1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	E	Q	H	P	P	I	T	E	T	T	T	G	A	A	S	N	G	C	P	V	V	G	H	M	K	Y	P	V	E	G	G	G	N	Q	D	W	W	P	N	R	L	N	L	K	V	L	H	Q	N	P	A	V	A	D	P	M	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	F	D	Y	A	A	E	V	A	T	I	D	V	D	A	L	T	R	D	I	E	E	V	M	T	T	S	Q	P	W	W	P	A	D	Y	G	H	Y	G	P	L	F	I	R	M	A	W	H	A	A	G	T	Y	R	I	H	D	G	R	G
Secondary structure
SS confidence
Disorder																															?																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	G	G	G	M	Q	R	F	A	P	L	N	S	W	P	D	N	A	S	L	D	K	A	R	R	L	L	W	P	V	K	K	K	Y	G	K	K	L	S	W	A	D	L	I	V	F	A	G	N	C	A	L	E	S	M	G	F	K	T
Secondary structure
SS confidence
Disorder										?				?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	G	F	G	F	G	R	V	D	Q	W	E	P	D	E	V	Y	W	G	K	E	A	T	W	L	G	D	E	R	Y	S	G	K	R	D	L	E	N	P	L	A	A	V	Q	M	G	L	I	Y	V	N	P	E	G	P	N	G	N	P	D
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	M	A	A	A	V	D	I	R	E	T	F	R	R	M	A	M	N	D	V	E	T	A	A	L	I	V	G	G	H	T	F	G	K	T	H	G	A	G	P	A	D	L	V	G	P	E	P	E	A	A	P	L	E	Q	M	G	L	G	W
Secondary structure
SS confidence
Disorder		?	?	?	?																																				?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	S	S	Y	G	T	G	T	G	K	D	A	I	T	S	G	I	E	V	V	W	T	N	T	P	T	K	W	D	N	S	F	L	E	I	L	Y	G	Y	E	W	E	L	T	K	S	P	A	G	A	W	Q	Y	T	A	K	D	G	A	G
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																?	?	?	?	?	?	?	?	?	?	?	?						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	G	T	I	P	D	P	F	G	G	P	G	R	S	P	T	M	L	A	T	D	L	S	L	R	V	D	P	I	Y	E	R	I	T	R	R	W	L	E	H	P	E	E	L	A	D	E	F	A	K	A	W	Y	K	L	I	H	R	D	M
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?	?	?	?	?	?	?					?			?				?																																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	P	V	A	R	Y	L	G	P	L	V	P	K	Q	T	L	L	W	Q	D	P	V	P	A	V	S	H	D	L	V	G	E	A	E	I	A	S	L	K	S	Q	I	R	A	S	G	L	T	V	S	Q	L	V	S	T	A	W	A	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		S	S	F	R	G	S	D	K	R	G	G	A	N	G	G	R	I	R	L	Q	P	Q	V	G	W	E	V	N	D	P	D	G	D	L	R	K	V	I	R	T	L	E	E	I	Q	E	S	F	N	S	A	A	P	G	N	I	K	V	S	F
Secondary structure
SS confidence
Disorder						?	?	?	?		?	?	?							?				?	?	?	?	?	?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		A	D	L	V	V	L	G	G	C	A	A	I	E	K	A	A	K	A	A	G	H	N	I	T	V	P	F	T	P	G	R	T	D	A	S	Q	E	Q	T	D	V	E	S	F	A	V	L	E	P	K	A	D	G	F	R	N	Y	L	G	K
Secondary structure
SS confidence
Disorder																				?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?		?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		G	N	P	L	P	A	E	Y	M	L	L	D	K	A	N	L	L	T	L	S	A	P	E	M	T	V	L	V	G	G	L	R	V	L	G	A	N	Y	K	R	L	P	L	G	V	F	T	E	A	S	E	S	L	T	N	D	F	F	V	N
Secondary structure
SS confidence
Disorder		?	?																										?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		L	L	D	M	G	I	T	W	E	P	S	P	A	D	D	G	T	Y	Q	G	K	D	G	S	G	K	V	K	W	T	G	S	R	V	D	L	V	F	G	S	N	S	E	L	R	A	L	V	E	V	Y	G	A	D	D	A	Q	P	K	F
Secondary structure
SS confidence
Disorder									?					?	?	?	?				?	?	?	?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740
Sequence		V	Q	D	F	V	A	A	W	D	K	V	M	N	L	D	R	F	D	V	R
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 36%) Alpha helix ( 38%) Beta strand ( 1%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 2cca chain A Region: 19 - 740 Aligned: 714 Modelled: 722 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:peroxidase/catalase t; PDBTitle: crystal structure of the catalase-peroxidase (katg) and2 s315t mutant from mycobacterium tuberculosis Phyre2 PDB 3ut2 chain B Region: 18 - 739 Aligned: 716 Modelled: 722 Confidence: 100.0% Identity: 57% PDB header:oxidoreductase Chain: B: PDB Molecule:catalase-peroxidase 2; PDBTitle: crystal structure of fungal magkatg2 Phyre2 PDB 1itk chain B Region: 30 - 740 Aligned: 710 Modelled: 711 Confidence: 100.0% Identity: 57% PDB header:oxidoreductase Chain: B: PDB Molecule:catalase-peroxidase; PDBTitle: crystal structure of catalase-peroxidase from haloarcula2 marismortui Phyre2 PDB 2b2q chain B Region: 32 - 739 Aligned: 706 Modelled: 708 Confidence: 100.0% Identity: 68% PDB header:oxidoreductase Chain: B: PDB Molecule:catalase-peroxidase; PDBTitle: crystal structure of native catalase-peroxidase katg at ph7.5 Phyre2 PDB 2fxh chain B Region: 32 - 739 Aligned: 706 Modelled: 708 Confidence: 100.0% Identity: 68% PDB header:oxidoreductase Chain: B: PDB Molecule:catalase-peroxidase protein; PDBTitle: crystal structure of katg at ph 6.5 Phyre2 PDB 5whq chain A Region: 25 - 739 Aligned: 707 Modelled: 715 Confidence: 100.0% Identity: 58% PDB header:oxidoreductase Chain: A: PDB Molecule:catalase-peroxidase; PDBTitle: crystal structure of the catalase-peroxidase from neurospora crassa at2 2.9 a Phyre2 PDB 1ub2 chain A Region: 34 - 739 Aligned: 689 Modelled: 706 Confidence: 100.0% Identity: 55% PDB header:oxidoreductase Chain: A: PDB Molecule:catalase-peroxidase; PDBTitle: crystal structure of catalase-peroxidase from synechococcus pcc 7942 Phyre2 PDB 3vlm chain B Region: 41 - 737 Aligned: 657 Modelled: 661 Confidence: 100.0% Identity: 59% PDB header:oxidoreductase Chain: B: PDB Molecule:catalase-peroxidase 2; PDBTitle: crystal structure analysis of the met244ala variant of katg from2 haloarcula marismortui Phyre2 PDB 2cca chain A domain 1 Region: 26 - 435 Aligned: 410 Modelled: 410 Confidence: 100.0% Identity: 100% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1mwv chain A domain 1 Region: 32 - 432 Aligned: 400 Modelled: 401 Confidence: 100.0% Identity: 68% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1ub2 chain A domain 1 Region: 34 - 432 Aligned: 398 Modelled: 399 Confidence: 100.0% Identity: 58% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1itk chain A domain 1 Region: 30 - 432 Aligned: 396 Modelled: 403 Confidence: 100.0% Identity: 59% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1mwv chain A domain 2 Region: 433 - 739 Aligned: 306 Modelled: 307 Confidence: 100.0% Identity: 67% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1itk chain A domain 2 Region: 433 - 740 Aligned: 306 Modelled: 308 Confidence: 100.0% Identity: 54% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 2cca chain A domain 2 Region: 436 - 720 Aligned: 285 Modelled: 285 Confidence: 100.0% Identity: 100% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1ub2 chain A domain 2 Region: 433 - 739 Aligned: 291 Modelled: 307 Confidence: 100.0% Identity: 52% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 1u2j chain C Region: 436 - 739 Aligned: 277 Modelled: 281 Confidence: 100.0% Identity: 53% PDB header:oxidoreductase Chain: C: PDB Molecule:peroxidase/catalase hpi; PDBTitle: crystal structure of the c-terminal domain from the2 catalase-peroxidase katg of escherichia coli (p21 21 21) Phyre2 PDB 1u2k chain A Region: 439 - 739 Aligned: 274 Modelled: 285 Confidence: 100.0% Identity: 53% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: Catalase-peroxidase KatG Phyre2 PDB 2eut chain A domain 1 Region: 72 - 420 Aligned: 257 Modelled: 263 Confidence: 100.0% Identity: 33% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: CCP-like Phyre2 PDB 1iyn chain A Region: 72 - 420 Aligned: 254 Modelled: 265 Confidence: 100.0% Identity: 32% Fold: Heme-dependent peroxidases Superfamily: Heme-dependent peroxidases Family: CCP-like Phyre2 1 c2ccaA_ 2 c3ut2B_ 3 c1itkB_ 4 c2b2qB_ 5 c2fxhB_ 6 c5whqA_ 7 c1ub2A_ 8 c3vlmB_ 9 d2ccaa1 10 d1mwva1 11 d1ub2a1 12 d1itka1 13 d1mwva2 14 d1itka2 15 d2ccaa2 16 d1ub2a2 17 c1u2jC_ 18 d1u2ka_ 19 d2euta1 20 d1iyna_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99