1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	T	C	E	M	R	E	S	A	L	A	R	L	G	R	A	L	A	D	P	T	R	C	R	I	L	V	A	L	L	D	G	V	C	Y	P	G	Q	L	A	A	H	L	G	L	T	R	S	N	V	S	N	H	L	S	C	L	R	G
Secondary structure
SS confidence
Disorder		?	?	?	?			?																																							?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		C	G	L	V	V	A	T	Y	E	G	R	Q	V	R	Y	A	L	A	D	S	H	L	A	R	A	L	G	E	L	V	Q	V	V	L	A	V	D	T	D	Q	P	C	V	A	E	R	A	A	S	G	E	A	V	E	M	T	G	S
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 54%) Beta strand ( 9%)

Rank Aligned region

PDB 2lkp chain B Region: 4 - 108 Aligned: 105 Modelled: 105 Confidence: 99.9% Identity: 31% PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, arsr family; PDBTitle: solution structure of apo-nmtr Phyre2 PDB 2jsc chain B Region: 10 - 106 Aligned: 97 Modelled: 97 Confidence: 99.9% Identity: 100% PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator rv1994c/mt2050; PDBTitle: nmr structure of the cadmium metal-sensor cmtr from mycobacterium2 tuberculosis Phyre2 PDB 1r22 chain B Region: 1 - 96 Aligned: 95 Modelled: 96 Confidence: 99.9% Identity: 32% PDB header:transcription repressor Chain: B: PDB Molecule:transcriptional repressor smtb; PDBTitle: crystal structure of the cyanobacterial metallothionein2 repressor smtb (c14s/c61s/c121s mutant) in the zn2alpha5-3 form Phyre2 PDB 1r1t chain A Region: 1 - 96 Aligned: 96 Modelled: 96 Confidence: 99.9% Identity: 30% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: ArsR-like transcriptional regulators Phyre2 PDB 1r1u chain A Region: 9 - 93 Aligned: 85 Modelled: 85 Confidence: 99.9% Identity: 31% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: ArsR-like transcriptional regulators Phyre2 PDB 3pqk chain D Region: 9 - 100 Aligned: 92 Modelled: 92 Confidence: 99.9% Identity: 24% PDB header:transcription Chain: D: PDB Molecule:biofilm growth-associated repressor; PDBTitle: crystal structure of the transcriptional repressor bigr from xylella2 fastidiosa Phyre2 PDB 2oqg chain A Region: 9 - 97 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 31% PDB header:transcription Chain: A: PDB Molecule:possible transcriptional regulator, arsr family protein; PDBTitle: arsr-like transcriptional regulator from rhodococcus sp. rha1 Phyre2 PDB 3jth chain A Region: 4 - 94 Aligned: 91 Modelled: 90 Confidence: 99.9% Identity: 30% PDB header:transcription Chain: A: PDB Molecule:transcription activator hlyu; PDBTitle: crystal structure of a transcriptional regulator hlyu from2 vibrio vulnificus cmcp6 Phyre2 PDB 4omz chain G Region: 4 - 94 Aligned: 91 Modelled: 91 Confidence: 99.9% Identity: 29% PDB header:transcription Chain: G: PDB Molecule:nolr; PDBTitle: crystal structure of nolr from sinorhizobium fredii Phyre2 PDB 2kko chain B Region: 9 - 93 Aligned: 85 Modelled: 85 Confidence: 99.9% Identity: 32% PDB header:dna binding protein Chain: B: PDB Molecule:possible transcriptional regulatory protein PDBTitle: solution nmr structure of the homodimeric winged helix-turn-2 helix dna-binding domain (fragment 1-100) mb0332 from3 mycobacterium bovis, a possible arsr-family transcriptional4 regulator. northeast structural genomics consortium target5 mbr242e. Phyre2 PDB 6j05 chain B Region: 7 - 89 Aligned: 83 Modelled: 83 Confidence: 99.9% Identity: 31% PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator arsr; PDBTitle: structures of two arsr as(iii)-responsive repressors: implications for2 the mechanism of derepression Phyre2 PDB 2zkz chain C Region: 9 - 89 Aligned: 80 Modelled: 81 Confidence: 99.9% Identity: 24% PDB header:transcription Chain: C: PDB Molecule:transcriptional repressor pagr; PDBTitle: crystal structure of the transcriptional repressor pagr of bacillus2 anthracis Phyre2 PDB 3cuo chain B Region: 1 - 94 Aligned: 94 Modelled: 94 Confidence: 99.9% Identity: 23% PDB header:transcription regulator Chain: B: PDB Molecule:uncharacterized hth-type transcriptional regulator ygav; PDBTitle: crystal structure of the predicted dna-binding transcriptional2 regulator from e. coli Phyre2 PDB 6j0e chain B Region: 4 - 89 Aligned: 86 Modelled: 86 Confidence: 99.9% Identity: 28% PDB header:transcription Chain: B: PDB Molecule:arsenic responsive repressor arsr; PDBTitle: structures of two arsr as(iii)-responsive repressors: implications for2 the mechanism of derepression Phyre2 PDB 3f6v chain A Region: 11 - 92 Aligned: 82 Modelled: 82 Confidence: 99.9% Identity: 32% PDB header:transcription regulator Chain: A: PDB Molecule:possible transcriptional regulator, arsr family protein; PDBTitle: crystal structure of possible transcriptional regulator for arsenical2 resistance Phyre2 PDB 3f6o chain B Region: 9 - 98 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 22% PDB header:transcription regulator Chain: B: PDB Molecule:probable transcriptional regulator, arsr family PDBTitle: crystal structure of arsr family transcriptional regulator,2 rha00566 Phyre2 PDB 5xpq chain B Region: 9 - 102 Aligned: 89 Modelled: 94 Confidence: 99.9% Identity: 34% PDB header:transcription Chain: B: PDB Molecule:uncharacterized hth-type transcriptional regulator rv0081; PDBTitle: crystal structure of m.tuberculosis rv0081 Phyre2 PDB 1u2w chain A domain 1 Region: 4 - 95 Aligned: 88 Modelled: 92 Confidence: 99.9% Identity: 27% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: ArsR-like transcriptional regulators Phyre2 PDB 2p4w chain A domain 1 Region: 8 - 80 Aligned: 73 Modelled: 73 Confidence: 99.8% Identity: 32% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: PF1790-like Phyre2 PDB 1uly chain A Region: 13 - 80 Aligned: 68 Modelled: 68 Confidence: 99.7% Identity: 25% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Hypothetical protein PH1932 Phyre2 1 c2lkpB_ 2 c2jscB_ 3 c1r22B_ 4 d1r1ta_ 5 d1r1ua_ 6 c3pqkD_ 7 c2oqgA_ 8 c3jthA_ 9 c4omzG_ 10 c2kkoB_ 11 c6j05B_ 12 c2zkzC_ 13 c3cuoB_ 14 c6j0eB_ 15 c3f6vA_ 16 c3f6oB_ 17 c5xpqB_ 18 d1u2wa1 19 d2p4wa1 20 d1ulya_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499