1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	W	I	V	D	G	M	N	V	I	G	S	R	P	D	G	W	W	R	D	R	H	R	A	M	V	M	L	V	E	R	L	E	G	W	A	I	T	K	A	R	G	D	D	V	T	V	V	F	E	R	P	P	S	T	A	I	P	S
Secondary structure
SS confidence
Disorder		?																				?	?													?	?		?	?	?	?															?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	V	V	E	V	A	H	A	P	K	A	A	A	N	S	A	D	D	E	I	V	R	L	V	R	S	G	A	Q	P	Q	E	I	R	V	V	T	S	D	K	A	L	T	D	R	V	R	D	L	G	A	A	V	Y	P	A	E	R	F	R
Secondary structure
SS confidence
Disorder		?	?			?					?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.
Sequence		D	L	I	D	P	R	G	S	N	A	A	R	R	T	Q
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 44%) Beta strand ( 19%)

Rank Aligned region

PDB 5mq9 chain A Region: 3 - 135 Aligned: 124 Modelled: 133 Confidence: 100.0% Identity: 24% PDB header:translation Chain: A: PDB Molecule:uncharacterized protein yacp; PDBTitle: crystal structure of rae1 (yacp) from bacillus subtilis (w164l mutant) Phyre2 PDB 1cmw chain A domain 2 Region: 3 - 100 Aligned: 96 Modelled: 98 Confidence: 97.6% Identity: 25% Fold: PIN domain-like Superfamily: PIN domain-like Family: 5' to 3' exonuclease catalytic domain Phyre2 PDB 1cmw chain A Region: 3 - 100 Aligned: 96 Modelled: 98 Confidence: 97.4% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:protein (dna polymerase i); PDBTitle: crystal structure of taq dna-polymerase shows a new orientation for2 the structure-specific nuclease domain Phyre2 PDB 3zdd chain A Region: 3 - 100 Aligned: 93 Modelled: 98 Confidence: 97.4% Identity: 23% PDB header:hydrolase/dna Chain: A: PDB Molecule:protein xni; PDBTitle: structure of e. coli exoix in complex with the palindromic 5ov62 oligonucleotide and potassium Phyre2 PDB 6c34 chain A Region: 3 - 100 Aligned: 96 Modelled: 98 Confidence: 97.3% Identity: 18% PDB header:dna binding protein Chain: A: PDB Molecule:5'-3' exonuclease; PDBTitle: mycobacterium smegmatis dna flap endonuclease mutant d125n Phyre2 PDB 1ut8 chain B Region: 3 - 100 Aligned: 91 Modelled: 98 Confidence: 97.2% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:exodeoxyribonuclease; PDBTitle: divalent metal ions (zinc) bound to t5 5'-exonuclease Phyre2 PDB 1tfr chain A domain 2 Region: 3 - 116 Aligned: 112 Modelled: 114 Confidence: 97.0% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: 5' to 3' exonuclease catalytic domain Phyre2 PDB 1xo1 chain A domain 2 Region: 3 - 100 Aligned: 87 Modelled: 98 Confidence: 96.9% Identity: 21% Fold: PIN domain-like Superfamily: PIN domain-like Family: 5' to 3' exonuclease catalytic domain Phyre2 PDB 3v32 chain B Region: 2 - 100 Aligned: 88 Modelled: 95 Confidence: 95.9% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:ribonuclease zc3h12a; PDBTitle: crystal structure of mcpip1 n-terminal conserved domain Phyre2 PDB 3v33 chain A Region: 2 - 100 Aligned: 88 Modelled: 93 Confidence: 95.6% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease zc3h12a; PDBTitle: crystal structure of mcpip1 conserved domain with zinc-finger motif Phyre2 PDB 3ix7 chain A Region: 71 - 125 Aligned: 51 Modelled: 55 Confidence: 94.6% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 2izo chain A Region: 2 - 102 Aligned: 95 Modelled: 98 Confidence: 94.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:flap structure-specific endonuclease; PDBTitle: structure of an archaeal pcna1-pcna2-fen1 complex Phyre2 PDB 1ul1 chain X domain 2 Region: 2 - 99 Aligned: 89 Modelled: 98 Confidence: 93.7% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: 5' to 3' exonuclease catalytic domain Phyre2 PDB 2hww chain C Region: 72 - 122 Aligned: 51 Modelled: 50 Confidence: 93.1% Identity: 20% PDB header:rna binding protein Chain: C: PDB Molecule:telomerase-binding protein est1a; PDBTitle: structure of pin domain of human smg6 Phyre2 PDB 1b43 chain A Region: 2 - 99 Aligned: 89 Modelled: 94 Confidence: 92.2% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:protein (fen-1); PDBTitle: fen-1 from p. furiosus Phyre2 PDB 1o4w chain A Region: 70 - 115 Aligned: 42 Modelled: 46 Confidence: 91.9% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 5jpq chain D Region: 72 - 114 Aligned: 40 Modelled: 43 Confidence: 91.7% Identity: 33% PDB header:ribosome Chain: D: PDB Molecule:wd40 domain proteins; PDBTitle: cryo-em structure of the 90s pre-ribosome Phyre2 PDB 1a77 chain A Region: 2 - 99 Aligned: 92 Modelled: 95 Confidence: 90.5% Identity: 25% PDB header:5'-3' exo/endo nuclease Chain: A: PDB Molecule:flap endonuclease-1 protein; PDBTitle: flap endonuclease-1 from methanococcus jannaschii Phyre2 PDB 2ihn chain A Region: 68 - 116 Aligned: 49 Modelled: 49 Confidence: 90.3% Identity: 18% PDB header:hydrolase/dna Chain: A: PDB Molecule:ribonuclease h; PDBTitle: co-crystal of bacteriophage t4 rnase h with a fork dna2 substrate Phyre2 PDB 4wa8 chain A Region: 2 - 99 Aligned: 89 Modelled: 95 Confidence: 89.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:flap endonuclease 1; PDBTitle: methanopyrus kandleri fen-1 nuclease Phyre2 1 c5mq9A_ 2 d1cmwa2 3 c1cmwA_ 4 c3zddA_ 5 c6c34A_ 6 c1ut8B_ 7 d1tfra2 8 d1xo1a2 9 c3v32B_ 10 c3v33A_ 11 c3ix7A_ 12 c2izoA_ 13 d1ul1x2 14 c2hwwC_ 15 c1b43A_ 16 d1o4wa_ 17 c5jpqd_ 18 c1a77A_ 19 c2ihnA_ 20 c4wa8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99