1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	G	K	L	V	E	R	V	H	A	I	N	W	N	R	L	L	D	A	K	D	L	Q	V	W	E	R	L	T	G	N	F	W	L	P	E	K	I	P	L	S	N	D	L	A	S	W	Q	T	L	S	S	T	E	Q	Q	T	T	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	V	F	T	G	L	T	L	L	D	T	A	Q	A	T	V	G	A	V	A	M	I	D	D	A	V	T	P	H	E	E	A	V	L	T	N	M	A	F	M	E	S	V	H	A	K	S	Y	S	S	I	F	S	T	L	C	S	T	K	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	D	D	A	F	D	W	S	E	Q	N	P	Y	L	Q	R	K	A	Q	I	I	V	D	Y	Y	R	G	D	D	A	L	K	R	K	A	S	S	V	M	L	E	S	F	L	F	Y	S	G	F	Y	L	P	M	Y	W	S	S	R	G	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	T	N	T	A	D	L	I	R	L	I	I	R	D	E	A	V	H	G	Y	Y	I	G	Y	K	C	Q	R	G	L	A	D	L	T	D	A	E	R	A	D	H	R	E	Y	T	C	E	L	L	H	T	L	Y	A	N	E	I	D	Y	A
Secondary structure
SS confidence
Disorder																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	D	L	Y	D	E	L	G	W	T	D	D	V	L	P	Y	M	R	Y	N	A	N	K	A	L	A	N	L	G	Y	Q	P	A	F	D	R	D	T	C	Q	V	N	P	A	V	R	A	A	L	D	P	G	A	G	E	N	H	D	F	F
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Sequence		S	G	S	G	S	S	Y	V	M	G	T	H	Q	P	T	T	D	T	D	W	D	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 72%) Beta strand ( 0%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 1oqu chain C Region: 3 - 299 Aligned: 294 Modelled: 294 Confidence: 100.0% Identity: 63% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 6gp2 chain A Region: 4 - 300 Aligned: 294 Modelled: 297 Confidence: 100.0% Identity: 45% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase beta chain; PDBTitle: ribonucleotide reductase class ie r2 from mesoplasma florum, dopa-2 active form Phyre2 PDB 4n83 chain F Region: 7 - 290 Aligned: 284 Modelled: 284 Confidence: 100.0% Identity: 52% PDB header:oxidoreductase Chain: F: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: x-ray crystal structure of streptococcus sanguinis dimanganese(ii)-2 nrdf Phyre2 PDB 1r2f chain A Region: 9 - 291 Aligned: 283 Modelled: 283 Confidence: 100.0% Identity: 65% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1r2f chain B Region: 9 - 289 Aligned: 281 Modelled: 281 Confidence: 100.0% Identity: 65% PDB header:oxidoreductase Chain: B: PDB Molecule:protein (ribonucleotide reductase r2); PDBTitle: ribonucleotide reductase r2f protein from salmonella2 typhimurium Phyre2 PDB 3dhz chain A domain 1 Region: 7 - 290 Aligned: 284 Modelled: 284 Confidence: 100.0% Identity: 65% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1uzr chain A Region: 8 - 289 Aligned: 282 Modelled: 282 Confidence: 100.0% Identity: 71% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4bmt chain B Region: 10 - 289 Aligned: 278 Modelled: 280 Confidence: 100.0% Identity: 43% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of ribonucleotide reductase di-iron nrdf2 from bacillus cereus Phyre2 PDB 4dr0 chain A Region: 5 - 289 Aligned: 283 Modelled: 285 Confidence: 100.0% Identity: 45% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of bacillus subtilis dimanganese(ii) nrdf Phyre2 PDB 1yfd chain A Region: 7 - 289 Aligned: 278 Modelled: 283 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase 1 beta chain; PDBTitle: crystal structure of the y122h mutant of ribonucleotide reductase r22 protein from e. coli Phyre2 PDB 6cwq chain A Region: 11 - 302 Aligned: 287 Modelled: 292 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase; PDBTitle: x-ray crystal structure of flavobacterium johnsoniae dimanganese(ii)2 ribonucleotide reductase beta subunit (as-isolated) Phyre2 PDB 2rcc chain C Region: 7 - 285 Aligned: 278 Modelled: 279 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: C: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of putative class i ribonucleotide reductase2 (np_241368.1) from bacillus halodurans at 1.90 a resolution Phyre2 PDB 1mxr chain A Region: 7 - 289 Aligned: 278 Modelled: 283 Confidence: 100.0% Identity: 24% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1sms chain A Region: 5 - 309 Aligned: 284 Modelled: 301 Confidence: 100.0% Identity: 15% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1syy chain A Region: 7 - 287 Aligned: 275 Modelled: 281 Confidence: 100.0% Identity: 20% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1syy chain A Region: 7 - 287 Aligned: 275 Modelled: 281 Confidence: 100.0% Identity: 20% PDB header:replication,oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase beta chain; PDBTitle: crystal structure of the r2 subunit of ribonucleotide reductase from2 chlamydia trachomatis Phyre2 PDB 5olk chain D Region: 10 - 291 Aligned: 277 Modelled: 282 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase, beta subunit 1; PDBTitle: crystal structure of the atp-cone-containing nrdb from2 leeuwenhoekiella blandensis Phyre2 PDB 1jk0 chain A Region: 16 - 288 Aligned: 262 Modelled: 269 Confidence: 100.0% Identity: 20% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1h0o chain A Region: 10 - 288 Aligned: 268 Modelled: 279 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: cobalt substitution of mouse r2 ribonucleotide reductase to2 model the reactive diferrous state Phyre2 PDB 1w68 chain A Region: 10 - 284 Aligned: 264 Modelled: 271 Confidence: 100.0% Identity: 18% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 1 d1oquc_ 2 c6gp2A_ 3 c4n83F_ 4 d1r2fa_ 5 c1r2fB_ 6 d3dhza1 7 d1uzra_ 8 c4bmtB_ 9 c4dr0A_ 10 c1yfdA_ 11 c6cwqA_ 12 c2rccC_ 13 d1mxra_ 14 d1smsa_ 15 d1syya_ 16 c1syyA_ 17 c5olkD_ 18 d1jk0a_ 19 c1h0oA_ 20 d1w68a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122