1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	A	I	P	G	P	S	G	A	E	P	G	E	S	R	A	L	A	G	Y	P	V	T	P	P	A	L	P	R	P	V	I	F	D	Q	R	W	T	D	L	T	F	I	H	W	P	V	L	P	E	S	V	A	G	S	Y	P	P	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	R	P	D	V	F	A	D	G	M	T	Y	V	G	L	V	P	F	R	M	S	S	T	K	L	G	T	A	L	P	I	P	Y	V	G	T	F	P	E	T	N	V	R	L	Y	S	I	D	N	A	G	R	H	G	V	L	F	R	S	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	T	A	R	L	T	V	V	P	L	T	R	I	G	L	G	I	P	Y	A	W	S	R	M	R	M	M	R	S	G	K	H	I	T	Y	H	S	V	R	R	W	P	R	R	G	L	R	S	L	L	T	I	T	I	G	D	L	V	E	P
Secondary structure
SS confidence
Disorder																												?		?																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	P	L	E	V	W	L	T	A	R	W	G	A	H	T	R	K	A	G	R	T	W	W	V	P	N	E	H	K	P	W	P	L	R	A	A	E	I	A	E	L	N	D	E	L	I	D	A	S	G	V	Q	P	T	G	D	R	L	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.
Sequence		L	F	S	P	G	V	H	A	R	F	G	R	P	C	V	V	Q
Secondary structure
SS confidence
Disorder													?	?	?		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 11%) Beta strand ( 47%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3bgt chain D Region: 21 - 160 Aligned: 124 Modelled: 139 Confidence: 99.7% Identity: 16% PDB header:lyase Chain: D: PDB Molecule:probable acetoacetate decarboxylase; PDBTitle: structural studies of acetoacetate decarboxylase Phyre2 PDB 3bh2 chain C Region: 13 - 160 Aligned: 133 Modelled: 139 Confidence: 99.6% Identity: 12% PDB header:lyase Chain: C: PDB Molecule:acetoacetate decarboxylase; PDBTitle: structural studies of acetoacetate decarboxylase Phyre2 PDB 4jme chain A Region: 18 - 252 Aligned: 226 Modelled: 235 Confidence: 99.4% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein mppr; PDBTitle: enduracididine biosynthesis enzyme mppr complexed with 2-keto-2 enduracididine Phyre2 PDB 3c8w chain A domain 1 Region: 8 - 160 Aligned: 137 Modelled: 143 Confidence: 99.0% Identity: 13% Fold: Acetoacetate decarboxylase-like Superfamily: Acetoacetate decarboxylase-like Family: Acetoacetate decarboxylase-like Phyre2 PDB 4zbt chain B Region: 21 - 160 Aligned: 134 Modelled: 140 Confidence: 99.0% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:acetoacetate decarboxylase; PDBTitle: streptomyces bingchenggensis aldolase-dehydratase in schiff base2 complex with pyruvate Phyre2 PDB 5upb chain A Region: 11 - 159 Aligned: 134 Modelled: 149 Confidence: 98.9% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:acetoacetate decarboxylase; PDBTitle: swit_4259, an acetoacetate decarboxylase-like enzyme from sphingomonas2 wittichii rw1 Phyre2 PDB 3cmb chain A domain 1 Region: 21 - 159 Aligned: 127 Modelled: 138 Confidence: 98.6% Identity: 13% Fold: Acetoacetate decarboxylase-like Superfamily: Acetoacetate decarboxylase-like Family: Acetoacetate decarboxylase-like Phyre2 PDB 5jxp chain A Region: 62 - 116 Aligned: 53 Modelled: 55 Confidence: 19.6% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:asp/glu-specific dipeptidyl-peptidase; PDBTitle: crystal structure of porphyromonas endodontalis dpp11 in alternate2 conformation Phyre2 PDB 1s1d chain A Region: 223 - 254 Aligned: 32 Modelled: 31 Confidence: 14.0% Identity: 31% Fold: 5-bladed beta-propeller Superfamily: Apyrase Family: Apyrase Phyre2 PDB 2yue chain A Region: 48 - 130 Aligned: 76 Modelled: 83 Confidence: 12.6% Identity: 17% PDB header:rna binding protein Chain: A: PDB Molecule:protein neuralized; PDBTitle: solution structure of the neuz (nhr) domain in neuralized2 from drosophila melanogaster Phyre2 PDB 1ttz chain A Region: 44 - 57 Aligned: 14 Modelled: 14 Confidence: 10.7% Identity: 14% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Thioltransferase Phyre2 PDB 3wol chain B Region: 62 - 116 Aligned: 53 Modelled: 55 Confidence: 10.3% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:dipeptidyl aminopeptidase bii; PDBTitle: crystal structure of the dap bii dipeptide complex i Phyre2 PDB 5w6l chain A Region: 68 - 112 Aligned: 43 Modelled: 45 Confidence: 9.5% Identity: 12% PDB header:toxin Chain: A: PDB Molecule:rtx repeat-containing cytotoxin; PDBTitle: crystal structure of rrsp, a martx toxin effector domain from vibrio2 vulnificus cmcp6 Phyre2 PDB 3jb9 chain K Region: 207 - 216 Aligned: 10 Modelled: 10 Confidence: 7.5% Identity: 40% PDB header:rna binding protein/rna Chain: K: PDB Molecule:pre-mrna-splicing factor prp5; PDBTitle: cryo-em structure of the yeast spliceosome at 3.6 angstrom resolution Phyre2 PDB 2j58 chain G Region: 101 - 178 Aligned: 78 Modelled: 78 Confidence: 7.3% Identity: 13% PDB header:membrane protein Chain: G: PDB Molecule:outer membrane lipoprotein wza; PDBTitle: the structure of wza Phyre2 PDB 5ijl chain A Region: 131 - 156 Aligned: 26 Modelled: 26 Confidence: 6.8% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:dna polymerase ii large subunit; PDBTitle: d-family dna polymerase - dp2 subunit (catalytic subunit) Phyre2 PDB 3fxt chain B Region: 110 - 143 Aligned: 32 Modelled: 34 Confidence: 5.7% Identity: 16% PDB header:gene regulation Chain: B: PDB Molecule:nucleoside diphosphate-linked moiety x motif 6; PDBTitle: crystal structure of the n-terminal domain of human nudt6 Phyre2 PDB 2b5d chain X domain 1 Region: 97 - 108 Aligned: 12 Modelled: 12 Confidence: 5.7% Identity: 50% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Families 57/38 glycoside transferase middle domain Family: AmyC C-terminal domain-like Phyre2 PDB 6gzf chain B Region: 140 - 198 Aligned: 51 Modelled: 59 Confidence: 5.6% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:glutathione s-transferase; PDBTitle: xi class gst from natrialba magadii Phyre2 PDB 3bsu chain F Region: 103 - 116 Aligned: 14 Modelled: 14 Confidence: 5.4% Identity: 21% PDB header:hydrolase/rna/dna Chain: F: PDB Molecule:ribonuclease h1; PDBTitle: hybrid-binding domain of human rnase h1 in complex with 12-2 mer rna/dna Phyre2 1 c3bgtD_ 2 c3bh2C_ 3 c4jmeA_ 4 d3c8wa1 5 c4zbtB_ 6 c5upbA_ 7 d3cmba1 8 c5jxpA_ 9 d1s1da_ 10 c2yueA_ 11 d1ttza_ 12 c3wolB_ 13 c5w6lA_ 14 c3jb9K_ 15 c2j58G_ 16 c5ijlA_ 17 c3fxtB_ 18 d2b5dx1 19 c6gzfB_ 20 c3bsuF_ 21