1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	A	T	A	K	Y	G	I	L	V	G	V	D	G	S	A	Q	S	N	A	A	V	A	W	A	A	R	E	A	V	M	R	Q	L	P	I	T	L	L	H	I	V	A	P	V	V	V	G	W	P	V	G	Q	L	Y	A	N	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																											?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	E	W	Q	K	D	N	A	Q	Q	V	I	E	Q	A	R	E	A	L	T	N	S	L	G	E	S	K	P	P	Q	V	H	T	E	L	V	F	S	N	V	V	P	T	L	I	D	A	S	Q	Q	A	W	L	M	V	V	G	S	Q	G
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	G	A	L	G	R	L	L	L	G	S	I	S	T	A	L	L	H	H	A	R	C	P	V	A	I	I	H	S	G	N	G	A	T	P	D	S	D	A	P	V	L	V	G	I	D	G	S	P	A	S	E	A	A	T	A	L	A	F	D
Secondary structure
SS confidence
Disorder																																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	A	S	R	R	R	V	D	L	V	A	L	H	A	W	T	D	L	G	M	F	P	V	L	G	M	D	W	R	E	R	E	K	R	E	A	E	V	L	A	E	R	L	A	G	W	Q	E	Q	Y	P	D	V	R	V	H	R	S	L	V
Secondary structure
SS confidence
Disorder																				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.
Sequence		C	D	K	P	A	R	W	L	L	E	H	S	E	Q	A	Q	L	V	V	V	G	S	H	G	R	G	G	F	S	G	M	L	L	G	S	V	S	S	A	V	A	H	S	V	R	I	P	V	I	V	V	R	P	S
Secondary structure
SS confidence
Disorder																																																						?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 41%) Beta strand ( 21%)

Rank Aligned region

PDB 2jax chain A Region: 8 - 292 Aligned: 260 Modelled: 269 Confidence: 100.0% Identity: 55% PDB header:protein binding Chain: A: PDB Molecule:hypothetical protein tb31.7; PDBTitle: universal stress protein rv2623 from mycobaterium2 tuberculosis Phyre2 PDB 3olq chain A Region: 6 - 293 Aligned: 287 Modelled: 288 Confidence: 100.0% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:universal stress protein e; PDBTitle: the crystal structure of a universal stress protein e from proteus2 mirabilis hi4320 Phyre2 PDB 3loq chain A Region: 9 - 294 Aligned: 261 Modelled: 267 Confidence: 100.0% Identity: 21% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:universal stress protein; PDBTitle: the crystal structure of a universal stress protein from archaeoglobus2 fulgidus dsm 4304 Phyre2 PDB 3mt0 chain A Region: 8 - 293 Aligned: 252 Modelled: 263 Confidence: 100.0% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein pa1789; PDBTitle: the crystal structure of a functionally unknown protein pa1789 from2 pseudomonas aeruginosa pao1 Phyre2 PDB 3ab8 chain B Region: 9 - 292 Aligned: 259 Modelled: 265 Confidence: 100.0% Identity: 20% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein ttha0350; PDBTitle: crystal structure of the hypothetical tandem-type universal stress2 protein ttha0350 complexed with atps. Phyre2 PDB 4r2j chain A Region: 8 - 293 Aligned: 276 Modelled: 286 Confidence: 100.0% Identity: 12% PDB header:metal binding protein, unknown function Chain: A: PDB Molecule:universal stress protein e; PDBTitle: crystal structure of ydaa (universal stress protein e) from salmonella2 typhimurium Phyre2 PDB 3s3t chain D Region: 8 - 292 Aligned: 138 Modelled: 138 Confidence: 99.9% Identity: 35% PDB header:chaperone Chain: D: PDB Molecule:nucleotide-binding protein, universal stress protein uspa PDBTitle: universal stress protein uspa from lactobacillus plantarum Phyre2 PDB 3hgm chain D Region: 8 - 291 Aligned: 137 Modelled: 139 Confidence: 99.9% Identity: 37% PDB header:signaling protein Chain: D: PDB Molecule:universal stress protein tead; PDBTitle: universal stress protein tead from the trap transporter teaabc of2 halomonas elongata Phyre2 PDB 1tq8 chain A Region: 1 - 294 Aligned: 124 Modelled: 124 Confidence: 99.8% Identity: 34% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 PDB 3fh0 chain A Region: 7 - 292 Aligned: 122 Modelled: 124 Confidence: 99.8% Identity: 41% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative universal stress protein kpn_01444; PDBTitle: crystal structure of putative universal stress protein kpn_01444 -2 atpase Phyre2 PDB 3dlo chain C Region: 158 - 292 Aligned: 129 Modelled: 127 Confidence: 99.8% Identity: 22% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:universal stress protein; PDBTitle: structure of universal stress protein from archaeoglobus fulgidus Phyre2 PDB 2z3v chain A domain 1 Region: 158 - 291 Aligned: 133 Modelled: 134 Confidence: 99.8% Identity: 25% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 PDB 4wny chain A Region: 8 - 293 Aligned: 125 Modelled: 136 Confidence: 99.8% Identity: 26% PDB header:signaling protein Chain: A: PDB Molecule:universal stress protein; PDBTitle: crystal structure of a protein from the universal stress protein2 family from burkholderia pseudomallei Phyre2 PDB 5ahw chain C Region: 156 - 294 Aligned: 139 Modelled: 139 Confidence: 99.8% Identity: 24% PDB header:signaling protein Chain: C: PDB Molecule:universal stress protein; PDBTitle: crystal structure of universal stress protein msmeg_3811 in2 complex with camp Phyre2 PDB 1mjh chain A Region: 158 - 293 Aligned: 136 Modelled: 136 Confidence: 99.7% Identity: 19% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 PDB 4r2l chain B Region: 159 - 292 Aligned: 131 Modelled: 134 Confidence: 99.7% Identity: 24% PDB header:unknown function Chain: B: PDB Molecule:universal stress protein f; PDBTitle: crystal structure of ynaf (universal stress protein f) from salmonella2 typhimurium Phyre2 PDB 2gm3 chain A domain 1 Region: 158 - 293 Aligned: 128 Modelled: 136 Confidence: 99.7% Identity: 20% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 PDB 3fg9 chain B Region: 154 - 292 Aligned: 132 Modelled: 139 Confidence: 99.7% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein of universal stress protein uspa family; PDBTitle: the crystal structure of an universal stress protein uspa2 family protein from lactobacillus plantarum wcfs1 Phyre2 PDB 1q77 chain A Region: 4 - 139 Aligned: 136 Modelled: 136 Confidence: 99.6% Identity: 15% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 PDB 1jmv chain A Region: 158 - 292 Aligned: 132 Modelled: 135 Confidence: 99.6% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: Universal stress protein-like Phyre2 1 c2jaxA_ 2 c3olqA_ 3 c3loqA_ 4 c3mt0A_ 5 c3ab8B_ 6 c4r2jA_ 7 c3s3tD_ 8 c3hgmD_ 9 d1tq8a_ 10 c3fh0A_ 11 c3dloC_ 12 d2z3va1 13 c4wnyA_ 14 c5ahwC_ 15 d1mjha_ 16 c4r2lB_ 17 d2gm3a1 18 c3fg9B_ 19 d1q77a_ 20 d1jmva_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99