1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	V	D	T	S	V	W	I	A	Y	L	S	T	S	E	S	L	A	S	R	W	L	A	D	R	I	A	A	D	S	T	V	I	V	P	E	V	V	M	M	E	L	L	I	G	K	T	D	E	D	T	A	A	L	R	R	R	L	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	R	F	A	I	E	P	L	A	P	V	R	D	A	E	D	A	A	A	I	H	R	R	C	R	R	G	G	D	T	V	R	S	L	I	D	C	Q	V	A	A	M	A	L	R	I	G	V	A	V	A	H	R	D	R	D	Y	E	A	I
Secondary structure
SS confidence
Disorder																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.
Sequence		R	T	H	C	G	L	R	T	E	P	L	F
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 61%) Beta strand ( 8%)

Rank Aligned region

PDB 4chg chain C Region: 2 - 132 Aligned: 131 Modelled: 131 Confidence: 100.0% Identity: 98% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 6a7v chain G Region: 1 - 131 Aligned: 131 Modelled: 131 Confidence: 100.0% Identity: 31% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 3h87 chain B Region: 2 - 131 Aligned: 126 Modelled: 130 Confidence: 99.9% Identity: 23% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 5sv2 chain A Region: 1 - 129 Aligned: 125 Modelled: 129 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1v96 chain A domain 1 Region: 1 - 131 Aligned: 124 Modelled: 131 Confidence: 99.9% Identity: 24% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3zvk chain C Region: 1 - 131 Aligned: 127 Modelled: 131 Confidence: 99.9% Identity: 13% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 6nkl chain A Region: 1 - 131 Aligned: 126 Modelled: 131 Confidence: 99.9% Identity: 11% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 3tnd chain C Region: 1 - 131 Aligned: 125 Modelled: 131 Confidence: 99.9% Identity: 19% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5l6m chain C Region: 2 - 131 Aligned: 123 Modelled: 130 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 3dbo chain B Region: 2 - 128 Aligned: 114 Modelled: 127 Confidence: 99.8% Identity: 24% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 131 Aligned: 126 Modelled: 131 Confidence: 99.8% Identity: 21% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1y82 chain A domain 1 Region: 1 - 130 Aligned: 123 Modelled: 128 Confidence: 99.8% Identity: 24% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4xgr chain G Region: 2 - 119 Aligned: 116 Modelled: 118 Confidence: 99.8% Identity: 18% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 5wzf chain B Region: 1 - 130 Aligned: 126 Modelled: 130 Confidence: 99.8% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 5x3t chain D Region: 2 - 130 Aligned: 129 Modelled: 129 Confidence: 99.8% Identity: 19% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 2fe1 chain A Region: 1 - 126 Aligned: 121 Modelled: 126 Confidence: 99.5% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 2fe1 chain A domain 1 Region: 1 - 126 Aligned: 121 Modelled: 126 Confidence: 99.5% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3i8o chain A Region: 1 - 131 Aligned: 125 Modelled: 131 Confidence: 99.2% Identity: 18% PDB header:rna binding protein Chain: A: PDB Molecule:kh domain-containing protein mj1533; PDBTitle: a domain of a functionally unknown protein from methanocaldococcus2 jannaschii dsm 2661. Phyre2 PDB 3ix7 chain A Region: 1 - 128 Aligned: 105 Modelled: 112 Confidence: 98.9% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 1w8i chain A Region: 1 - 117 Aligned: 117 Modelled: 117 Confidence: 98.8% Identity: 13% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c4chgC_ 2 c6a7vG_ 3 c3h87B_ 4 c5sv2A_ 5 d1v96a1 6 c3zvkC_ 7 c6nklA_ 8 c3tndC_ 9 c5l6mC_ 10 c3dboB_ 11 d2h1ca1 12 d1y82a1 13 c4xgrG_ 14 c5wzfB_ 15 c5x3tD_ 16 c2fe1A_ 17 d2fe1a1 18 c3i8oA_ 19 c3ix7A_ 20 d1w8ia_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49