1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	T	D	V	R	V	R	R	A	I	T	A	M	A	G	G	H	A	V	V	L	T	G	D	P	N	G	D	G	Y	L	V	F	A	A	Q	A	A	T	P	R	L	V	A	F	A	V	R	H	T	S	G	Y	L	R	V	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	A	E	C	E	R	L	H	L	P	P	M	C	D	R	D	T	T	H	C	V	S	V	D	V	R	G	T	G	T	G	I	S	A	S	D	R	A	W	T	I	A	A	L	A	S	A	T	S	V	A	A	D	F	Q	R	P	G	H
Secondary structure
SS confidence
Disorder																																																	?		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	P	V	Q	A	Q	A	D	G	V	L	G	R	R	G	P	A	E	A	A	V	D	L	A	R	L	A	E	R	R	P	A	A	A	L	C	E	I	V	S	P	D	N	P	V	Q	M	A	H	H	A	E	S	V	E	F	A	V	E
Secondary structure
SS confidence
Disorder									?	?	?																																	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	G	L	A	M	V	S	I	G	E	L	V	A	Y	R	R	R	I	E	P	Q	V	V	R	F	T	A	A	T	L	P	T	W	A	G	A	S	R	V	I	G	F	R	D	V	Y	D	L	G	E	H	L	A	V	I	V	G	A	V	G
Secondary structure
SS confidence
Disorder																			?	?	?	?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	V	P	V	P	L	H	V	H	I	E	C	L	T	G	D	V	F	G	S	T	A	C	R	C	G	E	E	L	N	G	A	L	A	R	M	S	A	Q	G	S	G	V	V	L	Y	L	R	P	P	G	P	A	Q	A	C	G	L	F
Secondary structure
SS confidence
Disorder																																																						?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.
Sequence		A	R	G	D	A	A	T	D	V	M	P	E	T	V	T	W	I	L	R	D	L	G	V	Y	A	I	R	L	S	D	D	V	P	G	F	G	L	V	M	F	G	A	I	R	E	A	S	T	L	A	A	A	G
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?	?	?																																				?	?	?	?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 31%) Beta strand ( 27%)

Rank Aligned region

PDB 4i14 chain B Region: 3 - 344 Aligned: 313 Modelled: 321 Confidence: 100.0% Identity: 51% PDB header:hydrolase, lyase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribba; PDBTitle: crystal structure of mtb-riba2 (rv1415) Phyre2 PDB 6mnz chain B Region: 6 - 344 Aligned: 321 Modelled: 339 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: B: PDB Molecule:3,4-dihydroxy-2-butanone 4-phosphate synthase; PDBTitle: crystal structure of ribbx, a two domain 3,4-dihydroxy-2-butanone 4-2 phosphate synthase from a. baumannii. Phyre2 PDB 4ffj chain A Region: 7 - 201 Aligned: 191 Modelled: 195 Confidence: 100.0% Identity: 33% PDB header:lyase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribba; PDBTitle: the crystal structure of spdhbps from s.pneumoniae Phyre2 PDB 1k4i chain A Region: 7 - 202 Aligned: 196 Modelled: 196 Confidence: 100.0% Identity: 38% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB Phyre2 PDB 1g57 chain A Region: 1 - 199 Aligned: 195 Modelled: 199 Confidence: 100.0% Identity: 38% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB Phyre2 PDB 1snn chain A Region: 7 - 194 Aligned: 186 Modelled: 186 Confidence: 100.0% Identity: 30% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB Phyre2 PDB 1tks chain A Region: 3 - 197 Aligned: 192 Modelled: 194 Confidence: 100.0% Identity: 36% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB Phyre2 PDB 3mio chain A Region: 3 - 199 Aligned: 191 Modelled: 197 Confidence: 100.0% Identity: 56% PDB header:lyase Chain: A: PDB Molecule:3,4-dihydroxy-2-butanone 4-phosphate synthase; PDBTitle: crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase2 domain from mycobacterium tuberculosis at ph 6.00 Phyre2 PDB 4p6d chain A Region: 2 - 199 Aligned: 188 Modelled: 198 Confidence: 100.0% Identity: 38% PDB header:lyase Chain: A: PDB Molecule:3,4-dihydroxy-2-butanone 4-phosphate synthase; PDBTitle: structure of ribb complexed with po4 ion Phyre2 PDB 2bz1 chain A domain 1 Region: 200 - 344 Aligned: 145 Modelled: 144 Confidence: 100.0% Identity: 32% Fold: RibA-like Superfamily: RibA-like Family: RibA-like Phyre2 PDB 4rl4 chain B Region: 198 - 344 Aligned: 144 Modelled: 147 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:gtp cyclohydrolase-2; PDBTitle: crystal structure of gtp cyclohydrolase ii from helicobacter pylori2 26695 Phyre2 PDB 1y0n chain A Region: 3 - 34 Aligned: 32 Modelled: 32 Confidence: 82.4% Identity: 38% Fold: YehU-like Superfamily: YehU-like Family: YehU-like Phyre2 PDB 1lh0 chain A Region: 131 - 201 Aligned: 69 Modelled: 71 Confidence: 67.4% Identity: 12% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 5f56 chain A Region: 1 - 105 Aligned: 93 Modelled: 105 Confidence: 63.3% Identity: 19% PDB header:dna binding protein/dna Chain: A: PDB Molecule:single-stranded-dna-specific exonuclease; PDBTitle: structure of recj complexed with dna and ssb-ct Phyre2 PDB 1ko7 chain A domain 1 Region: 114 - 187 Aligned: 67 Modelled: 74 Confidence: 52.8% Identity: 13% Fold: MurF and HprK N-domain-like Superfamily: HprK N-terminal domain-like Family: HPr kinase/phoshatase HprK N-terminal domain Phyre2 PDB 4gij chain C Region: 129 - 187 Aligned: 53 Modelled: 59 Confidence: 49.0% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:pseudouridine-5'-phosphate glycosidase; PDBTitle: crystal structure of pseudouridine monophosphate glycosidase complexed2 with sulfate Phyre2 PDB 1js3 chain A Region: 139 - 186 Aligned: 47 Modelled: 48 Confidence: 43.6% Identity: 11% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: Pyridoxal-dependent decarboxylase Phyre2 PDB 1vkm chain A Region: 129 - 187 Aligned: 51 Modelled: 57 Confidence: 43.5% Identity: 18% Fold: Indigoidine synthase A-like Superfamily: Indigoidine synthase A-like Family: Indigoidine synthase A-like Phyre2 PDB 1oi2 chain A Region: 220 - 293 Aligned: 71 Modelled: 74 Confidence: 42.5% Identity: 11% Fold: DAK1/DegV-like Superfamily: DAK1/DegV-like Family: DAK1 Phyre2 PDB 6eei chain A Region: 139 - 186 Aligned: 47 Modelled: 48 Confidence: 38.1% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:tyrosine decarboxylase 1; PDBTitle: crystal structure of arabidopsis thaliana phenylacetaldehyde synthase2 in complex with l-phenylalanine Phyre2 1 c4i14B_ 2 c6mnzB_ 3 c4ffjA_ 4 d1k4ia_ 5 d1g57a_ 6 d1snna_ 7 d1tksa_ 8 c3mioA_ 9 c4p6dA_ 10 d2bz1a1 11 c4rl4B_ 12 d1y0na_ 13 d1lh0a_ 14 c5f56A_ 15 d1ko7a1 16 c4gijC_ 17 d1js3a_ 18 d1vkma_ 19 d1oi2a_ 20 c6eeiA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99