1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	T	N	N	D	A	W	D	L	A	T	S	V	G	A	T	A	T	M	V	A	A	A	R	A	V	A	T	R	A	D	N	P	L	I	D	D	P	F	A	E	P	L	V	R	A	V	G	I	D	F	F	T	R	W	A	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?	?																																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		N	I	K	A	T	D	V	D	D	P	D	G	T	W	G	L	Q	R	L	A	D	L	L	A	A	R	T	R	Y	F	D	A	F	F	R	D	A	T	S	A	G	I	R	Q	A	V	I	L	A	S	G	L	D	A	R	A	Y	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?		?			?																																					?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 58%) Beta strand ( 6%)

Rank Aligned region

PDB 2uyo chain A domain 1 Region: 15 - 118 Aligned: 94 Modelled: 104 Confidence: 100.0% Identity: 47% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: ML2640-like Phyre2 PDB 3iei chain D Region: 14 - 118 Aligned: 81 Modelled: 83 Confidence: 99.4% Identity: 20% PDB header:transferase Chain: D: PDB Molecule:leucine carboxyl methyltransferase 1; PDBTitle: crystal structure of human leucine carboxylmethyltransferase-1 in2 complex with s-adenosyl homocysteine Phyre2 PDB 3mnt chain A Region: 37 - 118 Aligned: 60 Modelled: 60 Confidence: 99.3% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:leucine carboxyl methyltransferase 1; PDBTitle: crystal structure of human leucine carboxyl methyltransferase 1 Phyre2 PDB 1rjd chain A Region: 15 - 118 Aligned: 101 Modelled: 104 Confidence: 99.3% Identity: 16% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Leucine carboxy methyltransferase Ppm1 Phyre2 PDB 2zwa chain A Region: 31 - 118 Aligned: 65 Modelled: 65 Confidence: 98.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:leucine carboxyl methyltransferase 2; PDBTitle: crystal structure of trna wybutosine synthesizing enzyme2 tyw4 Phyre2 PDB 2qe6 chain B Region: 77 - 117 Aligned: 41 Modelled: 41 Confidence: 92.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:uncharacterized protein tfu_2867; PDBTitle: crystal structure of a putative methyltransferase (tfu_2867) from2 thermobifida fusca yx at 1.95 a resolution Phyre2 PDB 5fwa chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 60.2% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 2; PDBTitle: crystal structure of mus musculus protein arginine methyltransferase 22 with cp1 Phyre2 PDB 1f3l chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 58.6% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Arginine methyltransferase Phyre2 PDB 4y30 chain B Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 56.3% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:protein arginine n-methyltransferase 6; PDBTitle: crystal structure of human protein arginine methyltransferase prmt62 bound to sah and epz020411 Phyre2 PDB 5lkj chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 53.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:histone-arginine methyltransferase carm1; PDBTitle: crystal structure of mouse carm1 in complex with ligand sa684 Phyre2 PDB 1g6q chain 1 Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 52.8% Identity: 15% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Arginine methyltransferase Phyre2 PDB 2v7e chain B Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 49.7% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:histone-arginine methyltransferase carm1; PDBTitle: crystal structure of coactivator-associated arginine2 methyltransferase 1 (carm1), unliganded Phyre2 PDB 1ori chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 48.6% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Arginine methyltransferase Phyre2 PDB 2fyt chain A domain 1 Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 48.4% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Arginine methyltransferase Phyre2 PDB 3b3j chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 47.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:histone-arginine methyltransferase carm1; PDBTitle: the 2.55 a crystal structure of the apo catalytic domain of2 coactivator-associated arginine methyl transferase i(carm1:28-507,3 residues 28-146 and 479-507 not ordered) Phyre2 PDB 1orh chain A Region: 85 - 112 Aligned: 28 Modelled: 28 Confidence: 46.2% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 1; PDBTitle: structure of the predominant protein arginine methyltransferase prmt1 Phyre2 PDB 3giw chain A Region: 77 - 114 Aligned: 38 Modelled: 38 Confidence: 45.1% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:protein of unknown function duf574; PDBTitle: crystal structure of a duf574 family protein (sav_2177) from2 streptomyces avermitilis ma-4680 at 1.45 a resolution Phyre2 PDB 5fub chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 44.1% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:protein arginine methyltransferase 2; PDBTitle: crystal structure of zebrafish protein arginine methyltransferase 22 catalytic domain with sah Phyre2 PDB 4hc4 chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 43.2% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 6; PDBTitle: human hmt1 hnrnp methyltransferase-like protein 6 (s. cerevisiae) Phyre2 PDB 6dnz chain A Region: 85 - 111 Aligned: 27 Modelled: 27 Confidence: 42.2% Identity: 15% PDB header:gene regulation Chain: A: PDB Molecule:arginine n-methyltransferase, putative; PDBTitle: trypanosoma brucei prmt1 enzyme-prozyme heterotetrameric complex with2 adohcy Phyre2 1 d2uyoa1 2 c3ieiD_ 3 c3mntA_ 4 d1rjda_ 5 c2zwaA_ 6 c2qe6B_ 7 c5fwaA_ 8 d1f3la_ 9 c4y30B_ 10 c5lkjA_ 11 d1g6q1_ 12 c2v7eB_ 13 d1oria_ 14 d2fyta1 15 c3b3jA_ 16 c1orhA_ 17 c3giwA_ 18 c5fubA_ 19 c4hc4A_ 20 c6dnzA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99