1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	I	S	R	A	E	I	Y	W	A	D	L	G	P	P	S	G	S	Q	P	A	K	R	R	P	V	L	V	I	Q	S	D	P	Y	N	A	S	R	L	A	T	V	I	A	A	V	I	T	S	N	T	A	L	A	A	M	P	G	N
Secondary structure
SS confidence
Disorder		?	?																?	?																?	?	?														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.
Sequence		V	F	L	P	A	T	T	T	R	L	P	R	D	S	V	V	N	V	T	A	I	V	T	L	N	K	T	D	L	T	D	R	V	G	E	V	P	A	S	L	M	H	E	V	D	R	G	L	R	R	V	L	D	L
Secondary structure
SS confidence
Disorder								?	?																																												?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 19%) Beta strand ( 35%)

Rank Aligned region

PDB 1ne8 chain A Region: 1 - 114 Aligned: 113 Modelled: 114 Confidence: 99.9% Identity: 37% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 4mzp chain C Region: 3 - 114 Aligned: 111 Modelled: 112 Confidence: 99.9% Identity: 37% PDB header:hydrolase Chain: C: PDB Molecule:mazf mrna interferase; PDBTitle: mazf from s. aureus crystal form iii, c2221, 2.7 a Phyre2 PDB 5hjz chain A Region: 3 - 114 Aligned: 110 Modelled: 112 Confidence: 99.9% Identity: 30% PDB header:hydrolase/rna Chain: A: PDB Molecule:endoribonuclease mazf9; PDBTitle: structure of m. tuberculosis mazf-mt1 (rv2801c) in complex with rna Phyre2 PDB 5hk3 chain B Region: 2 - 114 Aligned: 103 Modelled: 113 Confidence: 99.9% Identity: 98% PDB header:hydrolase/dna Chain: B: PDB Molecule:endoribonuclease mazf6; PDBTitle: crystal structure of m. tuberculosis mazf-mt3 t52d-f62d mutant in2 complex with dna Phyre2 PDB 1m1f chain A Region: 3 - 113 Aligned: 106 Modelled: 111 Confidence: 99.9% Identity: 26% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5wyg chain C Region: 1 - 114 Aligned: 103 Modelled: 114 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:probable endoribonuclease mazf7; PDBTitle: the crystal structure of the apo form of mtb mazf Phyre2 PDB 1ub4 chain A Region: 4 - 113 Aligned: 96 Modelled: 110 Confidence: 99.9% Identity: 20% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5xe3 chain B Region: 4 - 114 Aligned: 93 Modelled: 93 Confidence: 99.9% Identity: 29% PDB header:hydrolase/antitoxin Chain: B: PDB Molecule:endoribonuclease mazf4; PDBTitle: endoribonuclease in complex with its cognate antitoxin from2 mycobacterial species Phyre2 PDB 5cca chain A Region: 23 - 114 Aligned: 88 Modelled: 92 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:endoribonuclease mazf3; PDBTitle: crystal structure of mtb toxin Phyre2 PDB 3jrz chain A Region: 5 - 112 Aligned: 95 Modelled: 108 Confidence: 95.0% Identity: 12% PDB header:toxin Chain: A: PDB Molecule:ccdb; PDBTitle: ccdbvfi-formii-ph5.6 Phyre2 PDB 3vub chain A Region: 5 - 112 Aligned: 96 Modelled: 108 Confidence: 92.9% Identity: 9% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: CcdB Phyre2 PDB 1h3z chain A Region: 1 - 113 Aligned: 94 Modelled: 113 Confidence: 62.3% Identity: 7% Fold: SH3-like barrel Superfamily: Tudor/PWWP/MBT Family: PWWP domain Phyre2 PDB 5ikj chain A Region: 3 - 36 Aligned: 27 Modelled: 34 Confidence: 60.4% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:cryptic loci regulator 2; PDBTitle: structure of clr2 bound to the clr1 c-terminus Phyre2 PDB 5vc8 chain B Region: 1 - 111 Aligned: 94 Modelled: 111 Confidence: 54.4% Identity: 10% PDB header:dna binding protein Chain: B: PDB Molecule:histone-lysine n-methyltransferase nsd2; PDBTitle: crystal structure of the whsc1 pwwp1 domain Phyre2 PDB 3mxu chain A Region: 6 - 34 Aligned: 28 Modelled: 29 Confidence: 42.5% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from bartonella2 henselae Phyre2 PDB 1ex0 chain A domain 1 Region: 2 - 67 Aligned: 66 Modelled: 66 Confidence: 39.9% Identity: 11% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Transglutaminase N-terminal domain Phyre2 PDB 2edg chain A Region: 6 - 30 Aligned: 24 Modelled: 25 Confidence: 37.0% Identity: 17% PDB header:biosynthetic protein Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: solution structure of the gcv_h domain from mouse glycine Phyre2 PDB 2l89 chain A Region: 3 - 113 Aligned: 90 Modelled: 111 Confidence: 36.3% Identity: 10% PDB header:protein binding Chain: A: PDB Molecule:pwwp domain-containing protein 1; PDBTitle: solution structure of pdp1 pwwp domain reveals its unique binding2 sites for methylated h4k20 and dna Phyre2 PDB 3a8j chain F Region: 6 - 32 Aligned: 26 Modelled: 27 Confidence: 32.3% Identity: 23% PDB header:transferase/transport protein Chain: F: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of et-ehred complex Phyre2 PDB 1onl chain A Region: 6 - 34 Aligned: 28 Modelled: 29 Confidence: 28.2% Identity: 25% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 1 d1ne8a_ 2 c4mzpC_ 3 c5hjzA_ 4 c5hk3B_ 5 d1m1fa_ 6 c5wygC_ 7 d1ub4a_ 8 c5xe3B_ 9 c5ccaA_ 10 c3jrzA_ 11 d3vuba_ 12 d1h3za_ 13 c5ikjA_ 14 c5vc8B_ 15 c3mxuA_ 16 d1ex0a1 17 c2edgA_ 18 c2l89A_ 19 c3a8jF_ 20 d1onla_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99