 118 Modelled: 129 Confidence: 99.4% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 3cqb chain B Region: 120 - 197 Aligned: 78 Modelled: 76 Confidence: 99.3% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 4jix chain B Region: 127 - 225 Aligned: 99 Modelled: 99 Confidence: 98.8% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:projannalysin; PDBTitle: crystal structure of the metallopeptidase zymogen of2 methanocaldococcus jannaschii jannalysin Phyre2 PDB 6ait chain D Region: 145 - 195 Aligned: 49 Modelled: 51 Confidence: 98.5% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:beta-barrel assembly-enhancing protease; PDBTitle: crystal structure of e. coli bepa Phyre2 PDB 4jiu chain A Region: 162 - 210 Aligned: 48 Modelled: 49 Confidence: 95.5% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:proabylysin; PDBTitle: crystal structure of the metallopeptidase zymogen of pyrococcus abyssi2 abylysin Phyre2 PDB 5xbv chain A Region: 175 - 227 Aligned: 38 Modelled: 38 Confidence: 94.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:wss1p; PDBTitle: crystal structure of wss1 mutant from saccharomyces cerevisiae Phyre2 PDB 6mdx chain A Region: 124 - 191 Aligned: 68 Modelled: 66 Confidence: 93.0% Identity: 16% PDB header:dna binding protein/dna Chain: A: PDB Molecule:sprt-like domain-containing protein spartan; PDBTitle: mechanism of protease dependent dpc repair Phyre2 PDB 3dtk chain A Region: 162 - 191 Aligned: 26 Modelled: 30 Confidence: 84.6% Identity: 15% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 5ln5 chain A Region: 175 - 196 Aligned: 22 Modelled: 22 Confidence: 84.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:ubiquitin and wlm domain-containing metalloprotease PDBTitle: crystal structure of the wss1 e203q mutant from s. pombe Phyre2 PDB 6cz6 chain D Region: 162 - 203 Aligned: 38 Modelled: 42 Confidence: 77.8% Identity: 13% PDB header:transcription Chain: D: PDB Molecule:hth-type transcriptional regulator prpr; PDBTitle: mycobacterium tuberculosis transcriptional regulator Phyre2 PDB 2ejq chain A domain 1 Region: 177 - 195 Aligned: 19 Modelled: 19 Confidence: 74.9% Identity: 47% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 3e11 chain A domain 1 Region: 177 - 196 Aligned: 20 Modelled: 20 Confidence: 61.8% Identity: 35% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 3qnf chain C Region: 176 - 190 Aligned: 15 Modelled: 15 Confidence: 50.7% Identity: 27% PDB header:hydrolase Chain: C: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 Phyre2 PDB 6h56 chain A Region: 179 - 191 Aligned: 13 Modelled: 13 Confidence: 50.3% Identity: 23% PDB header:metal binding protein Chain: A: PDB Molecule:effector domain of pseudomonas aeruginosa vgrg2b; PDBTitle: effector domain of pseudomonas aeruginosa vgrg2b Phyre2 PDB 1cxv chain A Region: 180 - 191 Aligned: 12 Modelled: 12 Confidence: 45.9% Identity: 25% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Matrix metalloproteases, catalytic domain Phyre2 PDB 4wz9 chain A Region: 177 - 190 Aligned: 14 Modelled: 14 Confidence: 45.6% Identity: 43% PDB header:hydrolase Chain: A: PDB Molecule:agap004809-pa; PDBTitle: apn1 from anopheles gambiae Phyre2 PDB 3qnf chain A Region: 177 - 190 Aligned: 14 Modelled: 14 Confidence: 45.5% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 Phyre2 PDB 2gtq chain A Region: 178 - 190 Aligned: 13 Modelled: 13 Confidence: 45.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis Phyre2 1 c4il3B_ 2 c4aw6B_ 3 c3c37B_ 4 c3cqbB_ 5 c4jixB_ 6 c6aitD_ 7 c4jiuA_ 8 c5xbvA_ 9 c6mdxA_ 10 c3dtkA_ 11 c5ln5A_ 12 c6cz6D_ 13 d2ejqa1 14 d3e11a1 15 c3qnfC_ 16 c6h56A_ 17 d1cxva_ 18 c4wz9A_ 19 c3qnfA_ 20 c2gtqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99