1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	A	R	H	A	R	A	G	R	W	A	A	Q	P	R	P	M	L	G	S	G	A	V	R	Y	E	V	G	A	N	I	D	A	T	G	F	G	G	I	A	A	V	H	R	L	V	T	R	L	G	L	V	T	R	L	G	L	V	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?							?																														?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.
Sequence		R	V	D	A	H	S	R	F	S	S	S	N	L	P	K	S	S	R	R	I	S	G	R	V	S	L	S	G	M	S	N	S	A	A	K	V	V	A	S	T	S	S	S	P	W	G	Q	P	L	S	V	G	L	R	R	R	W	R	S
Secondary structure
SS confidence
Disorder					?			?	?	?	?	?	?		?	?				?	?	?	?				?	?		?		?	?	?						?	?	?	?		?	?								?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 41%) Alpha helix ( 40%) Beta strand ( 21%)

Rank Aligned region

PDB 5e9f chain D Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 18.1% Identity: 44% PDB header:lyase Chain: D: PDB Molecule:isocitrate lyase; PDBTitle: structural insights of isocitrate lyases from magnaporthe oryzae Phyre2 PDB 2r7m chain A Region: 93 - 114 Aligned: 22 Modelled: 22 Confidence: 14.9% Identity: 50% PDB header:ligase Chain: A: PDB Molecule:5-formaminoimidazole-4-carboxamide-1-(beta)-d-ribofuranosyl PDBTitle: crystal structure of faicar synthetase (purp) from m. jannaschii2 complexed with amp Phyre2 PDB 5d5o chain E Region: 32 - 40 Aligned: 9 Modelled: 9 Confidence: 13.4% Identity: 67% PDB header:unknown function Chain: E: PDB Molecule:uncharacterized protein mj0489; PDBTitle: hcgc from methanocaldococcus jannaschii Phyre2 PDB 1dqu chain A Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 13.0% Identity: 44% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Phosphoenolpyruvate mutase/Isocitrate lyase-like Phyre2 PDB 3bne chain A domain 2 Region: 10 - 43 Aligned: 33 Modelled: 34 Confidence: 12.2% Identity: 21% Fold: Lipase/lipooxygenase domain (PLAT/LH2 domain) Superfamily: Lipase/lipooxygenase domain (PLAT/LH2 domain) Family: Lipoxigenase N-terminal domain Phyre2 PDB 1f61 chain A Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 11.9% Identity: 44% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Phosphoenolpyruvate mutase/Isocitrate lyase-like Phyre2 PDB 1igw chain A Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 11.6% Identity: 31% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Phosphoenolpyruvate mutase/Isocitrate lyase-like Phyre2 PDB 3j81 chain J Region: 64 - 84 Aligned: 21 Modelled: 21 Confidence: 11.5% Identity: 24% PDB header:ribosome Chain: J: PDB Molecule:us4; PDBTitle: cryoem structure of a partial yeast 48s preinitiation complex Phyre2 PDB 5o4j chain C Region: 32 - 40 Aligned: 9 Modelled: 9 Confidence: 10.5% Identity: 67% PDB header:transferase Chain: C: PDB Molecule:hcgc; PDBTitle: hcgc from methanococcus maripaludis cocrystallized with sah and2 pyridinol Phyre2 PDB 2j01 chain D domain 1 Region: 101 - 116 Aligned: 15 Modelled: 16 Confidence: 9.3% Identity: 47% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: C-terminal domain of ribosomal protein L2 Phyre2 PDB 2qam chain C domain 1 Region: 101 - 116 Aligned: 15 Modelled: 16 Confidence: 8.8% Identity: 33% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: C-terminal domain of ribosomal protein L2 Phyre2 PDB 2gya chain A Region: 101 - 108 Aligned: 8 Modelled: 8 Confidence: 7.9% Identity: 38% PDB header:ribosome Chain: A: PDB Molecule:50s ribosomal protein l2; PDBTitle: structure of the 50s subunit of a pre-translocational e. coli ribosome2 obtained by fitting atomic models for rna and protein components into3 cryo-em map emd-1056 Phyre2 PDB 2zjr chain A domain 1 Region: 101 - 108 Aligned: 8 Modelled: 8 Confidence: 7.8% Identity: 50% Fold: SH3-like barrel Superfamily: Translation proteins SH3-like domain Family: C-terminal domain of ribosomal protein L2 Phyre2 PDB 1q46 chain A Region: 64 - 85 Aligned: 22 Modelled: 22 Confidence: 7.2% Identity: 23% PDB header:translation Chain: A: PDB Molecule:translation initiation factor 2 alpha subunit; PDBTitle: crystal structure of the eif2 alpha subunit from2 saccharomyces cerevisia Phyre2 PDB 3e5b chain B Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 6.8% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:isocitrate lyase; PDBTitle: 2.4 a crystal structure of isocitrate lyase from brucella melitensis Phyre2 PDB 3i4e chain A Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 6.4% Identity: 31% PDB header:lyase Chain: A: PDB Molecule:isocitrate lyase; PDBTitle: crystal structure of isocitrate lyase from burkholderia2 pseudomallei Phyre2 PDB 1inz chain A Region: 70 - 108 Aligned: 39 Modelled: 39 Confidence: 6.3% Identity: 33% Fold: alpha-alpha superhelix Superfamily: ENTH/VHS domain Family: ENTH domain Phyre2 PDB 3d5b chain D Region: 101 - 116 Aligned: 15 Modelled: 16 Confidence: 6.3% Identity: 47% PDB header:ribosome Chain: D: PDB Molecule:50s ribosomal protein l2; PDBTitle: structural basis for translation termination on the 70s ribosome. this2 file contains the 50s subunit of one 70s ribosome. the entire crystal3 structure contains two 70s ribosomes as described in remark 400. Phyre2 PDB 2z4l chain C Region: 101 - 108 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 38% PDB header:ribosome Chain: C: PDB Molecule:50s ribosomal protein l2; PDBTitle: crystal structure of the bacterial ribosome from escherichia coli in2 complex with paromomycin and ribosome recycling factor (rrf). this3 file contains the 50s subunit of the first 70s ribosome, with4 paromomycin and rrf bound. the entire crystal structure contains two5 70s ribosomes and is described in remark 400. Phyre2 PDB 4owf chain G Region: 9 - 14 Aligned: 6 Modelled: 6 Confidence: 5.8% Identity: 83% PDB header:transcription/protein binding Chain: G: PDB Molecule:e3 ubiquitin-protein ligase rnf31; PDBTitle: crystal structure of the nemo cozi in complex with hoip nzf1 domain Phyre2 1 c5e9fD_ 2 c2r7mA_ 3 c5d5oE_ 4 d1dqua_ 5 d3bnea2 6 d1f61a_ 7 d1igwa_ 8 c3j81j_ 9 c5o4jC_ 10 d2j01d1 11 d2qamc1 12 c2gyaA_ 13 d2zjra1 14 c1q46A_ 15 c3e5bB_ 16 c3i4eA_ 17 d1inza_ 18 c3d5bD_ 19 c2z4lC_ 20 c4owfG_ 21