1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	H	L	P	R	R	V	I	V	Q	L	A	V	F	T	V	I	A	V	G	V	L	A	I	T	F	L	H	F	V	R	L	P	A	M	L	F	G	V	G	R	Y	T	V	T	M	E	L	V	E	A	G	G	L	Y	R	T	G	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																											?	?	?	?	?	?	?													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	T	Y	R	G	F	E	V	G	R	V	A	A	V	R	L	T	D	T	G	V	Q	A	V	L	A	L	K	S	G	I	D	I	P	S	D	L	K	A	E	V	H	S	H	T	A	I	G	E	T	Y	V	E	L	L	P	R	N	A	A
Secondary structure
SS confidence
Disorder																		?																?											?	?	?	?	?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	P	P	L	K	N	G	D	V	I	A	L	A	D	T	S	V	P	P	D	I	N	D	L	L	S	A	A	N	T	A	L	E	A	I	P	H	E	N	L	Q	T	V	I	D	E	S	Y	T	A	V	A	G	L	G	L	E	L	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?		?				?	?	?	?	?	?	?	?	?	?																?																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	I	K	G	S	A	E	L	A	I	D	A	R	A	N	L	D	P	L	V	A	L	I	D	R	A	G	P	V	L	D	S	Q	T	H	T	S	D	A	I	A	A	W	A	A	Q	L	A	A	V	T	G	Q	L	Q	T	H	D	S	A
Secondary structure
SS confidence
Disorder																?																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	G	D	L	I	D	R	G	G	P	A	L	G	E	T	R	Q	L	L	E	R	L	Q	P	T	V	P	I	L	L	A	N	L	V	S	V	G	Q	V	A	L	T	Y	H	N	D	I	E	Q	L	L	V	V	F	P	M	A	I	A	A
Secondary structure
SS confidence
Disorder																																												?															?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	Q	A	G	I	L	A	N	L	N	T	K	Q	A	Y	R	G	Q	Y	L	S	F	N	L	N	L	N	L	P	P	P	C	T	T	G	F	L	P	A	Q	Q	R	R	I	P	T	F	E	D	Y	P	D	R	P	A	G	D	L	Y	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?																																?			?	?	?	?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	V	P	Q	D	S	P	F	N	V	R	G	A	R	N	I	P	C	E	T	V	P	G	K	R	A	P	T	V	K	L	C	E	S	D	A	P	Y	L	P	L	N	D	G	Y	N	W	K	G	D	P	N	A	T	V	P	G	L	G	S
Secondary structure
SS confidence
Disorder		?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.
Sequence		G	Q	D	I	P	Q	T	W	Q	T	M	L	L	P	P	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 42%) Beta strand ( 12%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 12 - 147 Aligned: 132 Modelled: 136 Confidence: 99.9% Identity: 27% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 40 - 136 Aligned: 97 Modelled: 97 Confidence: 99.9% Identity: 23% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain B Region: 39 - 190 Aligned: 139 Modelled: 119 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain D Region: 39 - 190 Aligned: 139 Modelled: 119 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 39 - 190 Aligned: 139 Modelled: 119 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 39 - 190 Aligned: 139 Modelled: 120 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain E Region: 39 - 190 Aligned: 139 Modelled: 119 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 39 - 190 Aligned: 139 Modelled: 119 Confidence: 99.5% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 1qu7 chain A Region: 141 - 290 Aligned: 150 Modelled: 150 Confidence: 94.7% Identity: 17% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 3g67 chain A Region: 141 - 304 Aligned: 162 Modelled: 164 Confidence: 84.3% Identity: 6% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 3cwg chain A Region: 141 - 275 Aligned: 135 Modelled: 135 Confidence: 83.6% Identity: 12% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 1eq1 chain A Region: 141 - 287 Aligned: 124 Modelled: 130 Confidence: 81.5% Identity: 10% Fold: Apolipophorin-III Superfamily: Apolipophorin-III Family: Apolipophorin-III Phyre2 PDB 2j5u chain B Region: 46 - 106 Aligned: 55 Modelled: 61 Confidence: 80.9% Identity: 20% PDB header:cell shape regulation Chain: B: PDB Molecule:mrec protein; PDBTitle: mrec lysteria monocytogenes Phyre2 PDB 3zx6 chain A Region: 169 - 290 Aligned: 122 Modelled: 122 Confidence: 79.1% Identity: 16% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 2ch7 chain A Region: 158 - 290 Aligned: 133 Modelled: 133 Confidence: 78.6% Identity: 11% PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima Phyre2 PDB 2qf4 chain A Region: 44 - 130 Aligned: 84 Modelled: 87 Confidence: 78.5% Identity: 19% PDB header:structural protein Chain: A: PDB Molecule:cell shape determining protein mrec; PDBTitle: high resolution structure of the major periplasmic domain from the2 cell shape-determining filament mrec (orthorhombic form) Phyre2 PDB 1st6 chain A domain 4 Region: 199 - 276 Aligned: 78 Modelled: 78 Confidence: 78.4% Identity: 17% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 5xbj chain A Region: 142 - 260 Aligned: 116 Modelled: 119 Confidence: 75.0% Identity: 14% PDB header:biosynthetic protein Chain: A: PDB Molecule:flagellar hook-associated protein flgk; PDBTitle: the structure of the flagellar hook junction protein hap1 (flgk) from2 campylobacter jejuni Phyre2 PDB 2yfa chain A Region: 141 - 294 Aligned: 154 Modelled: 154 Confidence: 73.1% Identity: 13% PDB header:receptor Chain: A: PDB Molecule:methyl-accepting chemotaxis transducer; PDBTitle: x-ray structure of mcps ligand binding domain in complex with malate Phyre2 PDB 2ieq chain C Region: 176 - 265 Aligned: 85 Modelled: 90 Confidence: 72.2% Identity: 7% PDB header:viral protein Chain: C: PDB Molecule:spike glycoprotein; PDBTitle: core structure of s2 from the human coronavirus nl63 spike2 glycoprotein Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnB_ 4 c5uvnD_ 5 c5uvnF_ 6 c5uvnC_ 7 c5uvnE_ 8 c5uvnA_ 9 c1qu7A_ 10 c3g67A_ 11 c3cwgA_ 12 d1eq1a_ 13 c2j5uB_ 14 c3zx6A_ 15 c2ch7A_ 16 c2qf4A_ 17 d1st6a4 18 c5xbjA_ 19 c2yfaA_ 20 c2ieqC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99