1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	W	A	D	R	I	V	H	R	H	F	I	R	G	L	A	L	Y	A	G	L	I	G	I	A	W	C	A	L	F	P	I	I	W	A	L	S	G	S	L	K	A	D	G	E	V	T	E	P	T	L	F	P	S	H	P	Q	W	S
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?	?	?	?																																	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	Y	R	E	V	F	A	L	M	P	F	W	R	M	F	F	N	T	V	L	Y	A	G	C	V	T	A	G	Q	V	F	F	C	S	L	A	G	Y	A	F	A	R	L	Q	F	R	G	R	D	T	L	F	V	L	Y	L	S	T	L	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	P	L	T	V	T	V	I	P	Q	V	I	L	M	R	I	V	G	W	V	D	T	P	W	A	M	I	V	P	G	L	F	G	S	A	F	G	T	Y	L	M	R	Q	F	F	R	T	L	P	T	D	L	E	E	A	A	I	L	D	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	S	P	W	Q	I	Y	W	R	I	L	L	P	H	S	R	P	A	V	L	V	L	G	V	L	T	W	V	N	V	W	N	D	F	L	W	P	L	L	M	I	Q	R	N	S	L	A	T	L	T	L	G	L	V	R	L	R	G	E	Y
Secondary structure
SS confidence
Disorder																																														?	?										?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence		V	A	R	W	P	V	L	M	A	A	S	M	L	M	L	V	P	L	V	I	L	Y	A	V	A	Q	R	S	F	V	R	G	I	A	V	T	G	L	G	G
Secondary structure
SS confidence
Disorder		?																																		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 2r6g chain G domain 1 Region: 9 - 280 Aligned: 271 Modelled: 272 Confidence: 100.0% Identity: 27% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 4tqv chain J Region: 4 - 273 Aligned: 267 Modelled: 270 Confidence: 100.0% Identity: 25% PDB header:transport protein Chain: J: PDB Molecule:algm2; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 3fh6 chain F Region: 5 - 267 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 4tqv chain I Region: 3 - 271 Aligned: 257 Modelled: 268 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: I: PDB Molecule:algm1; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 2r6g chain F Region: 43 - 264 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 22% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2onk chain C domain 1 Region: 11 - 267 Aligned: 238 Modelled: 242 Confidence: 100.0% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 11 - 267 Aligned: 238 Modelled: 242 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 3d31 chain D Region: 16 - 266 Aligned: 233 Modelled: 237 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease protein; PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3d31 chain C domain 1 Region: 16 - 266 Aligned: 233 Modelled: 237 Confidence: 100.0% Identity: 15% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F domain 2 Region: 59 - 264 Aligned: 206 Modelled: 206 Confidence: 100.0% Identity: 22% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 4ymu chain C Region: 58 - 271 Aligned: 210 Modelled: 214 Confidence: 100.0% Identity: 9% PDB header:protein binding/transport protein Chain: C: PDB Molecule:abc-type amino acid transport system, permease component; PDBTitle: crystal structure of an amino acid abc transporter complex with2 arginines and atps Phyre2 PDB 3dhw chain A domain 1 Region: 71 - 264 Aligned: 189 Modelled: 194 Confidence: 99.8% Identity: 13% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F domain 1 Region: 9 - 51 Aligned: 43 Modelled: 43 Confidence: 84.0% Identity: 19% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 5kbu chain A Region: 113 - 256 Aligned: 139 Modelled: 144 Confidence: 57.5% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:glutamate receptor 2,voltage-dependent calcium channel PDBTitle: cryo-em structure of glua2-2xstz complex at 7.8 angstrom resolution Phyre2 PDB 2hx6 chain A Region: 159 - 184 Aligned: 26 Modelled: 26 Confidence: 28.7% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease; PDBTitle: solution structure analysis of the phage t42 endoribonuclease regb Phyre2 PDB 3hd7 chain A Region: 4 - 35 Aligned: 32 Modelled: 32 Confidence: 19.5% Identity: 22% PDB header:exocytosis Chain: A: PDB Molecule:vesicle-associated membrane protein 2; PDBTitle: helical extension of the neuronal snare complex into the membrane,2 spacegroup c 1 2 1 Phyre2 PDB 2m8g chain X Region: 160 - 183 Aligned: 24 Modelled: 24 Confidence: 18.3% Identity: 17% PDB header:transcription Chain: X: PDB Molecule:transcriptional regulator; PDBTitle: structure, function, and tethering of dna-binding domains in 542 transcriptional activators Phyre2 PDB 4l5e chain A Region: 160 - 190 Aligned: 31 Modelled: 31 Confidence: 18.0% Identity: 13% PDB header:protein binding Chain: A: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of a. aeolicus ntrc1 dna binding domain Phyre2 PDB 1umq chain A Region: 160 - 190 Aligned: 31 Modelled: 31 Confidence: 15.3% Identity: 6% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1umq chain A Region: 160 - 190 Aligned: 31 Modelled: 31 Confidence: 15.3% Identity: 6% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 1 d2r6gg1 2 c4tqvJ_ 3 c3fh6F_ 4 c4tqvI_ 5 c2r6gF_ 6 d2onkc1 7 c2onkC_ 8 c3d31D_ 9 d3d31c1 10 d2r6gf2 11 c4ymuC_ 12 d3dhwa1 13 d2r6gf1 14 c5kbuA_ 15 c2hx6A_ 16 c3hd7A_ 17 c2m8gX_ 18 c4l5eA_ 19 d1umqa_ 20 c1umqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39