1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	Q	I	P	V	K	L	L	V	N	G	R	V	Y	S	P	T	H	P	E	A	T	A	M	A	V	R	G	D	V	V	A	W	L	G	S	D	D	V	G	R	D	Q	F	P	D	A	D	V	Q	D	L	D	G	R	F	V	A	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	F	V	D	S	H	I	H	L	T	A	T	G	L	M	L	S	G	L	D	L	R	P	A	T	S	R	A	Q	C	L	R	M	V	A	D	Y	A	A	D	H	P	G	Q	P	L	W	G	H	G	W	D	E	S	A	W	P	E	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	P	S	T	A	D	L	D	A	V	L	G	D	C	P	A	Y	L	A	R	I	D	S	H	S	A	L	V	S	S	G	L	R	R	L	V	P	E	L	A	A	A	T	G	Y	T	A	Q	R	P	L	T	G	D	A	H	H	L	A	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	A	R	Y	L	L	T	D	V	Q	L	A	D	A	R	A	V	A	L	Q	A	I	A	A	A	G	V	V	A	V	H	E	C	A	G	P	E	I	G	G	L	D	D	W	L	R	L	R	A	L	E	H	G	V	E	V	I	G	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	G	E	A	V	A	T	P	A	Q	A	R	D	L	V	T	E	T	G	A	R	G	L	A	G	D	L	F	V	D	G	A	L	G	S	R	T	A	W	L	H	E	P	Y	A	D	A	P	D	C	I	G	T	C	H	L	D	V	D	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	E	A	H	V	R	A	C	T	K	A	E	V	T	A	G	F	H	V	I	G	D	A	A	V	S	A	A	V	A	A	F	E	R	V	V	A	D	L	G	V	V	A	V	A	R	C	G	H	R	L	E	H	V	E	M	V	T	A	D
Secondary structure
SS confidence
Disorder																																										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Q	A	A	K	L	G	A	W	G	V	I	A	S	V	Q	P	N	F	D	E	L	W	G	G	G	D	G	M	Y	A	R	R	L	G	A	Q	R	G	S	E	L	N	P	L	A	L	L	A	S	Q	G	V	P	L	A	L	G	S	D	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	V	T	G	F	D	P	W	A	S	V	R	A	A	V	N	H	R	T	P	G	S	G	V	S	A	R	A	A	F	A	A	A	T	R	G	G	W	R	A	G	G	V	R	D	G	R	I	G	T	L	V	P	G	A	P	A	S	Y	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.
Sequence		I	W	D	A	G	D	F	D	V	D	A	P	R	D	A	V	Q	R	W	S	T	D	P	R	S	R	V	P	A	L	P	R	L	G	P	T	D	A	L	P	R	C	R	Q	T	V	H	R	G	A	V	I	Y	G
Secondary structure
SS confidence
Disorder																																	?	?	?	?														?			?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 38%) Beta strand ( 20%)

Rank Aligned region

PDB 3igh chain X Region: 6 - 493 Aligned: 463 Modelled: 488 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: X: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent hydrolase from2 pyrococcus horikoshii ot3 Phyre2 PDB 3etk chain A Region: 6 - 488 Aligned: 458 Modelled: 476 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from pyrococcus furiosus Phyre2 PDB 6oha chain A Region: 7 - 533 Aligned: 416 Modelled: 424 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:probable guanine deaminase; PDBTitle: yeast guanine deaminase Phyre2 PDB 4dzh chain A Region: 3 - 533 Aligned: 398 Modelled: 399 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from xanthomonas2 campestris (target nysgrc-200456) with bound zn Phyre2 PDB 4dyk chain B Region: 6 - 533 Aligned: 392 Modelled: 394 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from pseudomonas2 aeruginosa pao1 (target nysgrc-200449) with bound zn Phyre2 PDB 4v1x chain A Region: 6 - 533 Aligned: 407 Modelled: 411 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:atrazine chlorohydrolase; PDBTitle: the structure of the hexameric atrazine chlorohydrolase, atza Phyre2 PDB 2i9u chain A Region: 6 - 533 Aligned: 399 Modelled: 413 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cytosine/guanine deaminase related protein; PDBTitle: crystal structure of guanine deaminase from c. acetobutylicum with2 bound guanine in the active site Phyre2 PDB 3lnp chain A Region: 6 - 533 Aligned: 398 Modelled: 411 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase family protein olei01672_1_465; PDBTitle: crystal structure of amidohydrolase family protein olei01672_1_4652 from oleispira antarctica Phyre2 PDB 3lsb chain A Region: 6 - 533 Aligned: 412 Modelled: 417 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:triazine hydrolase; PDBTitle: crystal structure of the mutant e241q of atrazine chlorohydrolase trzn2 from arthrobacter aurescens tc1 complexed with zinc and ametrin Phyre2 PDB 2paj chain A Region: 5 - 533 Aligned: 380 Modelled: 387 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:putative cytosine/guanine deaminase; PDBTitle: crystal structure of an amidohydrolase from an environmental sample of2 sargasso sea Phyre2 PDB 4c65 chain A Region: 2 - 534 Aligned: 414 Modelled: 430 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:ochratoxinase; PDBTitle: crystal structure of a. niger ochratoxinase Phyre2 PDB 4f0r chain A Region: 6 - 533 Aligned: 394 Modelled: 394 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:5-methylthioadenosine/s-adenosylhomocysteine deaminase; PDBTitle: crystal structure of an adenosine deaminase homolog from2 chromobacterium violaceum (target nysgrc-019589) bound zn and 5'-3 methylthioadenosine (unproductive complex) Phyre2 PDB 2bb0 chain A Region: 3 - 533 Aligned: 390 Modelled: 393 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: structure of imidazolonepropionase from bacillus subtilis Phyre2 PDB 4wgx chain D Region: 4 - 533 Aligned: 421 Modelled: 429 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:molinate hydrolase; PDBTitle: crystal structure of molinate hydrolase Phyre2 PDB 2gok chain A Region: 6 - 532 Aligned: 389 Modelled: 399 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of the imidazolonepropionase from agrobacterium2 tumefaciens at 1.87 a resolution Phyre2 PDB 3hpa chain B Region: 6 - 533 Aligned: 387 Modelled: 396 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an amidohydrolase gi:44264246 from an2 evironmental sample of sargasso sea Phyre2 PDB 1p1m chain A Region: 7 - 533 Aligned: 373 Modelled: 390 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein tm0936; PDBTitle: structure of thermotoga maritima amidohydrolase tm09362 bound to ni and methionine Phyre2 PDB 3e0l chain B Region: 5 - 534 Aligned: 415 Modelled: 427 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:guanine deaminase; PDBTitle: computationally designed ammelide deaminase Phyre2 PDB 3dc8 chain B Region: 6 - 533 Aligned: 381 Modelled: 398 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from sinorhizobium meliloti Phyre2 PDB 5e5c chain C Region: 6 - 533 Aligned: 407 Modelled: 418 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:d-hydantoinase/dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from pseudomonas aeruginosa2 pao1 Phyre2 1 c3ighX_ 2 c3etkA_ 3 c6ohaA_ 4 c4dzhA_ 5 c4dykB_ 6 c4v1xA_ 7 c2i9uA_ 8 c3lnpA_ 9 c3lsbA_ 10 c2pajA_ 11 c4c65A_ 12 c4f0rA_ 13 c2bb0A_ 14 c4wgxD_ 15 c2gokA_ 16 c3hpaB_ 17 c1p1mA_ 18 c3e0lB_ 19 c3dc8B_ 20 c5e5cC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221