1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	T	P	A	T	T	R	K	T	F	P	E	I	S	S	R	A	W	E	H	P	A	D	R	T	A	L	S	A	L	R	R	L	K	G	F	D	Q	I	L	K	L	M	S	G	M	L	R	E	R	Q	H	R	L	L	Y	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?		?	?	?	?																				?																							?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	A	A	R	V	G	P	R	Q	F	A	D	L	D	A	L	L	D	E	C	V	D	V	L	D	A	S	A	K	P	E	L	Y	V	M	Q	S	P	I	A	D	A	F	T	I	G	M	G	K	P	F	T	V	I	T	S	G	L	Y	D
Secondary structure
SS confidence
Disorder		?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	V	T	H	D	E	M	R	F	V	M	G	H	E	L	G	H	A	L	S	G	H	A	V	Y	R	T	M	M	M	H	L	L	R	L	A	R	S	F	G	V	L	P	V	G	G	W	A	L	R	A	I	V	A	A	L	L	E	W	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	K	S	E	L	S	G	D	R	A	G	L	L	C	A	Q	D	L	D	T	A	L	R	V	E	M	K	L	A	G	G	C	R	L	D	K	L	D	S	E	A	F	L	A	Q	A	R	E	Y	E	T	S	G	D	M	R	D	G	V	L
Secondary structure
SS confidence
Disorder																														?			?	?	?	?	?	?		?									?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	L	L	N	L	E	L	Q	T	H	P	F	S	V	L	R	A	A	A	L	T	H	W	V	D	T	G	G	Y	A	K	V	I	A	G	E	Y	P	R	R	A	D	D	G	N	A	K	F	A	D	D	L	G	A	A	A	R	Y	Y	R
Secondary structure
SS confidence
Disorder																									?	?								?	?		?	?	?	?	?	?		?	?	?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.
Sequence		D	G	F	D	Q	S	N	D	P	L	I	K	G	I	R	D	G	F	G	G	I	V	E	G	V	G	R	A	A	S	N	A	A	D	S	L	G	R	K	I	T	E	W	R	Q	P	S	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																																		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 67%) Beta strand ( 4%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3c37 chain B Region: 36 - 278 Aligned: 203 Modelled: 205 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 4il3 chain B Region: 64 - 261 Aligned: 175 Modelled: 177 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:ste24p; PDBTitle: crystal structure of s. mikatae ste24p Phyre2 PDB 4aw6 chain B Region: 64 - 262 Aligned: 176 Modelled: 178 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:caax prenyl protease 1 homolog; PDBTitle: crystal structure of the human nuclear membrane zinc metalloprotease2 zmpste24 (face1) Phyre2 PDB 6ait chain D Region: 49 - 266 Aligned: 184 Modelled: 193 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:beta-barrel assembly-enhancing protease; PDBTitle: crystal structure of e. coli bepa Phyre2 PDB 3cqb chain B Region: 68 - 142 Aligned: 74 Modelled: 75 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 4jix chain B Region: 72 - 142 Aligned: 70 Modelled: 71 Confidence: 98.7% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:projannalysin; PDBTitle: crystal structure of the metallopeptidase zymogen of2 methanocaldococcus jannaschii jannalysin Phyre2 PDB 4jiu chain A Region: 73 - 142 Aligned: 67 Modelled: 70 Confidence: 97.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:proabylysin; PDBTitle: crystal structure of the metallopeptidase zymogen of pyrococcus abyssi2 abylysin Phyre2 PDB 3dtk chain A Region: 77 - 230 Aligned: 119 Modelled: 134 Confidence: 96.7% Identity: 17% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 6mdx chain A Region: 70 - 138 Aligned: 69 Modelled: 67 Confidence: 96.5% Identity: 19% PDB header:dna binding protein/dna Chain: A: PDB Molecule:sprt-like domain-containing protein spartan; PDBTitle: mechanism of protease dependent dpc repair Phyre2 PDB 6cz6 chain D Region: 70 - 144 Aligned: 71 Modelled: 75 Confidence: 94.8% Identity: 8% PDB header:transcription Chain: D: PDB Molecule:hth-type transcriptional regulator prpr; PDBTitle: mycobacterium tuberculosis transcriptional regulator Phyre2 PDB 3sks chain A Region: 68 - 141 Aligned: 69 Modelled: 74 Confidence: 94.2% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames Phyre2 PDB 2h1j chain A Region: 68 - 141 Aligned: 68 Modelled: 72 Confidence: 93.2% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding Phyre2 PDB 3ce2 chain A Region: 91 - 141 Aligned: 46 Modelled: 51 Confidence: 91.0% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus Phyre2 PDB 2ajf chain A domain 1 Region: 70 - 145 Aligned: 70 Modelled: 76 Confidence: 82.9% Identity: 17% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neurolysin-like Phyre2 PDB 4fgm chain A Region: 67 - 137 Aligned: 71 Modelled: 71 Confidence: 82.0% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n family protein; PDBTitle: crystal structure of the aminopeptidase n family protein q5qty1 from2 idiomarina loihiensis. northeast structural genomics consortium3 target ilr60. Phyre2 PDB 2xs4 chain A Region: 127 - 140 Aligned: 14 Modelled: 14 Confidence: 80.7% Identity: 43% PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with magnesium Phyre2 PDB 5xbv chain A Region: 122 - 142 Aligned: 21 Modelled: 21 Confidence: 78.7% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:wss1p; PDBTitle: crystal structure of wss1 mutant from saccharomyces cerevisiae Phyre2 PDB 1wgz chain C Region: 36 - 139 Aligned: 100 Modelled: 104 Confidence: 78.2% Identity: 19% PDB header:hydrolase Chain: C: PDB Molecule:carboxypeptidase 1; PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus Phyre2 PDB 1c7k chain A Region: 92 - 140 Aligned: 46 Modelled: 49 Confidence: 78.0% Identity: 24% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Zinc protease Phyre2 PDB 1k9x chain A Region: 72 - 139 Aligned: 65 Modelled: 68 Confidence: 77.6% Identity: 20% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neurolysin-like Phyre2 1 c3c37B_ 2 c4il3B_ 3 c4aw6B_ 4 c6aitD_ 5 c3cqbB_ 6 c4jixB_ 7 c4jiuA_ 8 c3dtkA_ 9 c6mdxA_ 10 c6cz6D_ 11 c3sksA_ 12 c2h1jA_ 13 c3ce2A_ 14 d2ajfa1 15 c4fgmA_ 16 c2xs4A_ 17 c5xbvA_ 18 c1wgzC_ 19 d1c7ka_ 20 d1k9xa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142