1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	G	P	R	T	R	G	Y	A	I	H	K	L	G	F	C	S	V	V	M	L	G	I	N	S	I	I	G	A	G	I	F	L	T	P	G	E	V	I	G	L	A	G	P	F	A	P	M	A	Y	V	L	A	G	I	F	A	G	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	I	V	F	A	T	A	A	R	Y	V	R	T	N	G	A	S	Y	A	Y	T	T	A	A	F	G	R	R	I	G	I	Y	V	G	V	T	H	A	I	T	A	S	I	A	W	G	V	L	A	S	F	F	V	S	T	L	L	R	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	F	P	D	K	A	W	A	D	A	E	Q	L	F	S	V	K	T	L	T	F	L	G	F	I	G	V	L	L	A	I	N	L	F	G	N	R	A	I	K	W	A	N	G	T	S	T	V	G	K	A	F	A	L	S	A	F	I	V	G
Secondary structure
SS confidence
Disorder						?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	L	W	I	I	T	T	Q	H	V	N	N	Y	A	T	A	W	S	A	Y	S	A	T	P	Y	S	L	L	G	V	A	E	I	G	K	G	T	F	S	S	M	A	L	A	T	I	V	A	L	Y	A	F	T	G	F	E	S	I	A	N
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	E	E	M	D	A	P	D	R	N	L	P	R	A	I	P	I	A	I	F	S	V	G	A	I	Y	L	L	T	L	T	V	A	M	L	L	G	S	N	K	I	A	A	S	D	D	T	V	K	L	A	A	A	I	G	N	A	T	F
Secondary structure
SS confidence
Disorder																																						?				?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	T	I	I	V	V	G	A	L	I	S	M	F	G	I	N	V	A	A	S	F	G	A	P	R	L	W	T	A	L	A	D	S	G	V	L	P	T	R	L	S	R	K	N	Q	Y	D	V	P	M	V	S	F	A	I	T	A	S	L	A
Secondary structure
SS confidence
Disorder																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	A	F	P	L	A	L	R	F	D	N	L	H	L	T	G	L	A	V	I	A	R	F	V	Q	F	I	I	V	P	I	A	L	I	A	L	A	R	S	Q	A	V	E	H	A	A	V	R	R	N	A	F	T	D	K	V	L	P	L	V
Secondary structure
SS confidence
Disorder																																										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	I	V	V	S	V	G	L	A	V	S	Y	D	Y	R	C	I	F	L	V	R	G	G	P	N	Y	F	S	I	A	L	I	V	I	T	F	I	V	V	P	A	M	A	Y	L	H	Y	Y	R	I	I	R	R	V	G	D	R	P	S	T
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		R
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 75%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 4dji chain A Region: 12 - 480 Aligned: 447 Modelled: 455 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 6f2w chain A Region: 11 - 476 Aligned: 426 Modelled: 426 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:putative amino acid/polyamine transport protein; PDBTitle: bacterial asc transporter crystal structure in open to in conformation Phyre2 PDB 6irt chain B Region: 15 - 473 Aligned: 429 Modelled: 429 Confidence: 100.0% Identity: 21% PDB header:membrane protein Chain: B: PDB Molecule:large neutral amino acids transporter small subunit 1; PDBTitle: human lat1-4f2hc complex bound with bch Phyre2 PDB 5oqt chain A Region: 7 - 473 Aligned: 434 Modelled: 434 Confidence: 100.0% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:amino acid transporter; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue Phyre2 PDB 6npl chain A Region: 13 - 481 Aligned: 440 Modelled: 451 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:solute carrier family 12 (sodium/potassium/chloride PDBTitle: cryo-em structure of nkcc1 Phyre2 PDB 3gia chain A Region: 9 - 481 Aligned: 429 Modelled: 429 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 6jmq chain A Region: 14 - 469 Aligned: 399 Modelled: 399 Confidence: 100.0% Identity: 21% PDB header:membrane protein/immune system Chain: A: PDB Molecule:large neutral amino acids transporter small subunit 1; PDBTitle: lat1-cd98hc complex bound to mem-108 fab Phyre2 PDB 3lrc chain C Region: 10 - 478 Aligned: 405 Modelled: 405 Confidence: 100.0% Identity: 25% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 6csf chain C Region: 5 - 412 Aligned: 380 Modelled: 380 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: C: PDB Molecule:sodium/alanine symporter agcs; PDBTitle: crystal structure of sodium/alanine symporter agcs with d-alanine2 bound Phyre2 PDB 2jln chain A Region: 5 - 480 Aligned: 439 Modelled: 476 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 6c08 chain F Region: 18 - 434 Aligned: 383 Modelled: 383 Confidence: 99.9% Identity: 11% PDB header:membrane protein Chain: F: PDB Molecule:sodium-coupled neutral amino acid transporter 9; PDBTitle: zebrafish slc38a9 with arginine bound in the cytosol open state Phyre2 PDB 5nva chain A Region: 12 - 461 Aligned: 413 Modelled: 426 Confidence: 99.7% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:putative sodium:solute symporter; PDBTitle: substrate-bound outward-open state of a na+-coupled sialic acid2 symporter reveals a novel na+-site Phyre2 PDB 6c08 chain C Region: 18 - 434 Aligned: 360 Modelled: 360 Confidence: 99.6% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:sodium-coupled neutral amino acid transporter 9; PDBTitle: zebrafish slc38a9 with arginine bound in the cytosol open state Phyre2 PDB 3dh4 chain A Region: 12 - 481 Aligned: 442 Modelled: 442 Confidence: 99.6% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2xq2 chain A Region: 12 - 481 Aligned: 442 Modelled: 442 Confidence: 99.6% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 5m87 chain A Region: 3 - 474 Aligned: 457 Modelled: 472 Confidence: 99.3% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of eremococcus coleocola manganese transporter Phyre2 PDB 4wgw chain A Region: 28 - 427 Aligned: 377 Modelled: 377 Confidence: 99.2% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: staphylococcus capitis divalent metal ion transporter (dmt) in complex2 with manganese Phyre2 PDB 4wgv chain C Region: 28 - 427 Aligned: 377 Modelled: 377 Confidence: 99.2% Identity: 8% PDB header:transport protein Chain: C: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of staphylococcus capitis divalent metal ion2 transporter (dmt) in complex with nanobody Phyre2 PDB 5i6x chain A Region: 6 - 475 Aligned: 449 Modelled: 457 Confidence: 98.8% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:sodium-dependent serotonin transporter; PDBTitle: x-ray structure of the ts3 human serotonin transporter complexed with2 paroxetine at the central site Phyre2 PDB 4m48 chain A Region: 15 - 476 Aligned: 441 Modelled: 441 Confidence: 98.8% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:transporter; PDBTitle: x-ray structure of dopamine transporter elucidates antidepressant2 mechanism Phyre2 1 c4djiA_ 2 c6f2wA_ 3 c6irtB_ 4 c5oqtA_ 5 c6nplA_ 6 c3giaA_ 7 c6jmqA_ 8 c3lrcC_ 9 c6csfC_ 10 c2jlnA_ 11 c6c08F_ 12 c5nvaA_ 13 c6c08C_ 14 c3dh4A_ 15 c2xq2A_ 16 c5m87A_ 17 c4wgwA_ 18 c4wgvC_ 19 c5i6xA_ 20 c4m48A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34