1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	I	G	L	T	L	V	M	I	A	A	V	V	A	S	C	G	W	R	G	L	N	S	L	P	L	P	G	T	Q	G	N	G	P	G	S	F	A	V	Q	A	Q	L	P	D	V	N	N	I	Q	P	N	S	R	V	R	V	A	D
Secondary structure
SS confidence
Disorder		?	?	?																						?	?	?	?	?	?	?	?	?	?	?													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	T	V	G	H	V	T	K	I	E	R	Q	G	W	H	A	L	V	T	M	R	L	D	G	D	V	D	L	P	A	N	A	T	A	K	I	G	T	T	S	L	L	G	S	Y	H	I	E	L	A	P	P	K	G	E	A	R	Q	G	K
Secondary structure
SS confidence
Disorder													?												?														?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	D	G	S	L	I	A	L	S	H	G	S	A	Y	P	S	T	E	Q	T	L	A	A	L	S	L	V	L	N	G	G	G	L	G	Q	V	Q	D	I	T	E	A	L	S	T	A	F	A	G	R	E	H	D	L	R	G	L	I	G
Secondary structure
SS confidence
Disorder		?	?	?	?				?		?	?	?	?	?	?														?	?		?	?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	L	D	T	F	T	A	Y	L	N	N	Q	S	G	D	I	I	A	A	T	D	S	L	N	R	L	V	G	K	F	A	D	Q	Q	P	V	F	D	R	A	L	A	T	I	P	D	A	L	A	V	L	A	D	E	R	D	T	L	V	E
Secondary structure
SS confidence
Disorder												?	?	?																				?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	E	Q	L	S	K	F	S	A	L	T	V	D	S	V	N	K	T	T	A	N	L	V	T	E	L	R	Q	L	G	P	V	L	E	S	L	A	N	S	G	P	A	L	T	R	S	L	S	L	L	A	T	F	P	F	P	N	E	T
Secondary structure
SS confidence
Disorder																																								?	?	?																?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	Q	N	F	Q	R	G	E	Y	A	N	L	T	A	I	V	D	L	T	L	S	R	I	D	Q	G	L	L	T	G	T	R	W	E	C	H	L	T	Q	L	E	L	Q	W	G	R	T	I	G	Q	F	P	S	P	C	T	A	G	Y	R
Secondary structure
SS confidence
Disorder			?																					?	?	?					?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.
Sequence		G	T	P	G	N	P	L	T	I	A	Y	R	W	D	Q	G	P
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 48%) Beta strand ( 15%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 3 - 143 Aligned: 130 Modelled: 141 Confidence: 99.9% Identity: 25% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 35 - 133 Aligned: 97 Modelled: 99 Confidence: 99.9% Identity: 19% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain E Region: 34 - 187 Aligned: 139 Modelled: 122 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 34 - 187 Aligned: 139 Modelled: 122 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain D Region: 34 - 187 Aligned: 139 Modelled: 122 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 34 - 187 Aligned: 139 Modelled: 122 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 34 - 187 Aligned: 139 Modelled: 111 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 34 - 187 Aligned: 139 Modelled: 111 Confidence: 99.6% Identity: 14% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 1qu7 chain A Region: 137 - 291 Aligned: 151 Modelled: 155 Confidence: 94.0% Identity: 16% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 2wpq chain A Region: 175 - 274 Aligned: 99 Modelled: 100 Confidence: 91.3% Identity: 6% PDB header:membrane protein Chain: A: PDB Molecule:trimeric autotransporter adhesin fragment; PDBTitle: salmonella enterica sada 479-519 fused to gcn4 adaptors (sadak3, in-2 register fusion) Phyre2 PDB 2qf4 chain A Region: 39 - 127 Aligned: 84 Modelled: 89 Confidence: 89.8% Identity: 12% PDB header:structural protein Chain: A: PDB Molecule:cell shape determining protein mrec; PDBTitle: high resolution structure of the major periplasmic domain from the2 cell shape-determining filament mrec (orthorhombic form) Phyre2 PDB 3g67 chain A Region: 138 - 291 Aligned: 148 Modelled: 154 Confidence: 87.3% Identity: 11% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 1eq1 chain A Region: 175 - 283 Aligned: 109 Modelled: 109 Confidence: 85.7% Identity: 15% Fold: Apolipophorin-III Superfamily: Apolipophorin-III Family: Apolipophorin-III Phyre2 PDB 3zx6 chain A Region: 166 - 289 Aligned: 120 Modelled: 124 Confidence: 85.4% Identity: 16% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 3cwg chain A Region: 138 - 272 Aligned: 135 Modelled: 135 Confidence: 83.5% Identity: 12% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 3lnr chain A Region: 155 - 289 Aligned: 135 Modelled: 135 Confidence: 83.5% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 2ch7 chain A Region: 173 - 287 Aligned: 115 Modelled: 115 Confidence: 82.3% Identity: 6% PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima Phyre2 PDB 2j5u chain B Region: 41 - 101 Aligned: 55 Modelled: 61 Confidence: 78.2% Identity: 15% PDB header:cell shape regulation Chain: B: PDB Molecule:mrec protein; PDBTitle: mrec lysteria monocytogenes Phyre2 PDB 1deq chain F Region: 155 - 258 Aligned: 104 Modelled: 104 Confidence: 78.0% Identity: 8% PDB header:blood clotting Chain: F: PDB Molecule:fibrinogen (gamma chain); PDBTitle: the crystal structure of modified bovine fibrinogen (at ~42 angstrom resolution) Phyre2 PDB 4rh7 chain A Region: 152 - 305 Aligned: 154 Modelled: 154 Confidence: 74.9% Identity: 12% PDB header:motor protein Chain: A: PDB Molecule:green fluorescent protein/cytoplasmic dynein 2 heavy chain PDBTitle: crystal structure of human cytoplasmic dynein 2 motor domain in2 complex with adp.vi Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnE_ 4 c5uvnA_ 5 c5uvnD_ 6 c5uvnC_ 7 c5uvnB_ 8 c5uvnF_ 9 c1qu7A_ 10 c2wpqA_ 11 c2qf4A_ 12 c3g67A_ 13 d1eq1a_ 14 c3zx6A_ 15 c3cwgA_ 16 c3lnrA_ 17 c2ch7A_ 18 c2j5uB_ 19 c1deqF_ 20 c4rh7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99