1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	Y	V	L	D	T	N	V	V	S	A	L	R	V	P	G	R	H	P	A	V	A	A	W	A	D	S	V	Q	V	A	E	Q	F	V	V	A	I	T	L	A	E	I	E	R	G	V	I	A	K	E	R	T	D	P	T	Q	S	E
Secondary structure
SS confidence
Disorder		?	?	?		?									?	?	?																																				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.
Sequence		H	L	R	R	W	F	D	D	K	V	L	R	I	F	V	F	A	R	R	G	T	N	L	I	M	Q	P	L	A	G	H	I	G	Y	S	L	Y	S	G	I	S	W	F
Secondary structure
SS confidence
Disorder																		?	?																							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 78%) Beta strand ( 4%)

Rank Aligned region

PDB 2h1c chain A domain 1 Region: 2 - 102 Aligned: 97 Modelled: 101 Confidence: 99.5% Identity: 27% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 6nkl chain A Region: 1 - 100 Aligned: 98 Modelled: 100 Confidence: 99.3% Identity: 14% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 3zvk chain C Region: 1 - 102 Aligned: 100 Modelled: 102 Confidence: 99.1% Identity: 14% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 3h87 chain B Region: 2 - 102 Aligned: 94 Modelled: 101 Confidence: 99.1% Identity: 12% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 3tnd chain C Region: 1 - 100 Aligned: 96 Modelled: 100 Confidence: 99.1% Identity: 15% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5sv2 chain A Region: 2 - 102 Aligned: 96 Modelled: 98 Confidence: 99.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 5l6m chain C Region: 2 - 97 Aligned: 91 Modelled: 96 Confidence: 98.9% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 1v96 chain A domain 1 Region: 2 - 102 Aligned: 92 Modelled: 101 Confidence: 98.8% Identity: 7% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4chg chain C Region: 2 - 93 Aligned: 88 Modelled: 92 Confidence: 98.8% Identity: 16% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 3dbo chain B Region: 3 - 102 Aligned: 85 Modelled: 100 Confidence: 98.7% Identity: 24% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 1y82 chain A domain 1 Region: 2 - 102 Aligned: 94 Modelled: 101 Confidence: 98.4% Identity: 5% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 6a7v chain G Region: 2 - 93 Aligned: 88 Modelled: 92 Confidence: 98.3% Identity: 15% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 4xgr chain G Region: 2 - 97 Aligned: 93 Modelled: 94 Confidence: 97.9% Identity: 11% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 2fe1 chain A domain 1 Region: 1 - 67 Aligned: 65 Modelled: 67 Confidence: 97.5% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2fe1 chain A Region: 1 - 67 Aligned: 65 Modelled: 67 Confidence: 97.5% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 5x3t chain D Region: 4 - 100 Aligned: 94 Modelled: 97 Confidence: 97.1% Identity: 14% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5wzf chain B Region: 2 - 58 Aligned: 56 Modelled: 57 Confidence: 95.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 2hww chain C Region: 3 - 68 Aligned: 57 Modelled: 66 Confidence: 93.8% Identity: 21% PDB header:rna binding protein Chain: C: PDB Molecule:telomerase-binding protein est1a; PDBTitle: structure of pin domain of human smg6 Phyre2 PDB 1v8p chain K Region: 1 - 97 Aligned: 88 Modelled: 97 Confidence: 88.1% Identity: 14% PDB header:structural genomics, unknown function Chain: K: PDB Molecule:hypothetical protein pae2754; PDBTitle: crystal structure of pae2754 from pyrobaculum aerophilum Phyre2 PDB 1v8p chain A Region: 1 - 97 Aligned: 88 Modelled: 88 Confidence: 88.0% Identity: 14% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 d2h1ca1 2 c6nklA_ 3 c3zvkC_ 4 c3h87B_ 5 c3tndC_ 6 c5sv2A_ 7 c5l6mC_ 8 d1v96a1 9 c4chgC_ 10 c3dboB_ 11 d1y82a1 12 c6a7vG_ 13 c4xgrG_ 14 d2fe1a1 15 c2fe1A_ 16 c5x3tD_ 17 c5wzfB_ 18 c2hwwC_ 19 c1v8pK_ 20 d1v8pa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47