1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	H	H	N	R	D	V	D	L	A	L	V	E	R	P	S	S	G	Y	V	Y	T	T	G	W	R	L	A	T	T	D	I	D	E	H	Q	Q	L	R	L	D	G	V	A	R	Y	I	Q	E	V	G	A	E	H	L	A	D	A	Q	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	E	V	H	P	H	W	I	V	L	R	T	V	I	D	V	I	N	P	I	E	L	P	S	D	I	T	F	H	R	W	C	A	A	L	S	T	R	W	C	S	M	R	V	Q	L	Q	G	S	A	G	G	R	I	E	T	E	G	F	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	C	V	N	K	D	T	L	T	P	S	R	L	T	D	D	C	I	A	R	F	G	S	T	T	E	N	H	R	L	K	W	R	P	W	L	T	G	P	N	I	D	G	T	E	T	P	F	P	L	R	R	T	D	I	D	P	F	E	H
Secondary structure
SS confidence
Disorder								?	?																		?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	N	N	T	I	Y	W	H	G	V	H	E	I	L	C	Q	I	P	T	L	T	A	P	Y	R	A	V	L	E	Y	R	S	P	I	K	S	G	E	P	L	T	I	R	Y	E	Q	H	D	D	V	V	R	M	H	F	V	V	G	D	D
Secondary structure
SS confidence
Disorder																						?														?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250
Sequence		V	R	A	A	A	L	L	R	R	L
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 21%) Beta strand ( 42%)

Rank Aligned region

PDB 2ess chain A Region: 16 - 248 Aligned: 230 Modelled: 233 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:acyl-acp thioesterase; PDBTitle: crystal structure of an acyl-acp thioesterase (np_810988.1) from2 bacteroides thetaiotaomicron vpi-5482 at 1.90 a resolution Phyre2 PDB 5x04 chain B Region: 17 - 248 Aligned: 232 Modelled: 232 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:dodecanoyl-[acyl-carrier-protein] hydrolase, chloroplastic; PDBTitle: 12:0-acp thioesterase from umbellularia californica Phyre2 PDB 4gak chain A Region: 16 - 248 Aligned: 233 Modelled: 231 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:acyl-acp thioesterase; PDBTitle: crystal structure of acyl-acp thioesterase from spirosoma linguale Phyre2 PDB 2own chain A Region: 13 - 248 Aligned: 236 Modelled: 236 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative oleoyl-[acyl-carrier protein] thioesterase; PDBTitle: crystal structure of oleoyl thioesterase (putative) (np_784467.1) from2 lactobacillus plantarum at 2.00 a resolution Phyre2 PDB 2ess chain A domain 1 Region: 16 - 147 Aligned: 132 Modelled: 132 Confidence: 100.0% Identity: 11% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: Acyl-ACP thioesterase-like Phyre2 PDB 2own chain A domain 1 Region: 13 - 153 Aligned: 141 Modelled: 141 Confidence: 100.0% Identity: 11% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: Acyl-ACP thioesterase-like Phyre2 PDB 5byu chain A Region: 17 - 141 Aligned: 125 Modelled: 125 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:thioesterase; PDBTitle: crystal structure of unnamed thioesterase ipg2867 from legionella2 pneumophila Phyre2 PDB 1s5u chain A Region: 19 - 141 Aligned: 123 Modelled: 123 Confidence: 99.9% Identity: 14% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 2oiw chain A domain 1 Region: 21 - 148 Aligned: 128 Modelled: 128 Confidence: 99.9% Identity: 13% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 5v10 chain B Region: 21 - 141 Aligned: 121 Modelled: 121 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the putative tol-pal system-associated acyl-coa2 thioesterase from pseudomonas aeruginosa pao1 Phyre2 PDB 2gf6 chain A domain 1 Region: 16 - 142 Aligned: 127 Modelled: 126 Confidence: 99.9% Identity: 9% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 2ali chain A domain 1 Region: 19 - 141 Aligned: 123 Modelled: 123 Confidence: 99.9% Identity: 15% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 2ali chain A Region: 19 - 141 Aligned: 123 Modelled: 123 Confidence: 99.9% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein pa2801; PDBTitle: structure of protein of unknown function pa2801 from pseudomonas2 aeruginosa, putative thioesterase Phyre2 PDB 2egi chain E Region: 21 - 141 Aligned: 119 Modelled: 119 Confidence: 99.9% Identity: 12% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:hypothetical protein aq_1494; PDBTitle: crystal structure of a hypothetical protein(aq1494) from aquifex2 aeolicus Phyre2 PDB 2o5u chain A domain 1 Region: 13 - 143 Aligned: 131 Modelled: 131 Confidence: 99.9% Identity: 13% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 2oaf chain A domain 1 Region: 13 - 143 Aligned: 131 Modelled: 130 Confidence: 99.9% Identity: 14% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 4k00 chain A Region: 20 - 147 Aligned: 128 Modelled: 128 Confidence: 99.9% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:1,4-dihydroxy-2-naphthoyl-coa hydrolase; PDBTitle: crystal structure of slr0204, a 1,4-dihydroxy-2-naphthoyl-coa2 thioesterase from synechocystis Phyre2 PDB 1njk chain A Region: 21 - 143 Aligned: 123 Modelled: 122 Confidence: 99.9% Identity: 12% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 PDB 5lql chain D Region: 19 - 156 Aligned: 138 Modelled: 138 Confidence: 99.9% Identity: 12% PDB header:hydrolase Chain: D: PDB Molecule:4-hydroxybenzoyl-coa thioesterase; PDBTitle: high resolution crystal structure of the 4-hydroxybenzoyl coenzyme-a2 thioesterase from staphylococcus aureus Phyre2 PDB 2cye chain A domain 1 Region: 16 - 143 Aligned: 125 Modelled: 127 Confidence: 99.9% Identity: 13% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: 4HBT-like Phyre2 1 c2essA_ 2 c5x04B_ 3 c4gakA_ 4 c2ownA_ 5 d2essa1 6 d2owna1 7 c5byuA_ 8 d1s5ua_ 9 d2oiwa1 10 c5v10B_ 11 d2gf6a1 12 d2alia1 13 c2aliA_ 14 c2egiE_ 15 d2o5ua1 16 d2oafa1 17 c4k00A_ 18 d1njka_ 19 c5lqlD_ 20 d2cyea1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146