1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	M	C	E	G	R	P	T	E	S	P	I	P	R	W	L	R	F	V	L	T	S	D	R	A	G	S	A	W	Y	I	G	A	G	F	F	F	A	P	V	L	A	V	L	S	P	W	P	T	I	T	A	V	L	W	W	I	I	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.
Sequence		L	A	G	L	W	L	G	L	L	G	I	A	M	A	V	G	L	A	R	V	L	R	S	G	A	E	I	P	E	A	Y	W	R	T	L	V	D	Y	R	S	A	N	E
Secondary structure
SS confidence
Disorder																							?																?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 46%) (View membrane topology prediction)

Rank Aligned region

PDB 2wvr chain B Region: 81 - 99 Aligned: 19 Modelled: 19 Confidence: 33.0% Identity: 21% PDB header:replication Chain: B: PDB Molecule:geminin; PDBTitle: human cdt1:geminin complex Phyre2 PDB 2h8p chain C domain 1 Region: 85 - 96 Aligned: 12 Modelled: 12 Confidence: 16.9% Identity: 25% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 5z58 chain W Region: 12 - 17 Aligned: 6 Modelled: 6 Confidence: 15.8% Identity: 67% PDB header:splicing Chain: W: PDB Molecule: PDBTitle: cryo-em structure of a human activated spliceosome (early bact) at 4.92 angstrom. Phyre2 PDB 5oqt chain C Region: 66 - 84 Aligned: 18 Modelled: 19 Confidence: 13.5% Identity: 50% PDB header:transport protein Chain: C: PDB Molecule:uncharacterized protein ynem; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue Phyre2 PDB 1hk7 chain A Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 13.4% Identity: 58% PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp82; PDBTitle: middle domain of hsp90 Phyre2 PDB 6g90 chain T Region: 12 - 17 Aligned: 6 Modelled: 6 Confidence: 13.2% Identity: 50% PDB header:splicing Chain: T: PDB Molecule:pre-mrna-splicing factor prp9; PDBTitle: prespliceosome structure provides insight into spliceosome assembly2 and regulation (map a2) Phyre2 PDB 1y6z chain A Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 13.2% Identity: 50% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:heat shock protein, putative; PDBTitle: middle domain of plasmodium falciparum putative heat shock protein2 pf14_0417 Phyre2 PDB 5jyg chain A Region: 72 - 95 Aligned: 21 Modelled: 24 Confidence: 13.1% Identity: 43% PDB header:structural protein Chain: A: PDB Molecule:actin-like atpase; PDBTitle: cryo-em structure of the mamk filament at 6.5 a Phyre2 PDB 6f34 chain C Region: 66 - 84 Aligned: 18 Modelled: 19 Confidence: 12.4% Identity: 50% PDB header:membrane protein Chain: C: PDB Molecule:mgts; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue bound to arginine. Phyre2 PDB 2qw6 chain A Region: 77 - 96 Aligned: 18 Modelled: 20 Confidence: 12.1% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:aaa atpase, central region; PDBTitle: crystal structure of the c-terminal domain of an aaa atpase from2 enterococcus faecium do Phyre2 PDB 2qw6 chain A domain 1 Region: 77 - 96 Aligned: 18 Modelled: 20 Confidence: 12.1% Identity: 33% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: MgsA/YrvN C-terminal domain-like Phyre2 PDB 1usu chain A Region: 7 - 20 Aligned: 14 Modelled: 14 Confidence: 11.6% Identity: 50% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Hsp90 middle domain Phyre2 PDB 2ww9 chain O Region: 12 - 19 Aligned: 8 Modelled: 8 Confidence: 11.5% Identity: 50% PDB header:ribosome Chain: O: PDB Molecule:60s ribosomal protein l39; PDBTitle: cryo-em structure of the active yeast ssh1 complex bound to the yeast2 80s ribosome Phyre2 PDB 2o1t chain B Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 11.4% Identity: 33% PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of middle plus c-terminal domains (m+c) of grp94 Phyre2 PDB 1dxs chain A Region: 86 - 98 Aligned: 13 Modelled: 13 Confidence: 11.1% Identity: 62% Fold: SAM domain-like Superfamily: SAM/Pointed domain Family: SAM (sterile alpha motif) domain Phyre2 PDB 4xb6 chain D Region: 11 - 35 Aligned: 23 Modelled: 25 Confidence: 10.7% Identity: 35% PDB header:transferase Chain: D: PDB Molecule:alpha-d-ribose 1-methylphosphonate 5-phosphate c-p lyase; PDBTitle: structure of the e. coli c-p lyase core complex Phyre2 PDB 3pry chain A Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 9.8% Identity: 33% PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-beta; PDBTitle: crystal structure of the middle domain of human hsp90-beta refined at2 2.3 a resolution Phyre2 PDB 2xuv chain B Region: 45 - 59 Aligned: 13 Modelled: 15 Confidence: 9.7% Identity: 54% PDB header:unknown function Chain: B: PDB Molecule:hdeb; PDBTitle: the structure of hdeb Phyre2 PDB 1rg6 chain A Region: 81 - 103 Aligned: 23 Modelled: 23 Confidence: 9.5% Identity: 26% Fold: SAM domain-like Superfamily: SAM/Pointed domain Family: SAM (sterile alpha motif) domain Phyre2 PDB 2zkr chain 3 Region: 12 - 19 Aligned: 8 Modelled: 8 Confidence: 9.3% Identity: 63% PDB header:ribosomal protein/rna Chain: 3: PDB Molecule:60s ribosomal protein l39e; PDBTitle: structure of a mammalian ribosomal 60s subunit within an 80s complex2 obtained by docking homology models of the rna and proteins into an3 8.7 a cryo-em map Phyre2 1 c2wvrB_ 2 d2h8pc1 3 c5z58w_ 4 c5oqtC_ 5 c1hk7A_ 6 c6g90T_ 7 c1y6zA_ 8 c5jygA_ 9 c6f34C_ 10 c2qw6A_ 11 d2qw6a1 12 d1usua_ 13 c2ww9O_ 14 c2o1tB_ 15 d1dxsa_ 16 c4xb6D_ 17 c3pryA_ 18 c2xuvB_ 19 d1rg6a_ 20 c2zkr3_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40