1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	P	G	M	K	W	A	A	K	T	D	H	L	A	I	V	L	L	P	R	H	H	R	R	H	S	R	R	G	R	A	L	P	A	R	S	R	S	A	L	G	W	I	I	E	R	Y	R	V	T	T	D	K	A	S	G	I	V	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?																				?	?	?	?	?														?	?		?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.
Sequence		D	P	N	D	W	C	D	E	H	D	D	P	T	Y	I	V	D	L	I	K	K	V	T	T	V	S	V	E	T	M	K	I	V	D	G	L	A	G	G
Secondary structure
SS confidence
Disorder											?																									?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 51%) Beta strand ( 5%)

Rank Aligned region

PDB 4xqk chain B Region: 4 - 97 Aligned: 87 Modelled: 94 Confidence: 100.0% Identity: 39% PDB header:hydrolase/dna Chain: B: PDB Molecule:llabiii; PDBTitle: atp-dependent type isp restriction-modification enzyme llabiii bound2 to dna Phyre2 PDB 3pgv chain B Region: 11 - 68 Aligned: 54 Modelled: 56 Confidence: 53.2% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:haloacid dehalogenase-like hydrolase; PDBTitle: crystal structure of a haloacid dehalogenase-like hydrolase2 (kpn_04322) from klebsiella pneumoniae subsp. pneumoniae mgh 78578 at3 2.39 a resolution Phyre2 PDB 3dnp chain A Region: 7 - 68 Aligned: 58 Modelled: 60 Confidence: 51.7% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:stress response protein yhax; PDBTitle: crystal structure of stress response protein yhax from bacillus2 subtilis Phyre2 PDB 4bnd chain B Region: 12 - 85 Aligned: 70 Modelled: 74 Confidence: 45.3% Identity: 13% PDB header:isomerase Chain: B: PDB Molecule:alpha-phosphoglucomutase; PDBTitle: structure of an atypical alpha-phosphoglucomutase similar to2 eukaryotic phosphomannomutases Phyre2 PDB 1nrw chain A Region: 9 - 68 Aligned: 56 Modelled: 60 Confidence: 37.6% Identity: 14% Fold: HAD-like Superfamily: HAD-like Family: Predicted hydrolases Cof Phyre2 PDB 1nf2 chain A Region: 11 - 68 Aligned: 54 Modelled: 58 Confidence: 37.4% Identity: 13% Fold: HAD-like Superfamily: HAD-like Family: Predicted hydrolases Cof Phyre2 PDB 3niw chain A Region: 11 - 68 Aligned: 54 Modelled: 56 Confidence: 34.3% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:haloacid dehalogenase-like hydrolase; PDBTitle: crystal structure of a haloacid dehalogenase-like hydrolase from2 bacteroides thetaiotaomicron Phyre2 PDB 3fzq chain A Region: 9 - 68 Aligned: 56 Modelled: 58 Confidence: 31.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative hydrolase; PDBTitle: crystal structure of putative haloacid dehalogenase-like hydrolase2 (yp_001086940.1) from clostridium difficile 630 at 2.10 a resolution Phyre2 PDB 3gyg chain A Region: 24 - 68 Aligned: 45 Modelled: 43 Confidence: 30.5% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:ntd biosynthesis operon putative hydrolase ntdb; PDBTitle: crystal structure of yhjk (haloacid dehalogenase-like hydrolase2 protein) from bacillus subtilis Phyre2 PDB 1s2o chain A domain 1 Region: 7 - 68 Aligned: 58 Modelled: 62 Confidence: 29.3% Identity: 5% Fold: HAD-like Superfamily: HAD-like Family: Predicted hydrolases Cof Phyre2 PDB 2rbk chain A domain 1 Region: 31 - 68 Aligned: 38 Modelled: 38 Confidence: 28.6% Identity: 13% Fold: HAD-like Superfamily: HAD-like Family: Predicted hydrolases Cof Phyre2 PDB 3ebn chain D Region: 54 - 90 Aligned: 37 Modelled: 37 Confidence: 24.5% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:replicase polyprotein 1ab; PDBTitle: a special dimerization of sars-cov main protease c-terminal2 domain due to domain-swapping Phyre2 PDB 3d23 chain A Region: 54 - 90 Aligned: 37 Modelled: 37 Confidence: 23.9% Identity: 24% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:3c-like proteinase; PDBTitle: main protease of hcov-hku1 Phyre2 PDB 6cj0 chain A Region: 31 - 68 Aligned: 38 Modelled: 37 Confidence: 23.9% Identity: 11% PDB header:lyase Chain: A: PDB Molecule:trehalose phosphatase; PDBTitle: chromosomal trehalose-6-phosphate phosphatase from p. aeruginosa Phyre2 PDB 3tqd chain A Region: 30 - 49 Aligned: 20 Modelled: 20 Confidence: 22.0% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:3-deoxy-manno-octulosonate cytidylyltransferase; PDBTitle: structure of the 3-deoxy-d-manno-octulosonate cytidylyltransferase2 (kdsb) from coxiella burnetii Phyre2 PDB 1xvi chain A Region: 31 - 68 Aligned: 38 Modelled: 38 Confidence: 21.9% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:putative mannosyl-3-phosphoglycerate phosphatase; PDBTitle: crystal structure of yedp, phosphatase-like domain protein2 from escherichia coli k12 Phyre2 PDB 1xvi chain A Region: 31 - 68 Aligned: 38 Modelled: 38 Confidence: 21.9% Identity: 26% Fold: HAD-like Superfamily: HAD-like Family: Predicted hydrolases Cof Phyre2 PDB 2duc chain A domain 1 Region: 54 - 90 Aligned: 37 Modelled: 37 Confidence: 21.5% Identity: 19% Fold: Trypsin-like serine proteases Superfamily: Trypsin-like serine proteases Family: Viral cysteine protease of trypsin fold Phyre2 PDB 2qyh chain D Region: 12 - 68 Aligned: 53 Modelled: 55 Confidence: 21.4% Identity: 13% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical conserved protein, gk1056; PDBTitle: crystal structure of the hypothetical protein (gk1056) from2 geobacillus kaustophilus hta426 Phyre2 PDB 3nbm chain A Region: 1 - 49 Aligned: 44 Modelled: 49 Confidence: 20.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:pts system, lactose-specific iibc components; PDBTitle: the lactose-specific iib component domain structure of the2 phosphoenolpyruvate:carbohydrate phosphotransferase system (pts) from3 streptococcus pneumoniae. Phyre2 1 c4xqkB_ 2 c3pgvB_ 3 c3dnpA_ 4 c4bndB_ 5 d1nrwa_ 6 d1nf2a_ 7 c3niwA_ 8 c3fzqA_ 9 c3gygA_ 10 d1s2oa1 11 d2rbka1 12 c3ebnD_ 13 c3d23A_ 14 c6cj0A_ 15 c3tqdA_ 16 c1xviA_ 17 d1xvia_ 18 d2duca1 19 c2qyhD_ 20 c3nbmA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99