Phyre 2 Results for RVBD1917c_(PPE34)_2162939

Email	mdejesus@rockefeller.edu
Description	RVBD1917c_(PPE34)_2162939_2167318
Date	Fri Aug 2 13:30:53 BST 2019
Unique Job ID	7eda22ad27de1089
Sequence	MNFSTLPPEI ... Download FASTA
Job Type	normal
Job Expiry

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:60.074 Y:72.050 Z:72.893

Model (left) based on template c5xfsB_

Top template information

PDB header:protein transport
Chain: B: PDB Molecule:ppe family protein ppe15;
PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis

Confidence and coverage

Confidence:

100.0%

Coverage:

12%

172 residues ( 12% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Warning: 79% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in JSmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Download FASTA version

Secondary structure and disorder prediction [Show]

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M N F S T L P P E I N S A L I F G G A G S E P M S A A A V A W D Q L A M E L A S A A A S F N S V T S G L V G E S W L G P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence S S A A M A A A V A P Y L G W L A A A A A Q A Q R S A T Q A A A L V A E F E A V R A A M V Q P A L V A A N R S D L V S L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence V F S N F F G Q N A P A I A A I E A A Y E Q M W A I D V S V M S A Y H A G A S A V A S A L T P F T A P P Q N L T D L P A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence Q L A A A P A A V V T A A I T S S K G V L A N L S L G L A N S G F G Q M G A A N L G I L N L G S L N P G G N N F G L G N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence V G S N N V G L G N T G N G N I G F G N T G N G N I G F G L T G D N Q Q G F G G W N S G T G N I G L F N S G T G N I G I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence G N T G T G N F G I G N S G T S Y N T G I G N T G Q A N T G F F N A G I A N T G I G N T G N Y N T G S F N L G S F N T G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence D F N T G S S N T G F F N P G N L N T G V G N T G N V N T G G F N S G N Y S N G F F W R G D Y Q G L I G F S G T L T I P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A A G L D L N G L G S V G P I T I P S I T I P E I G L G I N S S G A L V G P I N V P P I T V P A I G L G I N S T G A L V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence G P I N I P P I T L N S I G L E L S A F Q V I N V G S I S I P A S P L A I G L F G V N P T V G S I G P G S I S I Q L G T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence P E I P A I P P F F P G F P P D Y V T V S G Q I G P I T F L S G G Y S L P A I P L G I D V G G G L G P F T V F P D G Y S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence L P A I P L G I D V G G G L G P F T V F P D G Y S L P A I P L G I D V G G G L G P F T V F P D G Y S L P A I P L G I D V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence G G A I G P L T T P P I T I P S I P L G I D V S G S L G P I N I P I E I A G T P G F G N S T T T P S S G F F N S G T G G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence T S G F G N V G S G G S G F W N I A G N L G N S G F L N V G P L T S G I L N F G N T V S G L Y N T S T L G L A T S A F H

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence S G V G N T D S Q L A G F M R N A A G G T L F N F G F A N D G T L N L G N A N L G D Y N V G S G N V G S Y N F G S G N I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence G N G S F G F G N I G S N N F G F G N V G S N N L G F A N T G P G L T E A L H N I G F G N I G G N N Y G F A N I G N G N

Secondary structure

SS confidence

Disorder ? ?
? ? ? ? ?
?
?
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence I G F G N T G T G N I G I G L T G D N Q V G F G A L N S G S G N I G F F N S G N G N I G F F N S G N G N V G I G N S G N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence Y N T G L G N V G N A N T G L F N T G N V N T G I G N A G S Y N T G S Y N A G D T N T G D L N P G N A N T G Y L N L G D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence L N T G W G N I G D L N T G A L I S G S Y S N G I L W R G D Y Q G L I G Y S D T L S I P A I P L S V E V N G G I G P I V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence V P D I T I P G I P L S L N A L G G V G P I V V P D I T I P G I P L S L N A L G G V G P I V V P D I T I P G I P L S L N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence A L G G V G P I V V P D I T I P G I P L S L N A L G G V G P I V V P D I T I P G I P L S L N A L G G V G P I T V P G V P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence I S R I P L T I N I R I P V N I T L N E L P F N V A G I F T G Y I G P I P L S T F V L G V T L A G G T L E S G I Q G F S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?
? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence V N P F G L N I P L S G A T N A V T I P G F A I N P F G L N V P L S G G T S P V T I P G F A I N P F G L N V P L S G G T

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
?
?
? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence S P V T I P G F T I P G S P L N L T A N G G L G P I N I P I N I T S A P G F G N S T T T P S S G F F N S G D G S A S G F

Secondary structure

SS confidence

Disorder
?
? ? ?
? ? ? ? ?
? ? ? ? ?
?
? ? ?
?
? ? ?
? ?
? ?
?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence G N V G P G I S G L W N Q V P N A L Q G G V S G I Y N V G Q L A S G V A N L G N T V S G F N N T S T V G H L T A A F N S

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ?
? ?
? ? ?
?
? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . .

Sequence G V N N I G Q M L L G F F S P G A G P

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 79%)

Alpha helix ( 10%)

Beta strand ( 4%)

TM helix ( 1%)
(View membrane topology prediction)

Domain analysis [Show]

Rank Aligned region

PDB 5xfs chain B

3D model

Region: 1 - 173
Aligned: 172
Modelled: 173
Confidence: 100.0%
Identity: 51%
PDB header:protein transport
Chain: B: PDB Molecule:ppe family protein ppe15;
PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis

Phyre2

PDB 2g38 chain B

3D model

Region: 2 - 173
Aligned: 171
Modelled: 172
Confidence: 100.0%
Identity: 34%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:ppe family protein;
PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis

Phyre2

PDB 2g38 chain B domain 1

3D model

Region: 2 - 173
Aligned: 171
Modelled: 172
Confidence: 100.0%
Identity: 34%
Fold: Ferritin-like
Superfamily: PE/PPE dimer-like
Family: PPE

Phyre2

PDB 4xy3 chain A

Region: 5 - 173
Aligned: 152
Modelled: 160
Confidence: 100.0%
Identity: 19%
PDB header:protein transport
Chain: A: PDB Molecule:esx-1 secretion-associated protein espb;
PDBTitle: structure of esx-1 secreted protein espb

Phyre2

PDB 4wj2 chain A

3D model

Region: 19 - 181
Aligned: 140
Modelled: 155
Confidence: 96.7%
Identity: 21%
PDB header:unknown function
Chain: A: PDB Molecule:antigen mtb48;
PDBTitle: mycobacterial protein

Phyre2

PDB 4iog chain D

Region: 21 - 98
Aligned: 77
Modelled: 78
Confidence: 95.7%
Identity: 16%
PDB header:unknown function
Chain: D: PDB Molecule:secreted protein esxb;
PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne

Phyre2

PDB 2vs0 chain B

3D model

Region: 21 - 100
Aligned: 79
Modelled: 80
Confidence: 95.5%
Identity: 9%
PDB header:cell invasion
Chain: B: PDB Molecule:virulence factor esxa;
PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa

Phyre2

PDB 3gvm chain A

3D model

Region: 21 - 100
Aligned: 79
Modelled: 80
Confidence: 94.4%
Identity: 11%
PDB header:viral protein
Chain: A: PDB Molecule:putative uncharacterized protein sag1039;
PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae

Phyre2

PDB 3zbh chain C

3D model

Region: 21 - 100
Aligned: 79
Modelled: 80
Confidence: 94.2%
Identity: 16%
PDB header:unknown function
Chain: C: PDB Molecule:esxa;
PDBTitle: geobacillus thermodenitrificans esxa crystal form i

Phyre2

PDB 1wa8 chain A domain 1

Region: 21 - 100
Aligned: 79
Modelled: 80
Confidence: 92.4%
Identity: 15%
Fold: Ferritin-like
Superfamily: EsxAB dimer-like
Family: ESAT-6 like

Phyre2

PDB 3jyw chain F

3D model

Region: 60 - 105
Aligned: 46
Modelled: 43
Confidence: 69.2%
Identity: 43%
PDB header:ribosome
Chain: F: PDB Molecule:60s ribosomal protein l7(a);
PDBTitle: structure of the 60s proteins for eukaryotic ribosome based on cryo-em2 map of thermomyces lanuginosus ribosome at 8.9a resolution

Phyre2

PDB 4lws chain A

3D model

Region: 24 - 101
Aligned: 77
Modelled: 77
Confidence: 65.7%
Identity: 19%
PDB header:unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata

Phyre2

PDB 1wa8 chain B domain 1

3D model

Region: 24 - 100
Aligned: 76
Modelled: 77
Confidence: 58.8%
Identity: 16%
Fold: Ferritin-like
Superfamily: EsxAB dimer-like
Family: ESAT-6 like

Phyre2

PDB 4i0x chain A

Region: 26 - 68
Aligned: 42
Modelled: 43
Confidence: 47.6%
Identity: 19%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:esat-6-like protein mab_3112;
PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex

Phyre2

PDB 2vsn chain B

3D model

Region: 98 - 146
Aligned: 49
Modelled: 49
Confidence: 45.7%
Identity: 12%
PDB header:transferase
Chain: B: PDB Molecule:xcogt;
PDBTitle: structure and topological arrangement of an o-glcnac2 transferase homolog: insight into molecular control of3 intracellular glycosylation

Phyre2

PDB 4lws chain B

3D model

Region: 24 - 98
Aligned: 74
Modelled: 75
Confidence: 37.8%
Identity: 9%
PDB header:unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata

Phyre2

PDB 2kg7 chain B

3D model

Region: 21 - 100
Aligned: 79
Modelled: 80
Confidence: 31.5%
Identity: 16%
PDB header:unknown function
Chain: B: PDB Molecule:esat-6-like protein esxh;
PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288

Phyre2

PDB 4bgo chain A

3D model

Region: 59 - 156
Aligned: 83
Modelled: 98
Confidence: 29.0%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:efem m75 peptidase;
PDBTitle: structural and functional role of the imelysin-like protein2 efem from pseudomonas syringae pv. syringae and3 implications in bacterial iron transport

Phyre2

PDB 5djs chain A

3D model

Region: 90 - 144
Aligned: 55
Modelled: 55
Confidence: 24.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:tetratricopeptide tpr_2 repeat protein;
PDBTitle: thermobaculum terrenum o-glcnac transferase mutant - k341m

Phyre2

PDB 5uz9 chain B

3D model

Region: 107 - 156
Aligned: 47
Modelled: 50
Confidence: 21.5%
Identity: 21%
PDB header:immune system/rna
Chain: B: PDB Molecule:crispr-associated protein csy2;
PDBTitle: cryo em structure of anti-crisprs, acrf1 and acrf2, bound to type i-f2 crrna-guided crispr surveillance complex

Phyre2

1
c5xfsB_

2
c2g38B_

3
d2g38b1

4
c4xy3A_

5
c4wj2A_

6
c4iogD_

7
c2vs0B_

8
c3gvmA_

9
c3zbhC_

10
d1wa8a1

11
c3jywF_

12
c4lwsA_

13
d1wa8b1

14
c4i0xA_

15
c2vsnB_

16
c4lwsB_

17
c2kg7B_

18
c4bgoA_

19
c5djsA_

20
c5uz9B_

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